GSE112366

Intestinal epithelial microvilli are abnormal in Crohn's disease

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

362 case / 26 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source
GEO
Assay
microarray
Organism
Homo sapiens
Whole-study samples
388 samples
Specimen
Biopsy
Reported/interpreted study design
Treatment vs control Design classification does not establish patient pairs.
Comparison type
Tumor vs normal
Contributors
VanDussen KL, Stojmirović A, Li K, Liu T, Kimes PK, Muegge BD, Simpson KF, Ciorba MA, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS
Contact name
K Li
Submission date
2018-03-27
Last update
2019-03-20
Organization
Janssen R&D
Department
Not available
Public date
2019-03-20
Experiment types
Expression profiling by array
Platforms
GPL13158 [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate
Series type
Series
SubSeries
Not available
BioProject
PRJNA445829

Summary

Biopsy samples (n=362) were collected from terminal ileum at baseline, 8 weeks after induction (Ustekinumab or placebo), and 44 weeks after maintenance (Ustekinumab 90 mg SC q12w, Ustekinumab 90 mg SC q8w, or placebo) therapies during endoscopy for RNA extraction and microarray analysis from patients with moderate-to-severe CD who participated in stelara CD phase 3 studies (UNITI-2 and IM-UNITI). These patients failed conventional therapies previously and largely naive to anti-TNF therpy. Ileum biopsies (n=26) collected from non-IBD subjects were also analyzed to serve as control. Enrichment of a core microvilli gene set was found to be reduced in UNITI-2 CD samples relative to controls, correlated with microvilli length and endoscopy score, and associated with response to treatment.

Overall design

A gene expression profiling study was conducted in which ileum biopsy samples were collected for RNA extraction and hybridization to microarrays from patients (n=362) with moderate-to-severe Crohn's disease and from non-IBD subjects (n=26).

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
388 GSM samples
 Primary source
recount3

Planned trusted source for processed count availability.

 No match found
Expression Atlas

Planned source for curated expression experiment links.

 No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

10 linked publications 10 DOIs

Primary publication

  1. Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology, 2018

Related publications

  1. Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease. Immunity, inflammation and disease, 2021
  2. Exploration of the shared gene signatures and potential molecular mechanisms between Crohn's disease and psoriasis. Clinical rheumatology, 2026
  3. The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1. Discover oncology, 2024
  4. Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease. Nature communications, 2024
  5. Identification and immune landscape of sarcopenia-related molecular clusters in inflammatory bowel disease by machine learning and integrated bioinformatics. Scientific reports, 2024
  6. Candidate Biomarkers for Crohn's Disease: Hub Genes and Regulatory miRNAs Identified by Bioinformatics Analysis. Biochemistry research international, 2026
  7. Immunological profile of lactylation-related genes in Crohn's disease: a comprehensive analysis based on bulk and single-cell RNA sequencing data. Journal of translational medicine, 2024
  8. Identification of immune related gene signature for predicting prognosis of cholangiocarcinoma patients. Frontiers in immunology, 2023
  9. Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn's disease. Frontiers in immunology, 2024
Available

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Ready after review
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

  • Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
  • Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Crohn's disease, inflammatory bowel disease Disease context came from Normalization rules.
  • Likely case group Treated 362 samples
  • Likely control group Healthy control 26 samples

Intent Interpretation

  • Downgrade or exclusion reason Downgraded for tissue search because it is a treatment/control experiment. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Comparison: Treatment vs control. Specimen: Biopsy. Comparison suitability: 0%.
  • Interpreted disease metadata: Crohn's disease, Inflammatory bowel disease.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 10 publications; 10 DOIs available: PMID 29782846, PMID 34469062, PMID 36817485, PMID 38521905, PMID 38840917.
  • Publication context: Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease.. Gastroenterology, 2018. PMID 29782846. DOI 10.1053/j.gastro.2018.05.028.
  • Publication context: Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease.. Immunity, inflammation and disease, 2021. PMID 34469062. DOI 10.1002/iid3.506.
  • Publication context: Identification of immune related gene signature for predicting prognosis of cholangiocarcinoma patients.. Frontiers in immunology, 2023. PMID 36817485. DOI 10.3389/fimmu.2023.1028404.
  • Publication context: 7 additional linked PubMed publications are available.

Cautions

  • Downgraded for tissue search because it is a treatment/control experiment.
  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Treatment/control experiment downgraded because this ranking targets tumor-vs-normal tissue comparisons.
  • Microarray expression context downgraded below primary bulk RNA-seq for the default tissue ranking.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because microarray cohorts should be compared separately from RNA-seq cohorts.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

showing 500 of 2247 fields

Sample Group Preview

showing 76 of 388 preview rows Show Hide
Study totals: Case 362 | Control 26 | Unassigned 0 | Excluded 0 | Ambiguous 0 showing 76 of 388 preview rows
Group Role Accession Title Source / characteristics Reason
Treated Case GSM3068409 CNTO1275CRD3002-20149 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20149; Treatment_induction: Pbo; Treatment_maintenance: .; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068410 CNTO1275CRD3002-20963 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20963; Treatment_induction: Pbo; Treatment_maintenance: .; Visit: I-WK0; I-wk8 response: N; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068411 CNTO1275CRD3002-20577 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20577; Treatment_induction: Pbo; Treatment_maintenance: .; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 8; Ileummvilli_length: 1.14 Explicit characteristic comparison arm detected.
Treated Case GSM3068412 CNTO1275CRD3002-20631 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20631; Treatment_induction: Pbo; Treatment_maintenance: .; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 7; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068413 CNTO1275CRD3002-20367 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20367; Treatment_induction: Pbo; Treatment_maintenance: .; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: 1.26 Explicit characteristic comparison arm detected.
Treated Case GSM3068414 CNTO1275CRD3002-20829 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20829; Treatment_induction: Pbo; Treatment_maintenance: .; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: 1.6 Explicit characteristic comparison arm detected.
Treated Case GSM3068415 CNTO1275CRD3002-20346 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20346; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 3; Ileummvilli_length: 1.68 Explicit characteristic comparison arm detected.
Treated Case GSM3068416 CNTO1275CRD3002-20441 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20441; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 11; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068417 CNTO1275CRD3002-20484 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20484; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068418 CNTO1275CRD3002-20429 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20429; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Colon only; Ileum ses-cd score: 3; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068419 CNTO1275CRD3002-20757 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20757; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068420 CNTO1275CRD3002-20239 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20239; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 6; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068421 CNTO1275CRD3002-20678 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20678; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 5; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068422 CNTO1275CRD3002-20865 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20865; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068423 CNTO1275CRD3002-20604 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20604; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068424 CNTO1275CRD3002-20637 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20637; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068425 CNTO1275CRD3002-20290 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20290; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: 1.63 Explicit characteristic comparison arm detected.
Treated Case GSM3068426 CNTO1275CRD3002-20090 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20090; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068427 CNTO1275CRD3002-20547 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20547; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: 1.31 Explicit characteristic comparison arm detected.
Treated Case GSM3068428 CNTO1275CRD3002-20336 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20336; Treatment_induction: Pbo; Treatment_maintenance: Discontinued; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068429 CNTO1275CRD3002-20408 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20408; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum only; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068430 CNTO1275CRD3002-20072 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20072; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: 1.47 Explicit characteristic comparison arm detected.
Treated Case GSM3068431 CNTO1275CRD3002-20291 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20291; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: 1.33 Explicit characteristic comparison arm detected.
Treated Case GSM3068432 CNTO1275CRD3002-20196 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20196; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: 1.65 Explicit characteristic comparison arm detected.
Treated Case GSM3068433 CNTO1275CRD3002-20616 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20616; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068434 CNTO1275CRD3002-20978 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20978; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068435 CNTO1275CRD3002-20176 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20176; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: 6; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068436 CNTO1275CRD3002-20504 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20504; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 9; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068437 CNTO1275CRD3002-20244 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20244; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: 1.37 Explicit characteristic comparison arm detected.
Treated Case GSM3068438 CNTO1275CRD3002-20231 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20231; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: 1.47 Explicit characteristic comparison arm detected.
Treated Case GSM3068439 CNTO1275CRD3002-20732 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20732; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: 3; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068440 CNTO1275CRD3002-21043 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-21043; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: 1.12 Explicit characteristic comparison arm detected.
Treated Case GSM3068441 CNTO1275CRD3002-20432 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20432; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068442 CNTO1275CRD3002-20953 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20953; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum only; Ileum ses-cd score: 6; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068443 CNTO1275CRD3002-20791 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20791; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068444 CNTO1275CRD3002-20472 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20472; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: 1.4 Explicit characteristic comparison arm detected.
Treated Case GSM3068445 CNTO1275CRD3002-21035 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-21035; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068446 CNTO1275CRD3002-20959 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20959; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068447 CNTO1275CRD3002-20358 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20358; Treatment_induction: Pbo; Treatment_maintenance: Pbo; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068448 CNTO1275CRD3002-20301 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20301; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068449 CNTO1275CRD3002-20068 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20068; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 5; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068450 CNTO1275CRD3002-20679 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20679; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: Y; Gi involvement: Ileum and colon; Ileum ses-cd score: 4; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068451 CNTO1275CRD3002-20003 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20003; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 3; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068452 CNTO1275CRD3002-20009 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20009; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 0; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068453 CNTO1275CRD3002-20187 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20187; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: .; Ileummvilli_length: 1.55 Explicit characteristic comparison arm detected.
Treated Case GSM3068454 CNTO1275CRD3002-20805 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20805; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Colon only; Ileum ses-cd score: 0; Ileummvilli_length: 1.92 Explicit characteristic comparison arm detected.
Treated Case GSM3068455 CNTO1275CRD3002-20781 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20781; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum and colon; Ileum ses-cd score: 5; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068456 CNTO1275CRD3002-20395 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20395; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 3; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068457 CNTO1275CRD3002-20728 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20728; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 12; Ileummvilli_length: . Explicit characteristic comparison arm detected.
Treated Case GSM3068458 CNTO1275CRD3002-20565 I-WK0 ileum Ileum biopsy Tissue: Ileum; Diagnosis: Crohn's disease (CD); Subject: CNTO1275CRD3002-20565; Treatment_induction: Pbo; Treatment_maintenance: Ust12W; Visit: I-WK0; I-wk8 response: N; Gi involvement: Ileum only; Ileum ses-cd score: 4; Ileummvilli_length: 1.42 Explicit characteristic comparison arm detected.
312 additional case samples are hidden from this preview.
Healthy control Control GSM3068771 EFZ159583A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ159583A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068772 EFZ166972A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ166972A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068773 EFZ168281A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ168281A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068774 EFZ170759A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ170759A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068775 EFZ171541A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ171541A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068776 EFZ172297A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ172297A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068777 EFZ173508A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ173508A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068778 EFZ174605A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ174605A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068779 EFZ174673A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ174673A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068780 EFZ176281A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ176281A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068781 EFZ181273A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ181273A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068782 EFZ181312A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ181312A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068783 EFZ181564A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ181564A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068784 EFZ181631A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ181631A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068785 EFZ184192A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ184192A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068786 EFZ188395A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ188395A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068787 EFZ188703A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ188703A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068788 EFZ194887A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ194887A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068789 EFZ197138A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ197138A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068790 EFZ203383A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ203383A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068791 EFZ204935A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ204935A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068792 EFZ205063A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ205063A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068793 EFZ207317A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ207317A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068794 EFZ208692A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ208692A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068795 EFZ209642A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ209642A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.
Healthy control Control GSM3068796 EFZ216356A Normal ileum Ileum biopsy Tissue: Ileum; Diagnosis: Normal (non-IBD); Subject: EFZ216356A; Treatment_induction: Normal; Treatment_maintenance: Normal; Visit: Normal; I-wk8 response: Normal; Gi involvement: Normal; Ileum ses-cd score: .; Ileummvilli_length: . Explicit characteristic control arm detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.