GSE114591

A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq]

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

32 case / 6 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source: GEO
Assay: microarray
Organism: Homo sapiens
Whole-study samples: 38 samples
Specimen: Tissue
Reported/interpreted study design: Disease/model vs control Design classification does not establish patient pairs.

Comparison type: Tumor vs normal
Contributors: Lorén V, Garcia-Jaraquemada A, Naves J, Carmona X, Mañosa M, Aransay AM, Lavin J, Sánchez I, Cabré E, Manyé J, Domènech E
Contact name: Ana Maria Aransay
Submission date: 2018-05-17
Last update: 2019-02-07
Organization: CIC bioGUNE
Department: Genome Analysis Platform
Public date: 2018-11-06
Experiment types: Non-coding RNA profiling by high throughput sequencing
Platforms: GPL15456 Illumina HiScanSQ (Homo sapiens)
Series type: SubSeries
SubSeries: Not available
BioProject: PRJNA471862

Summary

BACKGROUND: Glucocorticoid (GC) refractoriness is a common and unpredictable phenomenon in ulcerative colitis (UC). Although it has been demonstrated that NFkB is involved in its mechanism of action (MoA), there are no conclusive studies on the molecular functions involved. The current study describes in depth the MoA related to GC failure, by integrating transcriptomic data from UC patients, and updated molecular data on UC and GC. METHODS: miRNA and mRNA expression from rectal biopsies of active UC patients, obtained before and on the 3rd day of GC treatment, were evaluated by sequencing and microarrays, respectively. The differential results obtained were integrated into the mathematical models generated by Systems Biology. RESULTS: This computational approach identified 64 proteins, among which 18 stand out, either by being associated to the MoA or by providing a major capacity to classify the patients according to GC response. The biological functions of these proteins have been linked with inflammation, machinery GC-induced transcription and angiogenesis. All the selected proteins but one —Acidic leucine-rich Nuclear Phosphoprotein 32 family member E (ANP32E) — had previously been related to UC and/or GC-induced biological actions. ANP32E has been linked to the exchange of H2A to H2A.z histone, which promotes CG receptor complex-activated transcription. Western blot and immunofluorescence assays confirmed the predictive results obtained by Systems Biology. CONCLUSIONS: A comprehensive MoA of GC refractoriness has been described, highlighting the key role of GC-induced transcription in this phenomenon. Several proteins have been identified as putative predictors of GC refractoriness.

Overall design

Intestinal tissue from individuals with or without active ulcerative colitis (AUC) was collected and, those with AUC were characterized for their capacity to response to glucocorticoids treatment. microRNAs and mRNAs profiles were studied for each sample by microRNAseq and gene expression microarray, respectively.

Source Evidence

4 sources

Source	Contribution	Status
GEO	Original dataset metadata, sample metadata, source links, and GEO data availability flags. Sample records 38 GSM samples	Primary source
recount3	Planned trusted source for processed count availability.	No match found
Expression Atlas	Planned source for curated expression experiment links.	No match found
PubMed	Primary GEO citations and related PubMed articles that mention this dataset. 1 linked publication 1 DOI Primary publication ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach. Journal of Crohn's & colitis, 2019 PubMed DOI	Available

Metadata Quality Components

Persisted metadata quality

100 pts

Clarity: 100%
Weight: 100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Review before analysis

97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal

Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
Disease context Ulcerative colitis Disease context came from Normalization rules.
Likely case group Ulcerative colitis 32 samples
Likely control group Healthy control 6 samples

Intent Interpretation

Downgrade or exclusion reason Downgraded assay: microarray cohorts are separated from the RNA-seq intent. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

Comparison: Disease/model vs control. Specimen: Tissue. Comparison suitability: 0%.
Interpreted disease metadata: Ulcerative colitis.
Processed data is available for downstream review.
External evidence: PubMed links 1 publication; 1 DOI available: PMID 30329026.
Publication context: ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach.. Journal of Crohn's & colitis, 2019. PMID 30329026. DOI 10.1093/ecco-jcc/jjy171.

Cautions

Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
Microarray expression context downgraded below primary bulk RNA-seq for the default tissue ranking.
Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
Overall score capped because comparison suitability is weak for the selected search intent.
Overall score capped because microarray cohorts should be compared separately from RNA-seq cohorts.
Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
Microarray expression context was detected; compare separately from RNA-seq cohorts.
Microarray datasets are downgraded in the patient-tissue tumor-normal intent unless secondary assays are explicitly enabled.

Normalized Fields

76 fields

Field Value Source Derived by Confidence Evidence Reason

assay_type bulk RNA-seq GSE114591 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence rna-seq dataset_accession: GSE114591 dataset_title: A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq] ... keyword match keyword match: rna-seq

assay_type microarray GSE114591 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence microarray dataset_accession: GSE114591 dataset_title: A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq] ... keyword match keyword match: microarray

disease ulcerative colitis GSE114591 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis dataset_accession: GSE114591 dataset_title: A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq] ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145433 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500904 [miRNA-Seq] D04 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145434 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500905 [miRNA-Seq] D05 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145435 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500906 [miRNA-Seq] D06 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145437 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500914 [miRNA-Seq] D14 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145438 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500916 [miRNA-Seq] D16 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145439 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500917 [miRNA-Seq] D17 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145440 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500919 [miRNA-Seq] D19 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145441 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500928 [miRNA-Seq] D28 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145442 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500929 [miRNA-Seq] D29 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145443 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500930 [miRNA-Seq] D30 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145444 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500931 [miRNA-Seq] D31 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145445 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500940 [miRNA-Seq] D40 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145446 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500941 [miRNA-Seq] D41 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145447 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500942 [miRNA-Seq] D42 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145448 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500943 [miRNA-Seq] D43 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145450 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500952 [miRNA-Seq] D52 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145451 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500953 [miRNA-Seq] D53 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145452 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500954 [miRNA-Seq] D54 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145453 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500955 [miRNA-Seq] D55 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145455 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500964 [miRNA-Seq] D64 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145456 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500965 [miRNA-Seq] D65 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145457 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500966 [miRNA-Seq] D66 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145458 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500967 [miRNA-Seq] D67 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145460 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500975 [miRNA-Seq] D75 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145461 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500976 [miRNA-Seq] D76 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145462 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500977 [miRNA-Seq] D77 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145463 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500978 [miRNA-Seq] D78 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids tand who... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145465 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500987 [miRNA-Seq] D87 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145466 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500988 [miRNA-Seq] D88 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145467 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500989 [miRNA-Seq] D89 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145468 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500990 [miRNA-Seq] D90 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM3145469 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis AAA0500991 [miRNA-Seq] D91 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary disease match: ulcerative colitis

organism Homo sapiens GSE114591 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence homo sapiens dataset_accession: GSE114591 dataset_title: A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq] ... keyword match keyword match: homo sapiens

tissue colon GSE114591 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence rectal dataset_accession: GSE114591 dataset_title: A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq] ... controlled vocabulary controlled vocabulary tissue match: rectal

tissue intestine GSE114591 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal dataset_accession: GSE114591 dataset_title: A systems biology approach identifies ANP32E and other biomarkers of glucocorticoid refractoriness in ulcerative colitis [miRNA-Seq] ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145432 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500902 [miRNA-Seq] D02 tissue: intestinal tissue; disease state: healthy controls; group: healthy controls controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145433 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500904 [miRNA-Seq] D04 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145434 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500905 [miRNA-Seq] D05 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145435 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500906 [miRNA-Seq] D06 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145436 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500907 [miRNA-Seq] D07 tissue: intestinal tissue; disease state: healthy controls; group: healthy controls controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145437 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500914 [miRNA-Seq] D14 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145438 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500916 [miRNA-Seq] D16 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145439 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500917 [miRNA-Seq] D17 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145440 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500919 [miRNA-Seq] D19 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145441 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500928 [miRNA-Seq] D28 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145442 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500929 [miRNA-Seq] D29 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145443 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500930 [miRNA-Seq] D30 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145444 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500931 [miRNA-Seq] D31 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145445 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500940 [miRNA-Seq] D40 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145446 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500941 [miRNA-Seq] D41 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145447 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500942 [miRNA-Seq] D42 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145448 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500943 [miRNA-Seq] D43 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145449 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500949 [miRNA-Seq] D49 tissue: intestinal tissue; disease state: healthy controls; group: healthy controls controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145450 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500952 [miRNA-Seq] D52 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145451 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500953 [miRNA-Seq] D53 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145452 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500954 [miRNA-Seq] D54 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145453 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500955 [miRNA-Seq] D55 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145454 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500961 [miRNA-Seq] D61 tissue: intestinal tissue; disease state: healthy controls; group: healthy controls controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145455 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500964 [miRNA-Seq] D64 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145456 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500965 [miRNA-Seq] D65 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145457 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500966 [miRNA-Seq] D66 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145458 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500967 [miRNA-Seq] D67 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145459 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500973 [miRNA-Seq] D73 tissue: intestinal tissue; disease state: healthy controls; group: healthy controls controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145460 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500975 [miRNA-Seq] D75 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145461 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500976 [miRNA-Seq] D76 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145462 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500977 [miRNA-Seq] D77 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids and who ... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145463 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500978 [miRNA-Seq] D78 tissue: intestinal tissue; disease state: ulcerative colitis; group: patients with active ulcerative colitis before receiving glucocorticoids tand who... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145464 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500985 [miRNA-Seq] D85 tissue: intestinal tissue; disease state: healthy controls; group: healthy controls controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145465 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500987 [miRNA-Seq] D87 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145466 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500988 [miRNA-Seq] D88 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145467 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500989 [miRNA-Seq] D89 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145468 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500990 [miRNA-Seq] D90 tissue: intestinal tissue; disease state: ulcerative colitis; group: third day of treatment in treatment-responders (R) patients controlled vocabulary controlled vocabulary tissue match: intestinal

tissue intestine GSM3145469 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal AAA0500991 [miRNA-Seq] D91 tissue: intestinal tissue; disease state: ulcerative colitis; group: Non-Responders (NR) patients collected on the 3rd day controlled vocabulary controlled vocabulary tissue match: intestinal

Sample Group Preview

38 rows shown Show Hide

Study totals: Case 32 | Control 6 | Unassigned 0 | Excluded 0 | Ambiguous 0 38 rows shown

Group	Role	Accession	Title	Source / characteristics	Reason
Ulcerative colitis	Case	GSM3145433	AAA0500904 [miRNA-Seq]	D04 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who will have a poor response to treatment (non-responders, NR)	Case marker detected.
Ulcerative colitis	Case	GSM3145434	AAA0500905 [miRNA-Seq]	D05 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who will have a poor response to treatment (non-responders, NR)	Case marker detected.
Ulcerative colitis	Case	GSM3145435	AAA0500906 [miRNA-Seq]	D06 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145437	AAA0500914 [miRNA-Seq]	D14 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145438	AAA0500916 [miRNA-Seq]	D16 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145439	AAA0500917 [miRNA-Seq]	D17 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145440	AAA0500919 [miRNA-Seq]	D19 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145441	AAA0500928 [miRNA-Seq]	D28 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145442	AAA0500929 [miRNA-Seq]	D29 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who will have a poor response to treatment (non-responders, NR)	Case marker detected.
Ulcerative colitis	Case	GSM3145443	AAA0500930 [miRNA-Seq]	D30 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145444	AAA0500931 [miRNA-Seq]	D31 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145445	AAA0500940 [miRNA-Seq]	D40 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145446	AAA0500941 [miRNA-Seq]	D41 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145447	AAA0500942 [miRNA-Seq]	D42 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145448	AAA0500943 [miRNA-Seq]	D43 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145450	AAA0500952 [miRNA-Seq]	D52 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145451	AAA0500953 [miRNA-Seq]	D53 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who will have a poor response to treatment (non-responders, NR)	Case marker detected.
Ulcerative colitis	Case	GSM3145452	AAA0500954 [miRNA-Seq]	D54 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145453	AAA0500955 [miRNA-Seq]	D55 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145455	AAA0500964 [miRNA-Seq]	D64 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145456	AAA0500965 [miRNA-Seq]	D65 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145457	AAA0500966 [miRNA-Seq]	D66 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145458	AAA0500967 [miRNA-Seq]	D67 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145460	AAA0500975 [miRNA-Seq]	D75 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who will have a poor response to treatment (non-responders, NR)	Case marker detected.
Ulcerative colitis	Case	GSM3145461	AAA0500976 [miRNA-Seq]	D76 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145462	AAA0500977 [miRNA-Seq]	D77 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids and who will have a poor response to treatment (non-responders, NR)	Case marker detected.
Ulcerative colitis	Case	GSM3145463	AAA0500978 [miRNA-Seq]	D78 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Patients with active ulcerative colitis before receiving glucocorticoids tand who have a good response to treatment (responders, R)	Case marker detected.
Ulcerative colitis	Case	GSM3145465	AAA0500987 [miRNA-Seq]	D87 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145466	AAA0500988 [miRNA-Seq]	D88 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145467	AAA0500989 [miRNA-Seq]	D89 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Ulcerative colitis	Case	GSM3145468	AAA0500990 [miRNA-Seq]	D90 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Third day of treatment in treatment-responders (R) patients	Case marker detected.
Ulcerative colitis	Case	GSM3145469	AAA0500991 [miRNA-Seq]	D91 Tissue: Intestinal tissue; Disease state: Ulcerative colitis; Group: Non-Responders (NR) patients collected on the 3rd day	Case marker detected.
Healthy control	Control	GSM3145432	AAA0500902 [miRNA-Seq]	D02 Tissue: Intestinal tissue; Disease state: Healthy controls; Group: Healthy controls	Sample-local control marker detected.
Healthy control	Control	GSM3145436	AAA0500907 [miRNA-Seq]	D07 Tissue: Intestinal tissue; Disease state: Healthy controls; Group: Healthy controls	Sample-local control marker detected.
Healthy control	Control	GSM3145449	AAA0500949 [miRNA-Seq]	D49 Tissue: Intestinal tissue; Disease state: Healthy controls; Group: Healthy controls	Sample-local control marker detected.
Healthy control	Control	GSM3145454	AAA0500961 [miRNA-Seq]	D61 Tissue: Intestinal tissue; Disease state: Healthy controls; Group: Healthy controls	Sample-local control marker detected.
Healthy control	Control	GSM3145459	AAA0500973 [miRNA-Seq]	D73 Tissue: Intestinal tissue; Disease state: Healthy controls; Group: Healthy controls	Sample-local control marker detected.
Healthy control	Control	GSM3145464	AAA0500985 [miRNA-Seq]	D85 Tissue: Intestinal tissue; Disease state: Healthy controls; Group: Healthy controls	Sample-local control marker detected.

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