GSE116044

miR-579-3p controls hepatocellular carcinoma formation by regulating the PI3K-AKT pathway in chronically inflamed liver (mRNA expression)

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

98 case / 0 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

Background & Aims: Chronic liver inflammation causes continuous liver damage with progressive liver fibrosis and cirrhosis, which may eventually lead to hepatocellular carcinoma (HCC). Whereas, the ten-year incidence for HCC in cirrhotic patients is approximately 20%, many cirrhotic patients remain tumor-free for their entire lives. Therefore, we wanted to clarify the mechanisms defining the different outcomes of chronic liver inflammation. Methods: We designed a longitudinal study comparing the mRNA and miRNA expression profiles in matched non-tumoral liver tissue from patients developing HCC (n = 30) versus patients remaining tumor-free (n = 27). The liver parenchyma was analyzed before and after HCC development in the same patient. Cirrhotic patients remaining tumor-free within a similar time frame served as a control cohort. mRNA expression of genes associated with cancer development and miRNAs were examined by the nCounterNanostring technology. The role of the identified genes involved in HCC development was evaluated by immunohistochemistry and in vitro assays. Results: Comparison of the two cohorts revealed that liver tissue from patients developing HCC displayed activation of NF-B, Insulin receptor and PI3K-AKT pathways, in parallel with increased hepatocyte proliferation and damage. Furthermore, downregulation of miR-579-3p was found as an early step in HCC development. MiR-579-3p directly attenuated PIK3CA expression and consequently AKT and pAKT. In vitro analyses confirmed that miR-579-3p controlled cell proliferation, migration and colony formation. Conclusions: Liver tissues from patients developing HCC revealed a more severe damage to the parenchyma with elevated hepatocyte proliferation. Moreover, miR-579-3p was identified as a potential novel tumor suppressor regulating PI3K-AKT signalling at the early stages of HCC development.

Overall design

In the study we analyzed mRNA expression by the nCounterNanostringPanCancer Pathways panel containing 730 cancer-associated genes in sequential liver biopsies from the same patient at two points in time: once when no hepatocellular carcinoma was present in the liver (1st biopsy) and once a hepatocellular tumor was present in the liver (2nd biopsy), in parallel we analyzed sequential biopsies from cirrhotic patients which remained tumor-free over a similar time free. 25 patients which developed hepatocellular carcinoma and 24 patients which remained tumor-free were included.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
98 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Publication context when PubMed identifiers are already known.

No match found

Metadata Quality Components

Analysis Readiness

Not ready
55% DE readiness

Contrast completeness

10/25 pts

Only one side of the contrast is present; downstream DE needs both groups.

Minimum group size

0/20 pts

Minimum group size cannot be evaluated until a complete contrast exists.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

0/10 pts

Critical warnings must be resolved before downstream analysis.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • No complete case/control contrast is available.
  • Critical dataset warnings must be resolved.
  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Resolve critical warnings before downstream analysis.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Blocked

No complete case/control grouping exists yet.

Review the sample grouping table and assign both case and control groups.

Minimum sample count met

Blocked

At least one group has fewer than 2 samples.

Choose a larger dataset or merge only scientifically valid groups.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

Analysis preparation checklist contains blocked items.

No complete case/control or treatment/control contrast is available.

At least one comparison group has fewer than two samples.

Critical dataset warnings are present.

Assay context may require expert handling before DESeq2-style analysis.

Study design is model-system or unclear and should be reviewed before analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Fibrosis, hepatocellular carcinoma, liver fibrosis Disease context came from Normalization rules.
  • Likely case group Liver fibrosis 98 samples
  • Likely control group No control group detected 0 samples

Intent Interpretation

  • Downgrade or exclusion reason Comparison: Unclear study design. Specimen: Biopsy. Comparison suitability: 0%. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Interpreted disease metadata: Fibrosis, Hepatocellular carcinoma, Liver fibrosis.
  • Processed data is available for downstream review.

Cautions

  • Comparison: Unclear study design. Specimen: Biopsy. Comparison suitability: 0%.
  • Downgraded for tissue search because study design or specimen source is unclear.
  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Unclear study design downgraded for patient tissue tumor-vs-normal search intent.
  • Missing or unclear metadata. Unclear study design downgraded for patient tissue tumor-vs-normal search intent.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Missing or unclear metadata. Comparison - Unclear study design. Specimen - Biopsy. Comparison suitability: 0%.
  • Missing or unclear metadata. Downgraded for tissue search because study design or specimen source is unclear.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

showing 500 of 692 fields

Sample Group Preview

showing 50 of 98 preview rows
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Study totals: Case 98 | Control 0 | Unassigned 0 | Excluded 0 | Ambiguous 0 showing 50 of 98 preview rows
Group Role Accession Title Source / characteristics Reason
Liver fibrosis Case GSM3208016 20150528_MatterCancerRun3_C3_03 HCC 1st Biopsy Patient.Id: 8; Tissue: Liver tissue; Fibrosis stage: F2; Age: 36; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208017 20150528_MatterCancerRun3_C4_04 HCC 2nd Biopsy Patient.Id: 8; Tissue: Liver tissue; Fibrosis stage: F4; Age: 45; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208018 20150528_MatterCancerRun4_D4_04 HCC 1st Biopsy Patient.Id: 9; Tissue: Liver tissue; Fibrosis stage: F4; Age: 51; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208019 20150528_MatterCancerRun4_D5_05 HCC 2nd Biopsy Patient.Id: 9; Tissue: Liver tissue; Fibrosis stage: F4; Age: 62; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208020 20150528_MatterCancerRun4_D7_07 HCC 1st Biopsy Patient.Id: 10; Tissue: Liver tissue; Fibrosis stage: F4; Age: 45; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208021 20150528_MatterCancerRun4_D8_08 HCC 2nd Biopsy Patient.Id: 10; Tissue: Liver tissue; Fibrosis stage: F4; Age: 51; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208022 20150528_MatterCancerRun4_D10_10 HCC 1st Biopsy Patient.Id: 11; Tissue: Liver tissue; Fibrosis stage: F4; Age: 34; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208023 20150528_MatterCancerRun4_D11_11 HCC 2nd Biopsy Patient.Id: 11; Tissue: Liver tissue; Fibrosis stage: F4; Age: 58; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208024 20150624_MatterCancerRun11_M4_04 HCC 1st Biopsy Patient.Id: 12; Tissue: Liver tissue; Fibrosis stage: F2; Age: 60; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208025 20150624_MatterCancerRun11_M5_05 HCC 2nd Biopsy Patient.Id: 12; Tissue: Liver tissue; Fibrosis stage: F4; Age: 69; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208026 20150528_MatterCancerRun3_C5_05 HCC 1st Biopsy Patient.Id: 13; Tissue: Liver tissue; Fibrosis stage: F2; Age: 57; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208027 20150528_MatterCancerRun3_C6_06 HCC 2nd Biopsy Patient.Id: 13; Tissue: Liver tissue; Fibrosis stage: F4; Age: 66; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208028 20150603_MatterCancerRun5_E1_01 HCC 1st Biopsy Patient.Id: 14; Tissue: Liver tissue; Fibrosis stage: F4; Age: 55; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208029 20150603_MatterCancerRun5_E2_02 HCC 2nd Biopsy Patient.Id: 14; Tissue: Liver tissue; Fibrosis stage: F4; Age: 61; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208030 20150603_MatterCancerRun5_E4_04 HCC 1st Biopsy Patient.Id: 16; Tissue: Liver tissue; Fibrosis stage: F4; Age: 60; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208031 20150603_MatterCancerRun5_E5_05 HCC 2nd Biopsy Patient.Id: 16; Tissue: Liver tissue; Fibrosis stage: F4; Age: 73; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208032 20150603_MatterCancerRun5_E6_06 HCC 1st Biopsy Patient.Id: 17; Tissue: Liver tissue; Fibrosis stage: F4; Age: 52; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208033 20150603_MatterCancerRun5_E7_07 HCC 2nd Biopsy Patient.Id: 17; Tissue: Liver tissue; Fibrosis stage: F4; Age: 63; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208034 20150603_MatterCancerRun5_E8_08 HCC 1st Biopsy Patient.Id: 18; Tissue: Liver tissue; Fibrosis stage: F4; Age: 60; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208035 20150603_MatterCancerRun5_E9_09 HCC 2nd Biopsy Patient.Id: 18; Tissue: Liver tissue; Fibrosis stage: F4; Age: 64; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208036 20150625_MatterCancerRun13_O5_05 HCC 1st Biopsy Patient.Id: 19; Tissue: Liver tissue; Fibrosis stage: F4; Age: 55; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208037 20150625_MatterCancerRun13_O6_06 HCC 2nd Biopsy Patient.Id: 19; Tissue: Liver tissue; Fibrosis stage: F4; Age: 57; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208038 20150603_MatterCancerRun6_F8_08 HCC 1st Biopsy Patient.Id: 21; Tissue: Liver tissue; Fibrosis stage: F1; Age: 39; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208039 20150603_MatterCancerRun6_F9_09 HCC 2nd Biopsy Patient.Id: 21; Tissue: Liver tissue; Fibrosis stage: F4; Age: 55; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208040 20150618_MatterCancerRun7postBo_G1_01 HCC 1st Biopsy Patient.Id: 22; Tissue: Liver tissue; Fibrosis stage: F3; Age: 37; Liver disease: Alcohol: FALSE; Liver disease: HCV: FALSE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208041 20150618_MatterCancerRun7postBo_G2_02 HCC 2nd Biopsy Patient.Id: 22; Tissue: Liver tissue; Fibrosis stage: F4; Age: 60; Liver disease: Alcohol: FALSE; Liver disease: HCV: FALSE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208042 20150625_MatterCancerRun13_O7_07 HCC 1st Biopsy Patient.Id: 28; Tissue: Liver tissue; Fibrosis stage: F4; Age: 60; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208043 20150625_MatterCancerRun13_O8_08 HCC 2nd Biopsy Patient.Id: 28; Tissue: Liver tissue; Fibrosis stage: F4; Age: 71; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208044 20150618_MatterCancerRun7postBo_G3_03 HCC 1st Biopsy Patient.Id: 29; Tissue: Liver tissue; Fibrosis stage: F2; Age: 45; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208045 20150618_MatterCancerRun7postBo_G4_04 HCC 2nd Biopsy Patient.Id: 29; Tissue: Liver tissue; Fibrosis stage: F4; Age: 56; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208046 20150527_MatterCancerRun1_A7_07 HCC 1st Biopsy Patient.Id: 33; Tissue: Liver tissue; Fibrosis stage: F4; Age: 44; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Liver fibrosis Case GSM3208047 20150527_MatterCancerRun1_A8_08 HCC 2nd Biopsy Patient.Id: 33; Tissue: Liver tissue; Fibrosis stage: F4; Age: 51; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Case marker detected.
Tumor sample Case GSM3208048 20150527_MatterCancerRun1_A9_09 Tumor-free 1st Biopsy Patient.Id: 34; Tissue: Liver tissue; Fibrosis stage: F4; Age: 47; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208049 20150527_MatterCancerRun1_A10_10 Tumor-free 2nd Biopsy Patient.Id: 34; Tissue: Liver tissue; Fibrosis stage: F4; Age: 51; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208050 20150527_MatterCancerRun1_A11_11 Tumor-free 1st Biopsy Patient.Id: 36; Tissue: Liver tissue; Fibrosis stage: F4; Age: 43; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208051 20150527_MatterCancerRun1_A12_12 Tumor-free 2nd Biopsy Patient.Id: 36; Tissue: Liver tissue; Fibrosis stage: F4; Age: 51; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208052 20150527_MatterCancerRun2_B7_07 Tumor-free 1st Biopsy Patient.Id: 37; Tissue: Liver tissue; Fibrosis stage: F4; Age: 44; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208053 20150527_MatterCancerRun2_B8_08 Tumor-free 2nd Biopsy Patient.Id: 37; Tissue: Liver tissue; Fibrosis stage: F4; Age: 49; Liver disease: Alcohol: FALSE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208054 20150527_MatterCancerRun2_B11_11 Tumor-free 1st Biopsy Patient.Id: 39; Tissue: Liver tissue; Fibrosis stage: F4; Age: 54; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208055 20150527_MatterCancerRun2_B12_12 Tumor-free 2nd Biopsy Patient.Id: 39; Tissue: Liver tissue; Fibrosis stage: F4; Age: 60; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208056 20150528_MatterCancerRun3_C7_07 Tumor-free 1st Biopsy Patient.Id: 40; Tissue: Liver tissue; Fibrosis stage: F4; Age: 42; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208057 20150528_MatterCancerRun3_C8_08 Tumor-free 2nd Biopsy Patient.Id: 40; Tissue: Liver tissue; Fibrosis stage: F2; Age: 54; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208058 20150528_MatterCancerRun3_C9_09 Tumor-free 1st Biopsy Patient.Id: 41; Tissue: Liver tissue; Fibrosis stage: F4; Age: 50; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208059 20150528_MatterCancerRun3_C10_10 Tumor-free 2nd Biopsy Patient.Id: 41; Tissue: Liver tissue; Fibrosis stage: F4; Age: 56; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208060 20150528_MatterCancerRun3_C11_11 Tumor-free 1st Biopsy Patient.Id: 43; Tissue: Liver tissue; Fibrosis stage: F4; Age: 51; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208061 20150528_MatterCancerRun3_C12_12 Tumor-free 2nd Biopsy Patient.Id: 43; Tissue: Liver tissue; Fibrosis stage: F4; Age: 59; Liver disease: Alcohol: TRUE; Liver disease: HCV: FALSE; Liver disease: HBV: TRUE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208062 20150603_MatterCancerRun6_F1_01 Tumor-free 1st Biopsy Patient.Id: 45; Tissue: Liver tissue; Fibrosis stage: F4; Age: 61; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208063 20150603_MatterCancerRun6_F2_02 Tumor-free 2nd Biopsy Patient.Id: 45; Tissue: Liver tissue; Fibrosis stage: F4; Age: 68; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208064 20150603_MatterCancerRun6_F3_03 Tumor-free 1st Biopsy Patient.Id: 46; Tissue: Liver tissue; Fibrosis stage: F4; Age: 38; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
Tumor sample Case GSM3208065 20150603_MatterCancerRun6_F4_04 Tumor-free 2nd Biopsy Patient.Id: 46; Tissue: Liver tissue; Fibrosis stage: F2; Age: 49; Liver disease: Alcohol: TRUE; Liver disease: HCV: TRUE; Liver disease: HBV: FALSE; Liver disease: PBC: FALSE Explicit sample label case marker detected.
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