Matching samples

GSE118587 · Expression data for participants in iWITH study at screening visit

Download matching samples CSV
Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

133 case / 0 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

The CSV contains only the confirmed cases and controls below. Excluded and uncertain samples are shown for review and are not exported.

These are sample eligibility decisions from the current indexed metadata. Study-level search filters and minimum sample counts do not establish expression quality or analysis readiness.

Included samples (0)

No samples meet the selected requirements. The CSV contains its column headers only.

Uncertain samples (133)

These samples need more evidence before they can be counted. This includes samples without a confirmed case/control role.

GSM3333765

Uncertain

SAMPLE 1

Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

Requirements and decision evidence
  • organism: Homo sapiens — Insufficient evidence
    • The required value is not reported.
    • assay type: bulk RNA-seq — Insufficient evidence
      • The required value is not reported.
      • specimen category: Tissue or biopsy — Insufficient evidence
        • The required value is not reported.
        • SAMPLE 1 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular...
        • SAMPLE 1 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular...
      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
        • Supported by the indexed evidence.
        • specimen category excludes: Biofluid — Insufficient evidence
          • The required value is not reported.
          • SAMPLE 1 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular...
          • SAMPLE 1 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular...
        Source metadata
        Source name
        Screening Visit_Cluster 2
        Characteristics
        tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None
        Description
        Not reported
        Indexed organism evidence
        INFERRED · PARENT_INHERITED: Not reported
        Indexed assay evidence
        INFERRED · PARENT_INHERITED: Not reported
        Source
        GEO
        Original indexed metadata
        sample_accession: GSM3333765
        sample_title: SAMPLE 1
        source_name: Screening Visit_Cluster 2
        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None

        GSM3333766

        Uncertain

        SAMPLE 2

        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

        Requirements and decision evidence
        • organism: Homo sapiens — Insufficient evidence
          • The required value is not reported.
          • assay type: bulk RNA-seq — Insufficient evidence
            • The required value is not reported.
            • specimen category: Tissue or biopsy — Insufficient evidence
              • The required value is not reported.
              • SAMPLE 2 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
              • SAMPLE 2 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
              • Supported by the indexed evidence.
              • specimen category excludes: Biofluid — Insufficient evidence
                • The required value is not reported.
                • SAMPLE 2 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
                • SAMPLE 2 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
              Source metadata
              Source name
              Screening Visit_Cluster 2
              Characteristics
              tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
              Description
              Not reported
              Indexed organism evidence
              INFERRED · PARENT_INHERITED: Not reported
              Indexed assay evidence
              INFERRED · PARENT_INHERITED: Not reported
              Source
              GEO
              Original indexed metadata
              sample_accession: GSM3333766
              sample_title: SAMPLE 2
              source_name: Screening Visit_Cluster 2
              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

              GSM3333767

              Uncertain

              SAMPLE 3

              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

              Requirements and decision evidence
              • organism: Homo sapiens — Insufficient evidence
                • The required value is not reported.
                • assay type: bulk RNA-seq — Insufficient evidence
                  • The required value is not reported.
                  • specimen category: Tissue or biopsy — Insufficient evidence
                    • The required value is not reported.
                    • SAMPLE 3 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                    • SAMPLE 3 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                    • Supported by the indexed evidence.
                    • specimen category excludes: Biofluid — Insufficient evidence
                      • The required value is not reported.
                      • SAMPLE 3 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                      • SAMPLE 3 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                    Source metadata
                    Source name
                    Screening Visit_Cluster 3
                    Characteristics
                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                    Description
                    Not reported
                    Indexed organism evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Indexed assay evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Source
                    GEO
                    Original indexed metadata
                    sample_accession: GSM3333767
                    sample_title: SAMPLE 3
                    source_name: Screening Visit_Cluster 3
                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                    GSM3333768

                    Uncertain

                    SAMPLE 4

                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                    Requirements and decision evidence
                    • organism: Homo sapiens — Insufficient evidence
                      • The required value is not reported.
                      • assay type: bulk RNA-seq — Insufficient evidence
                        • The required value is not reported.
                        • specimen category: Tissue or biopsy — Insufficient evidence
                          • The required value is not reported.
                          • SAMPLE 4 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                          • SAMPLE 4 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                          • Supported by the indexed evidence.
                          • specimen category excludes: Biofluid — Insufficient evidence
                            • The required value is not reported.
                            • SAMPLE 4 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                            • SAMPLE 4 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                          Source metadata
                          Source name
                          Screening Visit_Cluster 3
                          Characteristics
                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                          Description
                          Not reported
                          Indexed organism evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Indexed assay evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Source
                          GEO
                          Original indexed metadata
                          sample_accession: GSM3333768
                          sample_title: SAMPLE 4
                          source_name: Screening Visit_Cluster 3
                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                          GSM3333769

                          Uncertain

                          SAMPLE 5

                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                          Requirements and decision evidence
                          • organism: Homo sapiens — Insufficient evidence
                            • The required value is not reported.
                            • assay type: bulk RNA-seq — Insufficient evidence
                              • The required value is not reported.
                              • specimen category: Tissue or biopsy — Insufficient evidence
                                • The required value is not reported.
                                • SAMPLE 5 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular...
                                • SAMPLE 5 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular...
                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                • Supported by the indexed evidence.
                                • specimen category excludes: Biofluid — Insufficient evidence
                                  • The required value is not reported.
                                  • SAMPLE 5 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular...
                                  • SAMPLE 5 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular...
                                Source metadata
                                Source name
                                Screening Visit_Cluster 1
                                Characteristics
                                tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                Description
                                Not reported
                                Indexed organism evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Indexed assay evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Source
                                GEO
                                Original indexed metadata
                                sample_accession: GSM3333769
                                sample_title: SAMPLE 5
                                source_name: Screening Visit_Cluster 1
                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                GSM3333770

                                Uncertain

                                SAMPLE 6

                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                Requirements and decision evidence
                                • organism: Homo sapiens — Insufficient evidence
                                  • The required value is not reported.
                                  • assay type: bulk RNA-seq — Insufficient evidence
                                    • The required value is not reported.
                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                      • The required value is not reported.
                                      • SAMPLE 6 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                                      • SAMPLE 6 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                      • Supported by the indexed evidence.
                                      • specimen category excludes: Biofluid — Insufficient evidence
                                        • The required value is not reported.
                                        • SAMPLE 6 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                                        • SAMPLE 6 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular...
                                      Source metadata
                                      Source name
                                      Screening Visit_Cluster 3
                                      Characteristics
                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                      Description
                                      Not reported
                                      Indexed organism evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Indexed assay evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Source
                                      GEO
                                      Original indexed metadata
                                      sample_accession: GSM3333770
                                      sample_title: SAMPLE 6
                                      source_name: Screening Visit_Cluster 3
                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                      GSM3333771

                                      Uncertain

                                      SAMPLE 7

                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                      Requirements and decision evidence
                                      • organism: Homo sapiens — Insufficient evidence
                                        • The required value is not reported.
                                        • assay type: bulk RNA-seq — Insufficient evidence
                                          • The required value is not reported.
                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                            • The required value is not reported.
                                            • SAMPLE 7 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                            • SAMPLE 7 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                            • Supported by the indexed evidence.
                                            • specimen category excludes: Biofluid — Insufficient evidence
                                              • The required value is not reported.
                                              • SAMPLE 7 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                              • SAMPLE 7 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                            Source metadata
                                            Source name
                                            Screening Visit_Cluster 1
                                            Characteristics
                                            tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                            Description
                                            Not reported
                                            Indexed organism evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Indexed assay evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Source
                                            GEO
                                            Original indexed metadata
                                            sample_accession: GSM3333771
                                            sample_title: SAMPLE 7
                                            source_name: Screening Visit_Cluster 1
                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                            GSM3333772

                                            Uncertain

                                            SAMPLE 8

                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                            Requirements and decision evidence
                                            • organism: Homo sapiens — Insufficient evidence
                                              • The required value is not reported.
                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                • The required value is not reported.
                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                  • The required value is not reported.
                                                  • SAMPLE 8 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                                  • SAMPLE 8 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                  • Supported by the indexed evidence.
                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                    • The required value is not reported.
                                                    • SAMPLE 8 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                                    • SAMPLE 8 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular...
                                                  Source metadata
                                                  Source name
                                                  Screening Visit_Cluster 3
                                                  Characteristics
                                                  tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                  Description
                                                  Not reported
                                                  Indexed organism evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Indexed assay evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Source
                                                  GEO
                                                  Original indexed metadata
                                                  sample_accession: GSM3333772
                                                  sample_title: SAMPLE 8
                                                  source_name: Screening Visit_Cluster 3
                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                  GSM3333773

                                                  Uncertain

                                                  SAMPLE 9

                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                  Requirements and decision evidence
                                                  • organism: Homo sapiens — Insufficient evidence
                                                    • The required value is not reported.
                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                      • The required value is not reported.
                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                        • The required value is not reported.
                                                        • SAMPLE 9 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
                                                        • SAMPLE 9 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                        • Supported by the indexed evidence.
                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                          • The required value is not reported.
                                                          • SAMPLE 9 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
                                                          • SAMPLE 9 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular...
                                                        Source metadata
                                                        Source name
                                                        Screening Visit_Cluster 1
                                                        Characteristics
                                                        tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Moderate
                                                        Description
                                                        Not reported
                                                        Indexed organism evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Indexed assay evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Source
                                                        GEO
                                                        Original indexed metadata
                                                        sample_accession: GSM3333773
                                                        sample_title: SAMPLE 9
                                                        source_name: Screening Visit_Cluster 1
                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Moderate

                                                        GSM3333774

                                                        Uncertain

                                                        SAMPLE10

                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                        Requirements and decision evidence
                                                        • organism: Homo sapiens — Insufficient evidence
                                                          • The required value is not reported.
                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                            • The required value is not reported.
                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                              • The required value is not reported.
                                                              • SAMPLE10 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lob...
                                                              • SAMPLE10 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lob...
                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                              • Supported by the indexed evidence.
                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                • The required value is not reported.
                                                                • SAMPLE10 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lob...
                                                                • SAMPLE10 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lob...
                                                              Source metadata
                                                              Source name
                                                              Screening Visit_Cluster 2
                                                              Characteristics
                                                              tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                              Description
                                                              Not reported
                                                              Indexed organism evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Indexed assay evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Source
                                                              GEO
                                                              Original indexed metadata
                                                              sample_accession: GSM3333774
                                                              sample_title: SAMPLE10
                                                              source_name: Screening Visit_Cluster 2
                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                              GSM3333775

                                                              Uncertain

                                                              SAMPLE 11

                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                              Requirements and decision evidence
                                                              • organism: Homo sapiens — Insufficient evidence
                                                                • The required value is not reported.
                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                  • The required value is not reported.
                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                    • The required value is not reported.
                                                                    • SAMPLE 11 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                    • SAMPLE 11 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                    • Supported by the indexed evidence.
                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • SAMPLE 11 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                      • SAMPLE 11 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                    Source metadata
                                                                    Source name
                                                                    Screening Visit_Cluster 3
                                                                    Characteristics
                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                    Description
                                                                    Not reported
                                                                    Indexed organism evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Indexed assay evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Source
                                                                    GEO
                                                                    Original indexed metadata
                                                                    sample_accession: GSM3333775
                                                                    sample_title: SAMPLE 11
                                                                    source_name: Screening Visit_Cluster 3
                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                    GSM3333776

                                                                    Uncertain

                                                                    SAMPLE 12

                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                    Requirements and decision evidence
                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                        • The required value is not reported.
                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                          • The required value is not reported.
                                                                          • SAMPLE 12 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                          • SAMPLE 12 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                          • Supported by the indexed evidence.
                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • SAMPLE 12 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                            • SAMPLE 12 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                          Source metadata
                                                                          Source name
                                                                          Screening Visit_Cluster 2
                                                                          Characteristics
                                                                          tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: None
                                                                          Description
                                                                          Not reported
                                                                          Indexed organism evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Indexed assay evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Source
                                                                          GEO
                                                                          Original indexed metadata
                                                                          sample_accession: GSM3333776
                                                                          sample_title: SAMPLE 12
                                                                          source_name: Screening Visit_Cluster 2
                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: None

                                                                          GSM3333777

                                                                          Uncertain

                                                                          SAMPLE 13

                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                          Requirements and decision evidence
                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                              • The required value is not reported.
                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                • The required value is not reported.
                                                                                • SAMPLE 13 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                • SAMPLE 13 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                • Supported by the indexed evidence.
                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • SAMPLE 13 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                  • SAMPLE 13 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                Source metadata
                                                                                Source name
                                                                                Screening Visit_Cluster 3
                                                                                Characteristics
                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                Description
                                                                                Not reported
                                                                                Indexed organism evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Indexed assay evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Source
                                                                                GEO
                                                                                Original indexed metadata
                                                                                sample_accession: GSM3333777
                                                                                sample_title: SAMPLE 13
                                                                                source_name: Screening Visit_Cluster 3
                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                GSM3333778

                                                                                Uncertain

                                                                                SAMPLE 14

                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                Requirements and decision evidence
                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                    • The required value is not reported.
                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                      • The required value is not reported.
                                                                                      • SAMPLE 14 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                      • SAMPLE 14 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                      • Supported by the indexed evidence.
                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • SAMPLE 14 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                        • SAMPLE 14 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                      Source metadata
                                                                                      Source name
                                                                                      Screening Visit_Cluster 3
                                                                                      Characteristics
                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                      Description
                                                                                      Not reported
                                                                                      Indexed organism evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Indexed assay evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Source
                                                                                      GEO
                                                                                      Original indexed metadata
                                                                                      sample_accession: GSM3333778
                                                                                      sample_title: SAMPLE 14
                                                                                      source_name: Screening Visit_Cluster 3
                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                      GSM3333779

                                                                                      Uncertain

                                                                                      SAMPLE 15

                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                      Requirements and decision evidence
                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                          • The required value is not reported.
                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                            • The required value is not reported.
                                                                                            • SAMPLE 15 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                            • SAMPLE 15 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                            • Supported by the indexed evidence.
                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • SAMPLE 15 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                              • SAMPLE 15 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                            Source metadata
                                                                                            Source name
                                                                                            Screening Visit_Cluster 2
                                                                                            Characteristics
                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: None
                                                                                            Description
                                                                                            Not reported
                                                                                            Indexed organism evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Indexed assay evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Source
                                                                                            GEO
                                                                                            Original indexed metadata
                                                                                            sample_accession: GSM3333779
                                                                                            sample_title: SAMPLE 15
                                                                                            source_name: Screening Visit_Cluster 2
                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: None

                                                                                            GSM3333780

                                                                                            Uncertain

                                                                                            SAMPLE 16

                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                            Requirements and decision evidence
                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                • The required value is not reported.
                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                  • The required value is not reported.
                                                                                                  • SAMPLE 16 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                  • SAMPLE 16 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                  • Supported by the indexed evidence.
                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • SAMPLE 16 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                    • SAMPLE 16 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                  Source metadata
                                                                                                  Source name
                                                                                                  Screening Visit_Cluster 2
                                                                                                  Characteristics
                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                  Description
                                                                                                  Not reported
                                                                                                  Indexed organism evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Indexed assay evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Source
                                                                                                  GEO
                                                                                                  Original indexed metadata
                                                                                                  sample_accession: GSM3333780
                                                                                                  sample_title: SAMPLE 16
                                                                                                  source_name: Screening Visit_Cluster 2
                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                  GSM3333781

                                                                                                  Uncertain

                                                                                                  SAMPLE 17

                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                  Requirements and decision evidence
                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                      • The required value is not reported.
                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                        • The required value is not reported.
                                                                                                        • SAMPLE 17 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                        • SAMPLE 17 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                        • Supported by the indexed evidence.
                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • SAMPLE 17 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                          • SAMPLE 17 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                        Source metadata
                                                                                                        Source name
                                                                                                        Screening Visit_Cluster 3
                                                                                                        Characteristics
                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                        Description
                                                                                                        Not reported
                                                                                                        Indexed organism evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Indexed assay evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Source
                                                                                                        GEO
                                                                                                        Original indexed metadata
                                                                                                        sample_accession: GSM3333781
                                                                                                        sample_title: SAMPLE 17
                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                        GSM3333782

                                                                                                        Uncertain

                                                                                                        SAMPLE 18

                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                        Requirements and decision evidence
                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                            • The required value is not reported.
                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                              • The required value is not reported.
                                                                                                              • SAMPLE 18 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                              • SAMPLE 18 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                              • Supported by the indexed evidence.
                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • SAMPLE 18 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                • SAMPLE 18 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                              Source metadata
                                                                                                              Source name
                                                                                                              Screening Visit_Cluster 3
                                                                                                              Characteristics
                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                              Description
                                                                                                              Not reported
                                                                                                              Indexed organism evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Indexed assay evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Source
                                                                                                              GEO
                                                                                                              Original indexed metadata
                                                                                                              sample_accession: GSM3333782
                                                                                                              sample_title: SAMPLE 18
                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                              GSM3333783

                                                                                                              Uncertain

                                                                                                              SAMPLE 19

                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                              Requirements and decision evidence
                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                  • The required value is not reported.
                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                    • The required value is not reported.
                                                                                                                    • SAMPLE 19 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                    • SAMPLE 19 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                    • Supported by the indexed evidence.
                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • SAMPLE 19 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                      • SAMPLE 19 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                    Source metadata
                                                                                                                    Source name
                                                                                                                    Screening Visit_Cluster 3
                                                                                                                    Characteristics
                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                    Description
                                                                                                                    Not reported
                                                                                                                    Indexed organism evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Indexed assay evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Source
                                                                                                                    GEO
                                                                                                                    Original indexed metadata
                                                                                                                    sample_accession: GSM3333783
                                                                                                                    sample_title: SAMPLE 19
                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                    GSM3333784

                                                                                                                    Uncertain

                                                                                                                    SAMPLE 20

                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                    Requirements and decision evidence
                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                        • The required value is not reported.
                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                          • The required value is not reported.
                                                                                                                          • SAMPLE 20 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                          • SAMPLE 20 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                          • Supported by the indexed evidence.
                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • SAMPLE 20 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                            • SAMPLE 20 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                          Source metadata
                                                                                                                          Source name
                                                                                                                          Screening Visit_Cluster 3
                                                                                                                          Characteristics
                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                          Description
                                                                                                                          Not reported
                                                                                                                          Indexed organism evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Indexed assay evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Source
                                                                                                                          GEO
                                                                                                                          Original indexed metadata
                                                                                                                          sample_accession: GSM3333784
                                                                                                                          sample_title: SAMPLE 20
                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                          GSM3333785

                                                                                                                          Uncertain

                                                                                                                          SAMPLE 21

                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                          Requirements and decision evidence
                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                              • The required value is not reported.
                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                • The required value is not reported.
                                                                                                                                • SAMPLE 21 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                • SAMPLE 21 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • SAMPLE 21 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                  • SAMPLE 21 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                Source metadata
                                                                                                                                Source name
                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                Characteristics
                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                Description
                                                                                                                                Not reported
                                                                                                                                Indexed organism evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Indexed assay evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Source
                                                                                                                                GEO
                                                                                                                                Original indexed metadata
                                                                                                                                sample_accession: GSM3333785
                                                                                                                                sample_title: SAMPLE 21
                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                GSM3333786

                                                                                                                                Uncertain

                                                                                                                                SAMPLE 22

                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                Requirements and decision evidence
                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                    • The required value is not reported.
                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                      • The required value is not reported.
                                                                                                                                      • SAMPLE 22 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                      • SAMPLE 22 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • SAMPLE 22 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                        • SAMPLE 22 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                      Source metadata
                                                                                                                                      Source name
                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                      Characteristics
                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                      Description
                                                                                                                                      Not reported
                                                                                                                                      Indexed organism evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Indexed assay evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Source
                                                                                                                                      GEO
                                                                                                                                      Original indexed metadata
                                                                                                                                      sample_accession: GSM3333786
                                                                                                                                      sample_title: SAMPLE 22
                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                      GSM3333787

                                                                                                                                      Uncertain

                                                                                                                                      SAMPLE 23

                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                      Requirements and decision evidence
                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                          • The required value is not reported.
                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                            • The required value is not reported.
                                                                                                                                            • SAMPLE 23 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                            • SAMPLE 23 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • SAMPLE 23 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                              • SAMPLE 23 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                            Source metadata
                                                                                                                                            Source name
                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                            Characteristics
                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                            Description
                                                                                                                                            Not reported
                                                                                                                                            Indexed organism evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Indexed assay evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Source
                                                                                                                                            GEO
                                                                                                                                            Original indexed metadata
                                                                                                                                            sample_accession: GSM3333787
                                                                                                                                            sample_title: SAMPLE 23
                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                            GSM3333788

                                                                                                                                            Uncertain

                                                                                                                                            SAMPLE 24

                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                            Requirements and decision evidence
                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                • The required value is not reported.
                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                  • The required value is not reported.
                                                                                                                                                  • SAMPLE 24 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                  • SAMPLE 24 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • SAMPLE 24 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                    • SAMPLE 24 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                  Source metadata
                                                                                                                                                  Source name
                                                                                                                                                  Screening Visit_Cluster 3
                                                                                                                                                  Characteristics
                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                  Description
                                                                                                                                                  Not reported
                                                                                                                                                  Indexed organism evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Indexed assay evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Source
                                                                                                                                                  GEO
                                                                                                                                                  Original indexed metadata
                                                                                                                                                  sample_accession: GSM3333788
                                                                                                                                                  sample_title: SAMPLE 24
                                                                                                                                                  source_name: Screening Visit_Cluster 3
                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                  GSM3333789

                                                                                                                                                  Uncertain

                                                                                                                                                  SAMPLE 25

                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                      • The required value is not reported.
                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                        • The required value is not reported.
                                                                                                                                                        • SAMPLE 25 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                        • SAMPLE 25 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                          • The required value is not reported.
                                                                                                                                                          • SAMPLE 25 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                          • SAMPLE 25 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                        Source metadata
                                                                                                                                                        Source name
                                                                                                                                                        Screening Visit_Cluster 1
                                                                                                                                                        Characteristics
                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                        Description
                                                                                                                                                        Not reported
                                                                                                                                                        Indexed organism evidence
                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                        Indexed assay evidence
                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                        Source
                                                                                                                                                        GEO
                                                                                                                                                        Original indexed metadata
                                                                                                                                                        sample_accession: GSM3333789
                                                                                                                                                        sample_title: SAMPLE 25
                                                                                                                                                        source_name: Screening Visit_Cluster 1
                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                        GSM3333790

                                                                                                                                                        Uncertain

                                                                                                                                                        SAMPLE 26

                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                          • The required value is not reported.
                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                            • The required value is not reported.
                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                              • The required value is not reported.
                                                                                                                                                              • SAMPLE 26 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                              • SAMPLE 26 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                • SAMPLE 26 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                • SAMPLE 26 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                              Source metadata
                                                                                                                                                              Source name
                                                                                                                                                              Screening Visit_Cluster 2
                                                                                                                                                              Characteristics
                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                              Description
                                                                                                                                                              Not reported
                                                                                                                                                              Indexed organism evidence
                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                              Indexed assay evidence
                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                              Source
                                                                                                                                                              GEO
                                                                                                                                                              Original indexed metadata
                                                                                                                                                              sample_accession: GSM3333790
                                                                                                                                                              sample_title: SAMPLE 26
                                                                                                                                                              source_name: Screening Visit_Cluster 2
                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                              GSM3333791

                                                                                                                                                              Uncertain

                                                                                                                                                              SAMPLE 27

                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                    • SAMPLE 27 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                    • SAMPLE 27 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                      • SAMPLE 27 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                      • SAMPLE 27 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                    Source metadata
                                                                                                                                                                    Source name
                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                    Characteristics
                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                    Description
                                                                                                                                                                    Not reported
                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                    Source
                                                                                                                                                                    GEO
                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                    sample_accession: GSM3333791
                                                                                                                                                                    sample_title: SAMPLE 27
                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                    GSM3333792

                                                                                                                                                                    Uncertain

                                                                                                                                                                    SAMPLE 28

                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                          • SAMPLE 28 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                          • SAMPLE 28 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                            • SAMPLE 28 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                            • SAMPLE 28 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                          Source metadata
                                                                                                                                                                          Source name
                                                                                                                                                                          Screening Visit_Cluster 2
                                                                                                                                                                          Characteristics
                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                          Description
                                                                                                                                                                          Not reported
                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                          Source
                                                                                                                                                                          GEO
                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                          sample_accession: GSM3333792
                                                                                                                                                                          sample_title: SAMPLE 28
                                                                                                                                                                          source_name: Screening Visit_Cluster 2
                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                          GSM3333793

                                                                                                                                                                          Uncertain

                                                                                                                                                                          SAMPLE 29

                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                • SAMPLE 29 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                • SAMPLE 29 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                  • SAMPLE 29 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                  • SAMPLE 29 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                Source metadata
                                                                                                                                                                                Source name
                                                                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                                                                Characteristics
                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                Description
                                                                                                                                                                                Not reported
                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Source
                                                                                                                                                                                GEO
                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                sample_accession: GSM3333793
                                                                                                                                                                                sample_title: SAMPLE 29
                                                                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                GSM3333794

                                                                                                                                                                                Uncertain

                                                                                                                                                                                SAMPLE 30

                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                      • SAMPLE 30 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                      • SAMPLE 30 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                        • SAMPLE 30 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                        • SAMPLE 30 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                      Source metadata
                                                                                                                                                                                      Source name
                                                                                                                                                                                      Screening Visit_Cluster 2
                                                                                                                                                                                      Characteristics
                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                      Description
                                                                                                                                                                                      Not reported
                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                      Source
                                                                                                                                                                                      GEO
                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                      sample_accession: GSM3333794
                                                                                                                                                                                      sample_title: SAMPLE 30
                                                                                                                                                                                      source_name: Screening Visit_Cluster 2
                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                      GSM3333795

                                                                                                                                                                                      Uncertain

                                                                                                                                                                                      SAMPLE 31

                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                            • SAMPLE 31 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                            • SAMPLE 31 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                              • SAMPLE 31 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                              • SAMPLE 31 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                            Source metadata
                                                                                                                                                                                            Source name
                                                                                                                                                                                            Screening Visit_Cluster 2
                                                                                                                                                                                            Characteristics
                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                            Description
                                                                                                                                                                                            Not reported
                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                            Source
                                                                                                                                                                                            GEO
                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                            sample_accession: GSM3333795
                                                                                                                                                                                            sample_title: SAMPLE 31
                                                                                                                                                                                            source_name: Screening Visit_Cluster 2
                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                            GSM3333796

                                                                                                                                                                                            Uncertain

                                                                                                                                                                                            SAMPLE 32

                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                  • SAMPLE 32 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                  • SAMPLE 32 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                    • SAMPLE 32 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                    • SAMPLE 32 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                  Source name
                                                                                                                                                                                                  Screening Visit_Cluster 3
                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                  Description
                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                  Source
                                                                                                                                                                                                  GEO
                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                  sample_accession: GSM3333796
                                                                                                                                                                                                  sample_title: SAMPLE 32
                                                                                                                                                                                                  source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                  GSM3333797

                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                  SAMPLE 33

                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                        • SAMPLE 33 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                        • SAMPLE 33 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                          • SAMPLE 33 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                          • SAMPLE 33 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                        Source name
                                                                                                                                                                                                        Screening Visit_Cluster 1
                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                        Description
                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                        Source
                                                                                                                                                                                                        GEO
                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                        sample_accession: GSM3333797
                                                                                                                                                                                                        sample_title: SAMPLE 33
                                                                                                                                                                                                        source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                        GSM3333798

                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                        SAMPLE 34

                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                              • SAMPLE 34 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                              • SAMPLE 34 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                • SAMPLE 34 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                • SAMPLE 34 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                              Source name
                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                              Description
                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Source
                                                                                                                                                                                                              GEO
                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                              sample_accession: GSM3333798
                                                                                                                                                                                                              sample_title: SAMPLE 34
                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                              GSM3333799

                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                              SAMPLE 35

                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                    • SAMPLE 35 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                    • SAMPLE 35 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                      • SAMPLE 35 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                      • SAMPLE 35 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                    sample_accession: GSM3333799
                                                                                                                                                                                                                    sample_title: SAMPLE 35
                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                    GSM3333800

                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                    SAMPLE 36

                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                          • SAMPLE 36 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                          • SAMPLE 36 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                            • SAMPLE 36 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                            • SAMPLE 36 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                          Screening Visit_Cluster 2
                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                          sample_accession: GSM3333800
                                                                                                                                                                                                                          sample_title: SAMPLE 36
                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                          GSM3333801

                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                          SAMPLE 37

                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                • SAMPLE 37 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                • SAMPLE 37 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                  • SAMPLE 37 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                  • SAMPLE 37 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                Screening Visit_Cluster 3
                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                sample_accession: GSM3333801
                                                                                                                                                                                                                                sample_title: SAMPLE 37
                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                GSM3333802

                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                SAMPLE 38

                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                      • SAMPLE 38 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                      • SAMPLE 38 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                        • SAMPLE 38 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                        • SAMPLE 38 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                      sample_accession: GSM3333802
                                                                                                                                                                                                                                      sample_title: SAMPLE 38
                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                      GSM3333803

                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                      SAMPLE 39

                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                            • SAMPLE 39 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                            • SAMPLE 39 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                              • SAMPLE 39 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                              • SAMPLE 39 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                            Screening Visit_Cluster 1
                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Moderate
                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                            sample_accession: GSM3333803
                                                                                                                                                                                                                                            sample_title: SAMPLE 39
                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Moderate

                                                                                                                                                                                                                                            GSM3333804

                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                            SAMPLE 40

                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                  • SAMPLE 40 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                  • SAMPLE 40 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                    • SAMPLE 40 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                    • SAMPLE 40 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                  Screening Visit_Cluster 2
                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                  sample_accession: GSM3333804
                                                                                                                                                                                                                                                  sample_title: SAMPLE 40
                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                  GSM3333805

                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                  SAMPLE 41

                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                        • SAMPLE 41 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                        • SAMPLE 41 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                          • SAMPLE 41 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                          • SAMPLE 41 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                        Screening Visit_Cluster 3
                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                        sample_accession: GSM3333805
                                                                                                                                                                                                                                                        sample_title: SAMPLE 41
                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                        GSM3333806

                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                        SAMPLE 42

                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                              • SAMPLE 42 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                              • SAMPLE 42 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                • SAMPLE 42 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                • SAMPLE 42 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                              sample_accession: GSM3333806
                                                                                                                                                                                                                                                              sample_title: SAMPLE 42
                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                              GSM3333807

                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                              SAMPLE 43

                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                    • SAMPLE 43 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                    • SAMPLE 43 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                      • SAMPLE 43 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                      • SAMPLE 43 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                    Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                    sample_accession: GSM3333807
                                                                                                                                                                                                                                                                    sample_title: SAMPLE 43
                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                    GSM3333808

                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                    SAMPLE 44

                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                          • SAMPLE 44 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                          • SAMPLE 44 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                            • SAMPLE 44 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                            • SAMPLE 44 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                          Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                          sample_accession: GSM3333808
                                                                                                                                                                                                                                                                          sample_title: SAMPLE 44
                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                          GSM3333809

                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                          SAMPLE 45

                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                • SAMPLE 45 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                • SAMPLE 45 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                  • SAMPLE 45 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                  • SAMPLE 45 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                sample_accession: GSM3333809
                                                                                                                                                                                                                                                                                sample_title: SAMPLE 45
                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                GSM3333810

                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                SAMPLE 46

                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                      • SAMPLE 46 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                      • SAMPLE 46 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                        • SAMPLE 46 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                        • SAMPLE 46 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: None
                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                      sample_accession: GSM3333810
                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 46
                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: None

                                                                                                                                                                                                                                                                                      GSM3333811

                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                      SAMPLE 47

                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                            • SAMPLE 47 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                            • SAMPLE 47 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                              • SAMPLE 47 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                              • SAMPLE 47 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: None
                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                            sample_accession: GSM3333811
                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 47
                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: None

                                                                                                                                                                                                                                                                                            GSM3333812

                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                            SAMPLE 48

                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                  • SAMPLE 48 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                  • SAMPLE 48 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                    • SAMPLE 48 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                    • SAMPLE 48 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333812
                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 48
                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                  GSM3333813

                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                  SAMPLE 49

                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                        • SAMPLE 49 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                        • SAMPLE 49 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                          • SAMPLE 49 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                          • SAMPLE 49 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333813
                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 49
                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                        GSM3333814

                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                        SAMPLE 50

                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                              • SAMPLE 50 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                              • SAMPLE 50 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                • SAMPLE 50 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                • SAMPLE 50 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333814
                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 50
                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                              GSM3333815

                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                              SAMPLE 51

                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                    • SAMPLE 51 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                    • SAMPLE 51 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                      • SAMPLE 51 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                      • SAMPLE 51 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333815
                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 51
                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                    GSM3333816

                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                    SAMPLE 52

                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                          • SAMPLE 52 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                          • SAMPLE 52 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                            • SAMPLE 52 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                            • SAMPLE 52 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333816
                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 52
                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                          GSM3333817

                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                          SAMPLE 53

                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                • SAMPLE 53 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                • SAMPLE 53 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                  • SAMPLE 53 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                  • SAMPLE 53 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333817
                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 53
                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                GSM3333818

                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                SAMPLE 54

                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                      • SAMPLE 54 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                      • SAMPLE 54 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                        • SAMPLE 54 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                        • SAMPLE 54 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333818
                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 54
                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                      GSM3333819

                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                      SAMPLE 55

                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                            • SAMPLE 55 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                            • SAMPLE 55 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                              • SAMPLE 55 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                              • SAMPLE 55 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333819
                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 55
                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                            GSM3333820

                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                            SAMPLE 56

                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 56 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 56 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 56 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 56 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333820
                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 56
                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                  GSM3333821

                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                  SAMPLE 57

                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 57 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 57 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 57 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 57 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333821
                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 57
                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                        GSM3333822

                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                        SAMPLE 58

                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 58 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 58 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 58 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 58 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333822
                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 58
                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                              GSM3333823

                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                              SAMPLE 59

                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 59 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 59 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 59 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 59 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333823
                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 59
                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                    GSM3333824

                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 60

                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 60 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 60 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 60 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 60 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333824
                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 60
                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                          GSM3333825

                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 61

                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 61 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 61 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 61 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 61 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333825
                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 61
                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                GSM3333826

                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 62

                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 62 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 62 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 62 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 62 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333826
                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 62
                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                      GSM3333827

                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 63

                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 63 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 63 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 63 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 63 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333827
                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 63
                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                            GSM3333828

                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 64

                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 64 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 64 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 64 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 64 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333828
                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 64
                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333829

                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 65

                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 65 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 65 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 65 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 65 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Moderate
                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333829
                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 65
                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Moderate

                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333830

                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 66

                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 66 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 66 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 66 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 66 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333830
                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 66
                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333831

                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 67

                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 67 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 67 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 67 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 67 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333831
                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 67
                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333832

                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 68

                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 68 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 68 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 68 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 68 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333832
                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 68
                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333833

                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 69

                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 69 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 69 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 69 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 69 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333833
                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 69
                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333834

                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 70

                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 70 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 70 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 70 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 70 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333834
                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 70
                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333835

                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 71

                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 71 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 71 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 71 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 71 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333835
                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 71
                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333836

                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 72

                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 72 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 72 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 72 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 72 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333836
                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 72
                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333837

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 73

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 73 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 73 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 73 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 73 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333837
                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 73
                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333838

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 74

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 74 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 74 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 74 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 74 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333838
                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 74
                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333839

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 75

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 75 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 75 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 75 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 75 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333839
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 75
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333840

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 76

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 76 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 76 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 76 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 76 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333840
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 76
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333841

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 77

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 77 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 77 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 77 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 77 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333841
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 77
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333842

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 78

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 78 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 78 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 78 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 78 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333842
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 78
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333843

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 79

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 79 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 79 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 79 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 79 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333843
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 79
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333844

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 80

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 80 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 80 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 80 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 80 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333844
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 80
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333845

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 81

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 81 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 81 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 81 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 81 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333845
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 81
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333846

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 82

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 82 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 82 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 82 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 82 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333846
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 82
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333847

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 83

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 83 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 83 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 83 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 83 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333847
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 83
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333848

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 84

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 84 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Severe; ishak fibrosis stage: 1; lobu...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 84 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Severe; ishak fibrosis stage: 1; lobu...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 84 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Severe; ishak fibrosis stage: 1; lobu...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 84 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Severe; ishak fibrosis stage: 1; lobu...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Severe; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333848
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 84
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Severe; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333849

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 85

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 85 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 85 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 85 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 85 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333849
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 85
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333850

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 86

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 86 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 86 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 86 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 86 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333850
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 86
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333851

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 87

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 87 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 87 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 87 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 87 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333851
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 87
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: None; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333852

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 88

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 88 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 88 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 88 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 88 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333852
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 88
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333853

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 89

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 89 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 89 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 89 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 89 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333853
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 89
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333854

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 90

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 90 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 90 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 90 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 90 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333854
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 90
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333855

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 91

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 91 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 91 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 91 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 91 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333855
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 91
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333856

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 92

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 92 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 92 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 92 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 92 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333856
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 92
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333857

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 93

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 93 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 93 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 93 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 93 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333857
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 93
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333858

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 94

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 94 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 94 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 94 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 94 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333858
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 94
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333859

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 95

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 95 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 95 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 95 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 95 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333859
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 95
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333860

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 96

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 96 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 96 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 96 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 96 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333860
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 96
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333861

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 97

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 97 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 97 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 97 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 97 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333861
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 97
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333862

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 98

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 98 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 98 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 98 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 98 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lo...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Moderate
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333862
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 98
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Moderate

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333863

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 99

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 99 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 99 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 99 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 99 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobula...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333863
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 99
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333864

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 100

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 100 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 100 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 100 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 100 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333864
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 100
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333865

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 101

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 101 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 101 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 101 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 101 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333865
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 101
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333866

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 102

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 102 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 102 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 102 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 102 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333866
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 102
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333867

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 103

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 103 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 103 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 103 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 103 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333867
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 103
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333868

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 104

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 104 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 104 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 104 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 104 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333868
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 104
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333869

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 105

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 105 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 105 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 105 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 105 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333869
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 105
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333870

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 106

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 106 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 106 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 106 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 106 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333870
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 106
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333871

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 107

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 107 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 107 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 107 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 107 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333871
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 107
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333872

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 108

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 108 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 108 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 108 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 108 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333872
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 108
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333873

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 109

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 109 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 109 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 109 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 109 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333873
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 109
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333874

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 110

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 110 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 110 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 110 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 110 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333874
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 110
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333875

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 111

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 111 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 111 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 111 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 111 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333875
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 111
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333876

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 112

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 112 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 112 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 112 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 112 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333876
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 112
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333877

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 113

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 113 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 113 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 113 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 113 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: Mild; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333877
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 113
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: Mild; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333878

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 114

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 114 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 114 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 114 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 114 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333878
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 114
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333879

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 115

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 115 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 115 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 115 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 115 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333879
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 115
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333880

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 116

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 116 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Moderate; perivenular fibrosis: Moderate; ishak fibrosis stage: ...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 116 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Moderate; perivenular fibrosis: Moderate; ishak fibrosis stage: ...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 116 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Moderate; perivenular fibrosis: Moderate; ishak fibrosis stage: ...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 116 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Moderate; perivenular fibrosis: Moderate; ishak fibrosis stage: ...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Moderate; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Moderate
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333880
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 116
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Moderate; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Moderate

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333881

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 117

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 117 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 117 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 117 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 117 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333881
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 117
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333882

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 118

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 118 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 118 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 118 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 118 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: Moderate; portal inflammation: Moderate
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333882
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 118
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 2; lobular inflammation: Moderate; portal inflammation: Moderate

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333883

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 119

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 119 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 119 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 119 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 119 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333883
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 119
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333884

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 120

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 120 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 120 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 120 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 120 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333884
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 120
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333885

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 121

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 121 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 121 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 121 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 121 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333885
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 121
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333886

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 122

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 122 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 122 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 122 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 122 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333886
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 122
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333887

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 123

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 123 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 123 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 123 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 123 Screening Visit_Cluster 2 tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333887
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 123
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 2; interface activity: None; perivenular fibrosis: Moderate; ishak fibrosis stage: 1; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333888

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 124

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 124 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 124 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 124 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 124 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333888
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 124
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 3; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333889

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 125

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 125 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 125 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 125 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 125 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333889
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 125
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM3333890

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SAMPLE 126

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 126 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 126 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 126 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 126 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM3333890
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: SAMPLE 126
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Mild; ishak fibrosis stage: 2; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM3333891

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SAMPLE 127

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 127 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 127 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 127 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 127 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM3333891
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: SAMPLE 127
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM3333892

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SAMPLE 128

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 128 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 128 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 128 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 128 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM3333892
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: SAMPLE 128
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM3333893

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SAMPLE 129

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 129 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • SAMPLE 129 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 129 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 129 Screening Visit_Cluster 1 tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; l...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM3333893
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: SAMPLE 129
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Screening Visit_Cluster 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Liver Biopsy; histological clusters: Cluster 1; interface activity: Mild; perivenular fibrosis: Moderate; ishak fibrosis stage: 3; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM3333894

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        SAMPLE 130

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 130 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SAMPLE 130 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 130 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 130 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM3333894
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: SAMPLE 130
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM3333895

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              SAMPLE 131

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 131 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • SAMPLE 131 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 131 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • SAMPLE 131 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM3333895
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: SAMPLE 131
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: None; ishak fibrosis stage: 1; lobular inflammation: None; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM3333896

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    SAMPLE 132

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 132 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SAMPLE 132 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 132 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SAMPLE 132 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: Mild; portal inflammation: Mild
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM3333896
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: SAMPLE 132
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: Mild; portal inflammation: Mild

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM3333897

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          SAMPLE 133

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 133 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SAMPLE 133 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 133 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SAMPLE 133 Screening Visit_Cluster 3 tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobul...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM3333897
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: SAMPLE 133
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Screening Visit_Cluster 3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Liver Biopsy; histological clusters: Cluster 3; interface activity: None; perivenular fibrosis: Mild; ishak fibrosis stage: 0; lobular inflammation: None; portal inflammation: None

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Excluded samples (0)

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                No excluded samples.