GSE128682

Transcriptional signatures that define Ulcerative Colitis in remission

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

28 case / 16 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

Background: This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was investigated by applying the next-generation technology RNA-Seq. Methods: Mucosal biopsies from patients in remission (n = 14), patients with active UC (n = 14), and healthy control patients (n = 16) underwent whole-transcriptome RNA-Seq. Principal component analysis, cell deconvolution methods, gene profile enrichment, and pathway enrichment methods were applied to define a specific transcriptional signature of UC in remission. Results: Analyses revealed specific transcriptional signatures for UC in remission with increased expression of genes involved in O-glycosylation (MUC17, MUC3A, MUC5AC, MUC12, SPON1, B3GNT3), ephrin-mediated repulsion of cells (EFNB2E, EFNA3, EPHA10, EPHA1), GAP junction trafficking (TUBA1C, TUBA4A, TUBB4B, GJB3, CLTB), and decreased expression of several toll-like receptors (TLR1, TLR3, TLR5, TLR6). Conclusions: This study reveals specific transcriptional signatures for remission. Partial restoration and improvement of homeostasis in the epithelial mucus layer and revival of immunological functions were observed. A clear role for bacterial gut flora composition can be implied. The results can be useful for the development of treatment strategies for UC in remission and may be useful targets for further investigations aiming to predict the outcome of UC in the future.

Overall design

Mucosal biopsies from UC patients in remission (n=14), UC patients (n=14), and healthy controls (n=16) underwent RNA-Seq. Principal component analyse (PCA), cell deconvolution methods and diverse statistical methods were applied to obtain and characterize a dataset of significantly differentially expressed gens (DEGs) during UC remission. ** Raw data not provided due to patient privacy concerns. **

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
44 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

3 linked publications 3 DOIs

Primary publication

  1. Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis. Functional & integrative genomics, 2023
  2. DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies. Scientific reports, 2024
  3. Transcriptional Signatures That Define Ulcerative Colitis in Remission. Inflammatory bowel diseases, 2021
Available

Metadata Quality Components

Analysis Readiness

Ready after review
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

  • Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
  • Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Standard analyst review

Proceed only after the analyst confirms grouping, exclusions, and source files.

By Siftome standards, no expert review was triggered.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Disease context Ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Remission 28 samples
  • Likely control group Healthy control 16 samples

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Biopsy. Comparison suitability: 0%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Interpreted disease metadata: Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 3 publications; 3 DOIs available: PMID 32322884, PMID 37199828, PMID 38514698.
  • Publication context: Transcriptional Signatures That Define Ulcerative Colitis in Remission.. Inflammatory bowel diseases, 2021. PMID 32322884. DOI 10.1093/ibd/izaa075.
  • Publication context: Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis.. Functional & integrative genomics, 2023. PMID 37199828. DOI 10.1007/s10142-023-01099-9.
  • Publication context: DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies.. Scientific reports, 2024. PMID 38514698. DOI 10.1038/s41598-024-57440-0.

Cautions

  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

209 fields

Sample Group Preview

44 rows shown
Show Hide
Study totals: Case 28 | Control 16 | Unassigned 0 | Excluded 0 | Ambiguous 0 44 rows shown
Group Role Accession Title Source / characteristics Reason
Remission Case GSM3682471 Remission sample 1 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682472 Remission sample 2 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682473 Remission sample 3 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682474 Remission sample 4 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682475 Remission sample 5 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682476 Remission sample 6 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682477 Remission sample 7 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682478 Remission sample 8 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682479 Remission sample 9 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682480 Remission sample 10 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682481 Remission sample 11 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682482 Remission sample 12 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682483 Remission sample 13 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Remission Case GSM3682484 Remission sample 14 Colon biopsy Tissue: Mucosal biopsy; Disease status: Remission Explicit characteristic comparison arm detected.
Ulcerative colitis Case GSM3682485 Ulcerative Colitis sample 1 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682486 Ulcerative Colitis sample 2 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682487 Ulcerative Colitis sample 3 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682488 Ulcerative Colitis sample 4 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682489 Ulcerative Colitis sample 5 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682490 Ulcerative Colitis sample 6 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682491 Ulcerative Colitis sample 7 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682492 Ulcerative Colitis sample 8 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682493 Ulcerative Colitis sample 9 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682494 Ulcerative Colitis sample 10 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682495 Ulcerative Colitis sample 11 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682496 Ulcerative Colitis sample 12 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682497 Ulcerative Colitis sample 13 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Ulcerative colitis Case GSM3682498 Ulcerative Colitis sample 14 Colon biopsy Tissue: Mucosal biopsy; Disease status: Ulcerative colitis Case marker detected.
Healthy control Control GSM3682455 Normal sample 1 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682456 Normal sample 2 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682457 Normal sample 3 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682458 Normal sample 4 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682459 Normal sample 5 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682460 Normal sample 6 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682461 Normal sample 7 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682462 Normal sample 8 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682463 Normal sample 9 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682464 Normal sample 10 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682465 Normal sample 11 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682466 Normal sample 12 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682467 Normal sample 13 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682468 Normal sample 14 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682469 Normal sample 15 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.
Healthy control Control GSM3682470 Normal sample 16 Colon biopsy Tissue: Mucosal biopsy; Disease status: Healthy Sample-local control marker detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.