GSE137344

Ileum Transcriptomic Profiling in Inflammatory Bowel Disease

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

157 case / 37 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

We report ileum gene expression of 37 controls and 158 patients with either Crohn's disease (n=112), ulcerative colitis (n=44), unclassifed IBD (1), or IBS (1). We contrast gene expression in African American (n=104) versus white (n=25) CD and UC patients.

Overall design

Biopsies of the ileum were obtained from IBD patients. Transcriptome profiling was performed with RNA-Seq.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
195 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

2 linked publications 2 DOIs

Primary publication

  1. African Ancestry Proportion Influences Ileal Gene Expression in Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology, 2020

Related publications

  1. Identifying inflammatory bowel disease subtypes: a comprehensive exploration of transcriptomic data and machine learning-based approaches. Therapeutic advances in gastroenterology, 2025
Available

Metadata Quality Components

Analysis Readiness

Review before analysis
90% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

8/15 pts

A small number of samples remain unassigned.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • 1 samples are still unassigned.

Next Steps

  • Resolve unassigned or review-needed samples in the grouping table.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Needs review

0 review-needed samples and 1 unassigned samples remain.

Resolve ambiguous and unassigned samples before finalizing the contrast.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

One or more samples are unassigned and need manual grouping decisions.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Disease context Crohn's disease, inflammatory bowel disease, ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Ulcerative colitis 157 samples
  • Likely control group Control 37 samples

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Tissue. Comparison suitability: 0%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Interpreted disease metadata: Crohn's disease, Inflammatory bowel disease, Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 2 publications; 2 DOIs available: PMID 32058087, PMID 40808866.
  • Publication context: African Ancestry Proportion Influences Ileal Gene Expression in Inflammatory Bowel Disease.. Cellular and molecular gastroenterology and hepatology, 2020. PMID 32058087. DOI 10.1016/j.jcmgh.2020.02.001.
  • Publication context: Identifying inflammatory bowel disease subtypes: a comprehensive exploration of transcriptomic data and machine learning-based approaches.. Therapeutic advances in gastroenterology, 2025. PMID 40808866. DOI 10.1177/17562848251362391.

Cautions

  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

showing 500 of 553 fields

Sample Group Preview

showing 88 of 195 preview rows
Show Hide
Study totals: Case 157 | Control 37 | Unassigned 1 | Excluded 0 | Ambiguous 0 showing 88 of 195 preview rows
Group Role Accession Title Source / characteristics Reason
Ulcerative colitis Case GSM4075845 Sample002 Ulcerative Colitis_Ileum Gender: Male; Age at diagnosis: 13; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075846 Sample003 Ulcerative Colitis_Ileum Gender: Female; Age at diagnosis: 13; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075848 Sample005 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 12; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075849 Sample006 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075851 Sample008 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 10; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075852 Sample009 Ulcerative Colitis_Ileum Gender: Female; Age at diagnosis: 8; Ancestry: White; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Inflammatory bowel disease Case GSM4075853 Sample010 Unclassified IBD_Ileum Gender: Male; Age at diagnosis: 13; Ancestry: White; Diagnosis: Unclassified IBD; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075854 Sample011 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 13; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075855 Sample012 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 12; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075856 Sample013 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 5; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075857 Sample014 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 17; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075858 Sample015 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075859 Sample016 Ulcerative Colitis_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075860 Sample017 Ulcerative Colitis_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075861 Sample018 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075863 Sample020 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 18; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075864 Sample021 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 17; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075865 Sample022 Ulcerative Colitis_Ileum Gender: Female; Age at diagnosis: 13; Ancestry: White; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075866 Sample023 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 10; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075867 Sample024 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 9; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075868 Sample025 Ulcerative Colitis_Ileum Gender: Male; Age at diagnosis: 18; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075869 Sample026 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 13; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075871 Sample028 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075873 Sample030 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 8; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075874 Sample031 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 12; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075876 Sample033 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 9; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075877 Sample034 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 13; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075878 Sample035 Ulcerative Colitis_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075879 Sample036 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075880 Sample037 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075882 Sample039 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075883 Sample040 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075884 Sample041 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 11; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075885 Sample042 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 13; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075887 Sample044 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 8; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075888 Sample045 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075889 Sample046 Ulcerative Colitis_Ileum Gender: Female; Age at diagnosis: 16; Ancestry: MULT; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075890 Sample047 Ulcerative Colitis_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075891 Sample048 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075892 Sample049 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 12; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075893 Sample050 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 16; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075894 Sample051 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 12; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075896 Sample053 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075897 Sample054 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 11; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075898 Sample055 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075899 Sample056 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 16; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075900 Sample057 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 17; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075901 Sample058 Crohn's Disease_Ileum Gender: Female; Age at diagnosis: 10; Ancestry: White; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
Ulcerative colitis Case GSM4075902 Sample059 Ulcerative Colitis_Ileum Gender: Female; Age at diagnosis: 7; Ancestry: White; Diagnosis: Ulcerative Colitis; Tissue: Ileum Case marker detected.
Crohn's disease Case GSM4075905 Sample062 Crohn's Disease_Ileum Gender: Male; Age at diagnosis: 10; Ancestry: African American; Diagnosis: Crohn's Disease; Tissue: Ileum Case marker detected.
107 additional case samples are hidden from this preview.
Control Control GSM4075844 Sample001 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075847 Sample004 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: Hispanic; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075850 Sample007 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075862 Sample019 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: Hispanic; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075870 Sample027 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075872 Sample029 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075881 Sample038 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075886 Sample043 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075895 Sample052 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075903 Sample060 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075904 Sample061 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075906 Sample063 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075907 Sample064 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075909 Sample066 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075912 Sample069 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: Asian; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075916 Sample073 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: Multiracial; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075918 Sample075 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075921 Sample078 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075926 Sample083 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075928 Sample085 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075929 Sample086 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075930 Sample087 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: Asian; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075956 Sample113 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075965 Sample122 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075967 Sample124 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075968 Sample125 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075979 Sample136 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4075984 Sample141 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076002 Sample159 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076009 Sample166 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076017 Sample174 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076018 Sample175 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076019 Sample176 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076021 Sample178 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076024 Sample181 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076025 Sample182 Control_Ileum Gender: Female; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Control Control GSM4076028 Sample185 Control_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: African American; Diagnosis: Control; Tissue: Ileum Sample-local control marker detected.
Unassigned Unassigned GSM4075875 Sample032 IBS_Ileum Gender: Male; Age at diagnosis: NA; Ancestry: White; Diagnosis: IBS; Tissue: Ileum No explicit case or control marker detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.