GSE142049

Transcriptional data of inflamatory arthritis B cells

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

43 case / 71 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

With a focus on rheumatoid arthritis (RA), we sought new insight into genetic mechanisms of adaptive immune dysregulation to help prioritise molecular pathways for targeting in this and related immune pathologies. Whole genome methylation and transcriptional data from isolated CD4+ T cells and B cells of >100 genotyped and phenotyped inflammatory arthritis patients, all of whom were naïve to immunomodulatory treatments, were obtained. Analysis integrated these comprehensive data with GWAS findings across IMDs and other publically available resources.

Overall design

Suspected inflammatory arthritis patients of Northern European ancestry were recruited prior to treatment with immunomodulatory drugs. RA patients were classified using current, internationally accepted criteria, and matched with disease controls in respect of demographic and clinical characteristics. CD19+ B cells were isolated from fresh peripheral blood using magnetic bead-based positive selection, with isolation of paired, high-integrity RNA and DNA using the AllPrep DNA/RNA Mini Kit (Qiagen, UK). The majority of samples are from GSE100648.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
114 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

1 linked publication 1 DOI

Primary publication

  1. Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci. The Journal of allergy and clinical immunology, 2020
Available

Metadata Quality Components

Analysis Readiness

Ready after review
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

  • Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
  • Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Lupus erythematosus, rheumatoid arthritis Disease context came from Normalization rules.
  • Likely case group Rheumatoid arthritis 43 samples
  • Likely control group Control 71 samples

Intent Interpretation

  • Downgrade or exclusion reason Downgraded for tissue search because it is a biofluid cohort. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Biofluid. Comparison suitability: 0%.
  • Interpreted disease metadata: Lupus erythematosus, Rheumatoid arthritis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 1 publication; 1 DOI available: PMID 31945409.
  • Publication context: Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.. The Journal of allergy and clinical immunology, 2020. PMID 31945409. DOI 10.1016/j.jaci.2019.12.910.

Cautions

  • Downgraded for tissue search because it is a biofluid cohort.
  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Blood, plasma, or serum cohort downgraded because this ranking targets tissue tumor-vs-normal comparisons.
  • Non-RNA-seq assay context downgraded for RNA-seq dataset discovery.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because the assay context is not primary RNA-seq expression profiling.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

391 fields

Sample Group Preview

showing 93 of 114 preview rows
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Study totals: Case 43 | Control 71 | Unassigned 0 | Excluded 0 | Ambiguous 0 showing 93 of 114 preview rows
Group Role Accession Title Source / characteristics Reason
Rheumatoid arthritis Case GSM4218231 B cells Newcastle Early Arthritis Clinic number 2368 Rheumatoid Arthritis B cells Patient: 2368; Gender: F; Age: 61; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218235 B cells Newcastle Early Arthritis Clinic number 1010 Rheumatoid Arthritis B cells Patient: 1010; Gender: F; Age: 50; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218237 B cells Newcastle Early Arthritis Clinic number 926 Rheumatoid Arthritis B cells Patient: 926; Gender: M; Age: 61; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218238 B cells Newcastle Early Arthritis Clinic number 948 Rheumatoid Arthritis B cells Patient: 948; Gender: F; Age: 53; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218244 B cells Newcastle Early Arthritis Clinic number 2029 Rheumatoid Arthritis B cells Patient: 2029; Gender: M; Age: 59; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218246 B cells Newcastle Early Arthritis Clinic number 2030 Rheumatoid Arthritis B cells Patient: 2030; Gender: M; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218247 B cells Newcastle Early Arthritis Clinic number 2045 Rheumatoid Arthritis B cells Patient: 2045; Gender: M; Age: 55; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218248 B cells Newcastle Early Arthritis Clinic number 2231 Rheumatoid Arthritis B cells Patient: 2231; Gender: F; Age: 56; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218254 B cells Newcastle Early Arthritis Clinic number 1072 Rheumatoid Arthritis B cells Patient: 1072; Gender: F; Age: 50; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218257 B cells Newcastle Early Arthritis Clinic number 1083 Rheumatoid Arthritis B cells Patient: 1083; Gender: F; Age: 63; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218261 B cells Newcastle Early Arthritis Clinic number 2072 Rheumatoid Arthritis B cells Patient: 2072; Gender: F; Age: 58; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218265 B cells Newcastle Early Arthritis Clinic number 992 Rheumatoid Arthritis B cells Patient: 992; Gender: F; Age: 60; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218267 B cells Newcastle Early Arthritis Clinic number 995 Rheumatoid Arthritis B cells Patient: 995; Gender: F; Age: 73; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218270 B cells Newcastle Early Arthritis Clinic number 2010 Rheumatoid Arthritis B cells Patient: 2010; Gender: F; Age: 46; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218273 B cells Newcastle Early Arthritis Clinic number 1094 Rheumatoid Arthritis B cells Patient: 1094; Gender: M; Age: 61; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Reactive Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218276 B cells Newcastle Early Arthritis Clinic number 882 Rheumatoid Arthritis B cells Patient: 882; Gender: F; Age: 27; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218277 B cells Newcastle Early Arthritis Clinic number 932 Rheumatoid Arthritis B cells Patient: 932; Gender: F; Age: 73; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218283 B cells Newcastle Early Arthritis Clinic number 2510 Rheumatoid Arthritis B cells Patient: 2510; Gender: F; Age: 51; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218287 B cells Newcastle Early Arthritis Clinic number 2311 Rheumatoid Arthritis B cells Patient: 2311; Gender: F; Age: 40; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218289 B cells Newcastle Early Arthritis Clinic number 2348 Rheumatoid Arthritis B cells Patient: 2348; Gender: M; Age: 62; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218291 B cells Newcastle Early Arthritis Clinic number 2345 Rheumatoid Arthritis B cells Patient: 2345; Gender: F; Age: 82; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218293 B cells Newcastle Early Arthritis Clinic number 930 Rheumatoid Arthritis B cells Patient: 930; Gender: F; Age: 69; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218294 B cells Newcastle Early Arthritis Clinic number 957 Rheumatoid Arthritis B cells Patient: 957; Gender: M; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218297 B cells Newcastle Early Arthritis Clinic number 2759 Rheumatoid Arthritis B cells Patient: 2759; Gender: F; Age: 68; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218298 B cells Newcastle Early Arthritis Clinic number 2767 Rheumatoid Arthritis B cells Patient: 2767; Gender: F; Age: 43; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218299 B cells Newcastle Early Arthritis Clinic number 2166 Rheumatoid Arthritis B cells Patient: 2166; Gender: F; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218301 B cells Newcastle Early Arthritis Clinic number 2203 Rheumatoid Arthritis B cells Patient: 2203; Gender: F; Age: 50; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218305 B cells Newcastle Early Arthritis Clinic number 2133 Rheumatoid Arthritis B cells Patient: 2133; Gender: F; Age: 70; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218306 B cells Newcastle Early Arthritis Clinic number 938 Rheumatoid Arthritis B cells Patient: 938; Gender: M; Age: 74; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218309 B cells Newcastle Early Arthritis Clinic number 1000 Rheumatoid Arthritis B cells Patient: 1000; Gender: F; Age: 74; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218312 B cells Newcastle Early Arthritis Clinic number 1003 Rheumatoid Arthritis B cells Patient: 1003; Gender: M; Age: 51; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218314 B cells Newcastle Early Arthritis Clinic number 1005 Rheumatoid Arthritis B cells Patient: 1005; Gender: F; Age: 69; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218315 B cells Newcastle Early Arthritis Clinic number 892 Rheumatoid Arthritis B cells Patient: 892; Gender: M; Age: 71; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218317 B cells Newcastle Early Arthritis Clinic number 915 Rheumatoid Arthritis B cells Patient: 915; Gender: F; Age: 39; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218318 B cells Newcastle Early Arthritis Clinic number 944 Rheumatoid Arthritis B cells Patient: 944; Gender: F; Age: 51; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218320 B cells Newcastle Early Arthritis Clinic number 974 Rheumatoid Arthritis B cells Patient: 974; Gender: F; Age: 69; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218323 B cells Newcastle Early Arthritis Clinic number 996 Rheumatoid Arthritis B cells Patient: 996; Gender: F; Age: 53; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218326 B cells Newcastle Early Arthritis Clinic number 827 Rheumatoid Arthritis B cells Patient: 827; Gender: F; Age: 50; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218330 B cells Newcastle Early Arthritis Clinic number 975 Rheumatoid Arthritis B cells Patient: 975; Gender: F; Age: 54; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218331 B cells Newcastle Early Arthritis Clinic number 946 Rheumatoid Arthritis B cells Patient: 946; Gender: M; Age: 43; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218332 B cells Newcastle Early Arthritis Clinic number 978 Rheumatoid Arthritis B cells Patient: 978; Gender: F; Age: 62; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218334 B cells Newcastle Early Arthritis Clinic number 1032 Rheumatoid Arthritis B cells Patient: 1032; Gender: F; Age: 68; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Rheumatoid arthritis Case GSM4218342 B cells Newcastle Early Arthritis Clinic number 2090 Rheumatoid Arthritis B cells Patient: 2090; Gender: F; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Rheumatoid Arthritis; Working_diagnosis: Rheumatoid Arthritis Case marker detected.
Control Control GSM4218229 B cells Newcastle Early Arthritis Clinic number 2367 Disease control B cells Patient: 2367; Gender: M; Age: 82; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Spondylo-Arthropathy; Working_diagnosis: Undifferentiated Spondylo-Arthropathy Sample-local control marker detected.
Control Control GSM4218230 B cells Newcastle Early Arthritis Clinic number 2390 Disease control B cells Patient: 2390; Gender: M; Age: 29; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Other Inflammatory Arthritis; Working_diagnosis: Other Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218232 B cells Newcastle Early Arthritis Clinic number 2437 Disease control B cells Patient: 2437; Gender: M; Age: 56; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218233 B cells Newcastle Early Arthritis Clinic number 2439 Disease control B cells Patient: 2439; Gender: F; Age: 55; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218234 B cells Newcastle Early Arthritis Clinic number 2379 Disease control B cells Patient: 2379; Gender: M; Age: 72; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218236 B cells Newcastle Early Arthritis Clinic number 841 Disease control B cells Patient: 841; Gender: M; Age: 22; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218239 B cells Newcastle Early Arthritis Clinic number 898 Disease control B cells Patient: 898; Gender: F; Age: 54; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218240 B cells Newcastle Early Arthritis Clinic number 980 Disease control B cells Patient: 980; Gender: F; Age: 20; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218241 B cells Newcastle Early Arthritis Clinic number 2145 Disease control B cells Patient: 2145; Gender: F; Age: 49; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Enteropathic Arthritis; Working_diagnosis: Enteropathic Arthritis Sample-local control marker detected.
Control Control GSM4218242 B cells Newcastle Early Arthritis Clinic number 2036 Disease control B cells Patient: 2036; Gender: M; Age: 61; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Osteoarthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218243 B cells Newcastle Early Arthritis Clinic number 2040 Disease control B cells Patient: 2040; Gender: F; Age: 53; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Osteoarthritis Sample-local control marker detected.
Control Control GSM4218245 B cells Newcastle Early Arthritis Clinic number 2044 Disease control B cells Patient: 2044; Gender: F; Age: 56; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Psoriatic Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218249 B cells Newcastle Early Arthritis Clinic number 2257 Disease control B cells Patient: 2257; Gender: F; Age: 35; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218250 B cells Newcastle Early Arthritis Clinic number 2233 Disease control B cells Patient: 2233; Gender: F; Age: 58; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Other Inflammatory Arthritis; Working_diagnosis: Other Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218251 B cells Newcastle Early Arthritis Clinic number 2261 Disease control B cells Patient: 2261; Gender: M; Age: 69; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Crystal Arthritis Sample-local control marker detected.
Control Control GSM4218252 B cells Newcastle Early Arthritis Clinic number 1070 Disease control B cells Patient: 1070; Gender: F; Age: 46; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Psoriatic Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218253 B cells Newcastle Early Arthritis Clinic number 1054 Disease control B cells Patient: 1054; Gender: F; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Osteoarthritis Sample-local control marker detected.
Control Control GSM4218255 B cells Newcastle Early Arthritis Clinic number 1076 Disease control B cells Patient: 1076; Gender: F; Age: 66; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Reactive Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218256 B cells Newcastle Early Arthritis Clinic number 1080 Disease control B cells Patient: 1080; Gender: F; Age: 52; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Psoriatic Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218258 B cells Newcastle Early Arthritis Clinic number 2047 Disease control B cells Patient: 2047; Gender: M; Age: 51; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Psoriatic Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218259 B cells Newcastle Early Arthritis Clinic number 2052 Disease control B cells Patient: 2052; Gender: F; Age: 50; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Non-Inflammatory Sample-local control marker detected.
Control Control GSM4218260 B cells Newcastle Early Arthritis Clinic number 2054 Disease control B cells Patient: 2054; Gender: M; Age: 66; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Crystal Arthritis Sample-local control marker detected.
Control Control GSM4218262 B cells Newcastle Early Arthritis Clinic number 2062 Disease control B cells Patient: 2062; Gender: M; Age: 60; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Crystal Arthritis Sample-local control marker detected.
Control Control GSM4218263 B cells Newcastle Early Arthritis Clinic number 2078 Disease control B cells Patient: 2078; Gender: M; Age: 92; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Crystal Arthritis Sample-local control marker detected.
Control Control GSM4218264 B cells Newcastle Early Arthritis Clinic number 962 Disease control B cells Patient: 962; Gender: M; Age: 65; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Psoriatic Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218266 B cells Newcastle Early Arthritis Clinic number 965 Disease control B cells Patient: 965; Gender: M; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Osteoarthritis Sample-local control marker detected.
Control Control GSM4218268 B cells Newcastle Early Arthritis Clinic number 1085 Disease control B cells Patient: 1085; Gender: F; Age: 43; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218269 B cells Newcastle Early Arthritis Clinic number 1087 Disease control B cells Patient: 1087; Gender: M; Age: 55; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Crystal Arthritis Sample-local control marker detected.
Control Control GSM4218271 B cells Newcastle Early Arthritis Clinic number 1088 Disease control B cells Patient: 1088; Gender: F; Age: 54; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218272 B cells Newcastle Early Arthritis Clinic number 2012 Disease control B cells Patient: 2012; Gender: F; Age: 63; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Reactive Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218274 B cells Newcastle Early Arthritis Clinic number 905 Disease control B cells Patient: 905; Gender: F; Age: 56; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Spondylo-Arthropathy; Working_diagnosis: Undifferentiated Spondylo-Arthropathy Sample-local control marker detected.
Control Control GSM4218275 B cells Newcastle Early Arthritis Clinic number 845 Disease control B cells Patient: 845; Gender: F; Age: 67; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Other Inflammatory Arthritis; Working_diagnosis: Other Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218278 B cells Newcastle Early Arthritis Clinic number 2519 Disease control B cells Patient: 2519; Gender: F; Age: 32; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Undifferentiated Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218279 B cells Newcastle Early Arthritis Clinic number 2493 Disease control B cells Patient: 2493; Gender: F; Age: 54; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Reactive Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218280 B cells Newcastle Early Arthritis Clinic number 2506 Disease control B cells Patient: 2506; Gender: M; Age: 61; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Undifferentiated Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218281 B cells Newcastle Early Arthritis Clinic number 2507 Disease control B cells Patient: 2507; Gender: F; Age: 22; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218282 B cells Newcastle Early Arthritis Clinic number 2549 Disease control B cells Patient: 2549; Gender: F; Age: 52; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Undifferentiated Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218284 B cells Newcastle Early Arthritis Clinic number 2511 Disease control B cells Patient: 2511; Gender: F; Age: 53; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Undifferentiated Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218285 B cells Newcastle Early Arthritis Clinic number 2264 Disease control B cells Patient: 2264; Gender: F; Age: 70; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Enteropathic Arthritis; Working_diagnosis: Enteropathic Arthritis Sample-local control marker detected.
Control Control GSM4218286 B cells Newcastle Early Arthritis Clinic number 2281 Disease control B cells Patient: 2281; Gender: F; Age: 56; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Other Inflammatory Arthritis; Working_diagnosis: Other Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218288 B cells Newcastle Early Arthritis Clinic number 2305 Disease control B cells Patient: 2305; Gender: F; Age: 59; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Lupus/Other CTD-Associated Sample-local control marker detected.
Control Control GSM4218290 B cells Newcastle Early Arthritis Clinic number 2330 Disease control B cells Patient: 2330; Gender: F; Age: 32; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Non-Inflammatory; Working_diagnosis: Non-Inflammatory Sample-local control marker detected.
Control Control GSM4218292 B cells Newcastle Early Arthritis Clinic number 954 Disease control B cells Patient: 954; Gender: F; Age: 45; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218295 B cells Newcastle Early Arthritis Clinic number 879 Disease control B cells Patient: 879; Gender: M; Age: 79; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Reactive Arthritis Sample-local control marker detected.
Control Control GSM4218296 B cells Newcastle Early Arthritis Clinic number 1037 Disease control B cells Patient: 1037; Gender: M; Age: 65; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Crystal Arthritis; Working_diagnosis: Crystal Arthritis Sample-local control marker detected.
Control Control GSM4218300 B cells Newcastle Early Arthritis Clinic number 2476 Disease control B cells Patient: 2476; Gender: F; Age: 81; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Undifferentiated Inflammatory Arthritis Sample-local control marker detected.
Control Control GSM4218302 B cells Newcastle Early Arthritis Clinic number 2197 Disease control B cells Patient: 2197; Gender: F; Age: 57; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Non-Inflammatory; Working_diagnosis: Non-Inflammatory Sample-local control marker detected.
Control Control GSM4218303 B cells Newcastle Early Arthritis Clinic number 2086 Disease control B cells Patient: 2086; Gender: F; Age: 45; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Non-Inflammatory; Working_diagnosis: Non-Inflammatory Sample-local control marker detected.
Control Control GSM4218304 B cells Newcastle Early Arthritis Clinic number 2087 Disease control B cells Patient: 2087; Gender: F; Age: 47; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Psoriatic Arthritis; Working_diagnosis: Psoriatic Arthritis Sample-local control marker detected.
Control Control GSM4218307 B cells Newcastle Early Arthritis Clinic number 891 Disease control B cells Patient: 891; Gender: F; Age: 26; Tissue: Peripheral blood; Cell type: CD19+ B cells; First_diagnosis: Undifferentiated Inflammatory Arthritis; Working_diagnosis: Other Inflammatory Arthritis Sample-local control marker detected.
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