Matching samples

GSE16879 · Mucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment

Download matching samples CSV
Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

121 case / 12 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

The CSV contains only the confirmed cases and controls below. Excluded and uncertain samples are shown for review and are not exported.

These are sample eligibility decisions from the current indexed metadata. Study-level search filters and minimum sample counts do not establish expression quality or analysis readiness.

Included samples (0)

No samples meet the selected requirements. The CSV contains its column headers only.

Uncertain samples (133)

These samples need more evidence before they can be counted. This includes samples without a confirmed case/control role.

GSM364627

Uncertain

CO1

Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

Requirements and decision evidence
  • organism: Homo sapiens — Insufficient evidence
    • The required value is not reported.
    • assay type: bulk RNA-seq — Insufficient evidence
      • The required value is not reported.
      • specimen category: Tissue or biopsy — Insufficient evidence
        • The required value is not reported.
        • CO1 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
        • CO1 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
        • Supported by the indexed evidence.
        • specimen category excludes: Biofluid — Insufficient evidence
          • The required value is not reported.
          • CO1 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
          • CO1 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
        Source metadata
        Source name
        Colonic mucosal biopsy from control individual
        Characteristics
        tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
        Description
        Not reported
        Indexed organism evidence
        INFERRED · PARENT_INHERITED: Not reported
        Indexed assay evidence
        INFERRED · PARENT_INHERITED: Not reported
        Source
        GEO
        Original indexed metadata
        sample_accession: GSM364627
        sample_title: CO1
        source_name: Colonic mucosal biopsy from control individual
        characteristics: tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

        GSM364628

        Uncertain

        CO2

        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

        Requirements and decision evidence
        • organism: Homo sapiens — Insufficient evidence
          • The required value is not reported.
          • assay type: bulk RNA-seq — Insufficient evidence
            • The required value is not reported.
            • specimen category: Tissue or biopsy — Insufficient evidence
              • The required value is not reported.
              • CO2 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
              • CO2 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
              • Supported by the indexed evidence.
              • specimen category excludes: Biofluid — Insufficient evidence
                • The required value is not reported.
                • CO2 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                • CO2 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
              Source metadata
              Source name
              Colonic mucosal biopsy from control individual
              Characteristics
              tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
              Description
              Not reported
              Indexed organism evidence
              INFERRED · PARENT_INHERITED: Not reported
              Indexed assay evidence
              INFERRED · PARENT_INHERITED: Not reported
              Source
              GEO
              Original indexed metadata
              sample_accession: GSM364628
              sample_title: CO2
              source_name: Colonic mucosal biopsy from control individual
              characteristics: tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

              GSM364629

              Uncertain

              CO3

              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

              Requirements and decision evidence
              • organism: Homo sapiens — Insufficient evidence
                • The required value is not reported.
                • assay type: bulk RNA-seq — Insufficient evidence
                  • The required value is not reported.
                  • specimen category: Tissue or biopsy — Insufficient evidence
                    • The required value is not reported.
                    • CO3 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                    • CO3 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                    • Supported by the indexed evidence.
                    • specimen category excludes: Biofluid — Insufficient evidence
                      • The required value is not reported.
                      • CO3 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                      • CO3 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                    Source metadata
                    Source name
                    Colonic mucosal biopsy from control individual
                    Characteristics
                    tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                    Description
                    Not reported
                    Indexed organism evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Indexed assay evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Source
                    GEO
                    Original indexed metadata
                    sample_accession: GSM364629
                    sample_title: CO3
                    source_name: Colonic mucosal biopsy from control individual
                    characteristics: tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                    GSM364630

                    Uncertain

                    CO4

                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                    Requirements and decision evidence
                    • organism: Homo sapiens — Insufficient evidence
                      • The required value is not reported.
                      • assay type: bulk RNA-seq — Insufficient evidence
                        • The required value is not reported.
                        • specimen category: Tissue or biopsy — Insufficient evidence
                          • The required value is not reported.
                          • CO4 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                          • CO4 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                          • Supported by the indexed evidence.
                          • specimen category excludes: Biofluid — Insufficient evidence
                            • The required value is not reported.
                            • CO4 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                            • CO4 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                          Source metadata
                          Source name
                          Colonic mucosal biopsy from control individual
                          Characteristics
                          tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                          Description
                          Not reported
                          Indexed organism evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Indexed assay evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Source
                          GEO
                          Original indexed metadata
                          sample_accession: GSM364630
                          sample_title: CO4
                          source_name: Colonic mucosal biopsy from control individual
                          characteristics: tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                          GSM364631

                          Uncertain

                          CO5

                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                          Requirements and decision evidence
                          • organism: Homo sapiens — Insufficient evidence
                            • The required value is not reported.
                            • assay type: bulk RNA-seq — Insufficient evidence
                              • The required value is not reported.
                              • specimen category: Tissue or biopsy — Insufficient evidence
                                • The required value is not reported.
                                • CO5 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                • CO5 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                • Supported by the indexed evidence.
                                • specimen category excludes: Biofluid — Insufficient evidence
                                  • The required value is not reported.
                                  • CO5 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                  • CO5 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                Source metadata
                                Source name
                                Colonic mucosal biopsy from control individual
                                Characteristics
                                tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                Description
                                Not reported
                                Indexed organism evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Indexed assay evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Source
                                GEO
                                Original indexed metadata
                                sample_accession: GSM364631
                                sample_title: CO5
                                source_name: Colonic mucosal biopsy from control individual
                                characteristics: tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                GSM364632

                                Uncertain

                                CO6

                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                Requirements and decision evidence
                                • organism: Homo sapiens — Insufficient evidence
                                  • The required value is not reported.
                                  • assay type: bulk RNA-seq — Insufficient evidence
                                    • The required value is not reported.
                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                      • The required value is not reported.
                                      • CO6 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                      • CO6 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                      • Supported by the indexed evidence.
                                      • specimen category excludes: Biofluid — Insufficient evidence
                                        • The required value is not reported.
                                        • CO6 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                        • CO6 Colonic mucosal biopsy from control individual tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not appli...
                                      Source metadata
                                      Source name
                                      Colonic mucosal biopsy from control individual
                                      Characteristics
                                      tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                      Description
                                      Not reported
                                      Indexed organism evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Indexed assay evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Source
                                      GEO
                                      Original indexed metadata
                                      sample_accession: GSM364632
                                      sample_title: CO6
                                      source_name: Colonic mucosal biopsy from control individual
                                      characteristics: tissue: Colon; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                      GSM364633

                                      Uncertain

                                      UCR1_beforeT

                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                      Requirements and decision evidence
                                      • organism: Homo sapiens — Insufficient evidence
                                        • The required value is not reported.
                                        • assay type: bulk RNA-seq — Insufficient evidence
                                          • The required value is not reported.
                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                            • The required value is not reported.
                                            • UCR1_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                            • UCR1_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                            • Supported by the indexed evidence.
                                            • specimen category excludes: Biofluid — Insufficient evidence
                                              • The required value is not reported.
                                              • UCR1_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                              • UCR1_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                            Source metadata
                                            Source name
                                            Colonic mucosal biopsy from UC responder before first infliximab treatment
                                            Characteristics
                                            tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                            Description
                                            Not reported
                                            Indexed organism evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Indexed assay evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Source
                                            GEO
                                            Original indexed metadata
                                            sample_accession: GSM364633
                                            sample_title: UCR1_beforeT
                                            source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                            characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                            GSM364634

                                            Uncertain

                                            UCR2_beforeT

                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                            Requirements and decision evidence
                                            • organism: Homo sapiens — Insufficient evidence
                                              • The required value is not reported.
                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                • The required value is not reported.
                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                  • The required value is not reported.
                                                  • UCR2_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                  • UCR2_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                  • Supported by the indexed evidence.
                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                    • The required value is not reported.
                                                    • UCR2_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                    • UCR2_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                  Source metadata
                                                  Source name
                                                  Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                  Characteristics
                                                  tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                  Description
                                                  Not reported
                                                  Indexed organism evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Indexed assay evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Source
                                                  GEO
                                                  Original indexed metadata
                                                  sample_accession: GSM364634
                                                  sample_title: UCR2_beforeT
                                                  source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                  characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                  GSM364635

                                                  Uncertain

                                                  UCR3_beforeT

                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                  Requirements and decision evidence
                                                  • organism: Homo sapiens — Insufficient evidence
                                                    • The required value is not reported.
                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                      • The required value is not reported.
                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                        • The required value is not reported.
                                                        • UCR3_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                        • UCR3_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                        • Supported by the indexed evidence.
                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                          • The required value is not reported.
                                                          • UCR3_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                          • UCR3_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                        Source metadata
                                                        Source name
                                                        Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                        Characteristics
                                                        tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                        Description
                                                        Not reported
                                                        Indexed organism evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Indexed assay evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Source
                                                        GEO
                                                        Original indexed metadata
                                                        sample_accession: GSM364635
                                                        sample_title: UCR3_beforeT
                                                        source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                        characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                        GSM364636

                                                        Uncertain

                                                        UCR4_beforeT

                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                        Requirements and decision evidence
                                                        • organism: Homo sapiens — Insufficient evidence
                                                          • The required value is not reported.
                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                            • The required value is not reported.
                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                              • The required value is not reported.
                                                              • UCR4_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                              • UCR4_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                              • Supported by the indexed evidence.
                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                • The required value is not reported.
                                                                • UCR4_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                • UCR4_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                              Source metadata
                                                              Source name
                                                              Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                              Characteristics
                                                              tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                              Description
                                                              Not reported
                                                              Indexed organism evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Indexed assay evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Source
                                                              GEO
                                                              Original indexed metadata
                                                              sample_accession: GSM364636
                                                              sample_title: UCR4_beforeT
                                                              source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                              characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                              GSM364637

                                                              Uncertain

                                                              UCR5_beforeT

                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                              Requirements and decision evidence
                                                              • organism: Homo sapiens — Insufficient evidence
                                                                • The required value is not reported.
                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                  • The required value is not reported.
                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                    • The required value is not reported.
                                                                    • UCR5_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                    • UCR5_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                    • Supported by the indexed evidence.
                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • UCR5_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                      • UCR5_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                    Source metadata
                                                                    Source name
                                                                    Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                    Characteristics
                                                                    tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                    Description
                                                                    Not reported
                                                                    Indexed organism evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Indexed assay evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Source
                                                                    GEO
                                                                    Original indexed metadata
                                                                    sample_accession: GSM364637
                                                                    sample_title: UCR5_beforeT
                                                                    source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                    characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                    GSM364638

                                                                    Uncertain

                                                                    UCR6_beforeT

                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                    Requirements and decision evidence
                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                        • The required value is not reported.
                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                          • The required value is not reported.
                                                                          • UCR6_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                          • UCR6_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                          • Supported by the indexed evidence.
                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • UCR6_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                            • UCR6_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                          Source metadata
                                                                          Source name
                                                                          Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                          Characteristics
                                                                          tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                          Description
                                                                          Not reported
                                                                          Indexed organism evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Indexed assay evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Source
                                                                          GEO
                                                                          Original indexed metadata
                                                                          sample_accession: GSM364638
                                                                          sample_title: UCR6_beforeT
                                                                          source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                          characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                          GSM364639

                                                                          Uncertain

                                                                          UCR7_beforeT

                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                          Requirements and decision evidence
                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                              • The required value is not reported.
                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                • The required value is not reported.
                                                                                • UCR7_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                • UCR7_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                • Supported by the indexed evidence.
                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • UCR7_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                  • UCR7_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                Source metadata
                                                                                Source name
                                                                                Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                                Characteristics
                                                                                tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                Description
                                                                                Not reported
                                                                                Indexed organism evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Indexed assay evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Source
                                                                                GEO
                                                                                Original indexed metadata
                                                                                sample_accession: GSM364639
                                                                                sample_title: UCR7_beforeT
                                                                                source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                                characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                GSM364640

                                                                                Uncertain

                                                                                UCR8_beforeT

                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                Requirements and decision evidence
                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                    • The required value is not reported.
                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                      • The required value is not reported.
                                                                                      • UCR8_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                      • UCR8_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                      • Supported by the indexed evidence.
                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • UCR8_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                        • UCR8_beforeT Colonic mucosal biopsy from UC responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab...
                                                                                      Source metadata
                                                                                      Source name
                                                                                      Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                                      Characteristics
                                                                                      tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                      Description
                                                                                      Not reported
                                                                                      Indexed organism evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Indexed assay evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Source
                                                                                      GEO
                                                                                      Original indexed metadata
                                                                                      sample_accession: GSM364640
                                                                                      sample_title: UCR8_beforeT
                                                                                      source_name: Colonic mucosal biopsy from UC responder before first infliximab treatment
                                                                                      characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                      GSM364641

                                                                                      Uncertain

                                                                                      UCNR1_beforeT

                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                      Requirements and decision evidence
                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                          • The required value is not reported.
                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                            • The required value is not reported.
                                                                                            • UCNR1_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                            • UCNR1_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                            • Supported by the indexed evidence.
                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • UCNR1_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                              • UCNR1_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                            Source metadata
                                                                                            Source name
                                                                                            Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                            Characteristics
                                                                                            tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                            Description
                                                                                            Not reported
                                                                                            Indexed organism evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Indexed assay evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Source
                                                                                            GEO
                                                                                            Original indexed metadata
                                                                                            sample_accession: GSM364641
                                                                                            sample_title: UCNR1_beforeT
                                                                                            source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                            characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                            GSM364642

                                                                                            Uncertain

                                                                                            UCNR2_beforeT

                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                            Requirements and decision evidence
                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                • The required value is not reported.
                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                  • The required value is not reported.
                                                                                                  • UCNR2_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                  • UCNR2_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                  • Supported by the indexed evidence.
                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • UCNR2_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                    • UCNR2_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                  Source metadata
                                                                                                  Source name
                                                                                                  Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                  Characteristics
                                                                                                  tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                  Description
                                                                                                  Not reported
                                                                                                  Indexed organism evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Indexed assay evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Source
                                                                                                  GEO
                                                                                                  Original indexed metadata
                                                                                                  sample_accession: GSM364642
                                                                                                  sample_title: UCNR2_beforeT
                                                                                                  source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                  characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                  GSM364643

                                                                                                  Uncertain

                                                                                                  UCNR3_beforeT

                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                  Requirements and decision evidence
                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                      • The required value is not reported.
                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                        • The required value is not reported.
                                                                                                        • UCNR3_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                        • UCNR3_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                        • Supported by the indexed evidence.
                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • UCNR3_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                          • UCNR3_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                        Source metadata
                                                                                                        Source name
                                                                                                        Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                        Characteristics
                                                                                                        tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                        Description
                                                                                                        Not reported
                                                                                                        Indexed organism evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Indexed assay evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Source
                                                                                                        GEO
                                                                                                        Original indexed metadata
                                                                                                        sample_accession: GSM364643
                                                                                                        sample_title: UCNR3_beforeT
                                                                                                        source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                        characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                        GSM364644

                                                                                                        Uncertain

                                                                                                        UCNR4_beforeT

                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                        Requirements and decision evidence
                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                            • The required value is not reported.
                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                              • The required value is not reported.
                                                                                                              • UCNR4_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                              • UCNR4_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                              • Supported by the indexed evidence.
                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • UCNR4_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                • UCNR4_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                              Source metadata
                                                                                                              Source name
                                                                                                              Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                              Characteristics
                                                                                                              tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                              Description
                                                                                                              Not reported
                                                                                                              Indexed organism evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Indexed assay evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Source
                                                                                                              GEO
                                                                                                              Original indexed metadata
                                                                                                              sample_accession: GSM364644
                                                                                                              sample_title: UCNR4_beforeT
                                                                                                              source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                              characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                              GSM364645

                                                                                                              Uncertain

                                                                                                              UCNR5_beforeT

                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                              Requirements and decision evidence
                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                  • The required value is not reported.
                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                    • The required value is not reported.
                                                                                                                    • UCNR5_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                    • UCNR5_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                    • Supported by the indexed evidence.
                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • UCNR5_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                      • UCNR5_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                    Source metadata
                                                                                                                    Source name
                                                                                                                    Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                    Characteristics
                                                                                                                    tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                    Description
                                                                                                                    Not reported
                                                                                                                    Indexed organism evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Indexed assay evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Source
                                                                                                                    GEO
                                                                                                                    Original indexed metadata
                                                                                                                    sample_accession: GSM364645
                                                                                                                    sample_title: UCNR5_beforeT
                                                                                                                    source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                    characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                    GSM364646

                                                                                                                    Uncertain

                                                                                                                    UCNR6_beforeT

                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                    Requirements and decision evidence
                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                        • The required value is not reported.
                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                          • The required value is not reported.
                                                                                                                          • UCNR6_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                          • UCNR6_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                          • Supported by the indexed evidence.
                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • UCNR6_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                            • UCNR6_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                          Source metadata
                                                                                                                          Source name
                                                                                                                          Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                          Characteristics
                                                                                                                          tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                          Description
                                                                                                                          Not reported
                                                                                                                          Indexed organism evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Indexed assay evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Source
                                                                                                                          GEO
                                                                                                                          Original indexed metadata
                                                                                                                          sample_accession: GSM364646
                                                                                                                          sample_title: UCNR6_beforeT
                                                                                                                          source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                          characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                          GSM364647

                                                                                                                          Uncertain

                                                                                                                          UCNR7_beforeT

                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                          Requirements and decision evidence
                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                              • The required value is not reported.
                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                • The required value is not reported.
                                                                                                                                • UCNR7_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                • UCNR7_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • UCNR7_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                  • UCNR7_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                Source metadata
                                                                                                                                Source name
                                                                                                                                Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                Characteristics
                                                                                                                                tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                Description
                                                                                                                                Not reported
                                                                                                                                Indexed organism evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Indexed assay evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Source
                                                                                                                                GEO
                                                                                                                                Original indexed metadata
                                                                                                                                sample_accession: GSM364647
                                                                                                                                sample_title: UCNR7_beforeT
                                                                                                                                source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                GSM364648

                                                                                                                                Uncertain

                                                                                                                                UCNR8_beforeT

                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                Requirements and decision evidence
                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                    • The required value is not reported.
                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                      • The required value is not reported.
                                                                                                                                      • UCNR8_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                      • UCNR8_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • UCNR8_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                        • UCNR8_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                      Source metadata
                                                                                                                                      Source name
                                                                                                                                      Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                      Characteristics
                                                                                                                                      tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                      Description
                                                                                                                                      Not reported
                                                                                                                                      Indexed organism evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Indexed assay evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Source
                                                                                                                                      GEO
                                                                                                                                      Original indexed metadata
                                                                                                                                      sample_accession: GSM364648
                                                                                                                                      sample_title: UCNR8_beforeT
                                                                                                                                      source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                      characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                      GSM364649

                                                                                                                                      Uncertain

                                                                                                                                      UCNR9_beforeT

                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                      Requirements and decision evidence
                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                          • The required value is not reported.
                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                            • The required value is not reported.
                                                                                                                                            • UCNR9_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                            • UCNR9_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • UCNR9_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                              • UCNR9_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflix...
                                                                                                                                            Source metadata
                                                                                                                                            Source name
                                                                                                                                            Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                            Characteristics
                                                                                                                                            tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                            Description
                                                                                                                                            Not reported
                                                                                                                                            Indexed organism evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Indexed assay evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Source
                                                                                                                                            GEO
                                                                                                                                            Original indexed metadata
                                                                                                                                            sample_accession: GSM364649
                                                                                                                                            sample_title: UCNR9_beforeT
                                                                                                                                            source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                            characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                            GSM364650

                                                                                                                                            Uncertain

                                                                                                                                            UCNR10_beforeT

                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                            Requirements and decision evidence
                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                • The required value is not reported.
                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                  • The required value is not reported.
                                                                                                                                                  • UCNR10_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                  • UCNR10_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • UCNR10_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                    • UCNR10_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                  Source metadata
                                                                                                                                                  Source name
                                                                                                                                                  Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                  Characteristics
                                                                                                                                                  tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                  Description
                                                                                                                                                  Not reported
                                                                                                                                                  Indexed organism evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Indexed assay evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Source
                                                                                                                                                  GEO
                                                                                                                                                  Original indexed metadata
                                                                                                                                                  sample_accession: GSM364650
                                                                                                                                                  sample_title: UCNR10_beforeT
                                                                                                                                                  source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                  characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                  GSM364651

                                                                                                                                                  Uncertain

                                                                                                                                                  UCNR11_beforeT

                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                      • The required value is not reported.
                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                        • The required value is not reported.
                                                                                                                                                        • UCNR11_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                        • UCNR11_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                          • The required value is not reported.
                                                                                                                                                          • UCNR11_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                          • UCNR11_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                        Source metadata
                                                                                                                                                        Source name
                                                                                                                                                        Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                        Characteristics
                                                                                                                                                        tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                        Description
                                                                                                                                                        Not reported
                                                                                                                                                        Indexed organism evidence
                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                        Indexed assay evidence
                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                        Source
                                                                                                                                                        GEO
                                                                                                                                                        Original indexed metadata
                                                                                                                                                        sample_accession: GSM364651
                                                                                                                                                        sample_title: UCNR11_beforeT
                                                                                                                                                        source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                        characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                        GSM364652

                                                                                                                                                        Uncertain

                                                                                                                                                        UCNR12_beforeT

                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                          • The required value is not reported.
                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                            • The required value is not reported.
                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                              • The required value is not reported.
                                                                                                                                                              • UCNR12_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                              • UCNR12_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                • UCNR12_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                • UCNR12_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                              Source metadata
                                                                                                                                                              Source name
                                                                                                                                                              Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                              Characteristics
                                                                                                                                                              tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                              Description
                                                                                                                                                              Not reported
                                                                                                                                                              Indexed organism evidence
                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                              Indexed assay evidence
                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                              Source
                                                                                                                                                              GEO
                                                                                                                                                              Original indexed metadata
                                                                                                                                                              sample_accession: GSM364652
                                                                                                                                                              sample_title: UCNR12_beforeT
                                                                                                                                                              source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                              characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                              GSM364653

                                                                                                                                                              Uncertain

                                                                                                                                                              UCNR13_beforeT

                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                    • UCNR13_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                    • UCNR13_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                      • UCNR13_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                      • UCNR13_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                    Source metadata
                                                                                                                                                                    Source name
                                                                                                                                                                    Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                    Characteristics
                                                                                                                                                                    tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                    Description
                                                                                                                                                                    Not reported
                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                    Source
                                                                                                                                                                    GEO
                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                    sample_accession: GSM364653
                                                                                                                                                                    sample_title: UCNR13_beforeT
                                                                                                                                                                    source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                    characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                    GSM364654

                                                                                                                                                                    Uncertain

                                                                                                                                                                    UCNR14_beforeT

                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                          • UCNR14_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                          • UCNR14_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                            • UCNR14_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                            • UCNR14_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                          Source metadata
                                                                                                                                                                          Source name
                                                                                                                                                                          Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                          Characteristics
                                                                                                                                                                          tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                          Description
                                                                                                                                                                          Not reported
                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                          Source
                                                                                                                                                                          GEO
                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                          sample_accession: GSM364654
                                                                                                                                                                          sample_title: UCNR14_beforeT
                                                                                                                                                                          source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                          characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                          GSM364655

                                                                                                                                                                          Uncertain

                                                                                                                                                                          UCNR15_beforeT

                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                • UCNR15_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                • UCNR15_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                  • UCNR15_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                  • UCNR15_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                Source metadata
                                                                                                                                                                                Source name
                                                                                                                                                                                Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                                Characteristics
                                                                                                                                                                                tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                Description
                                                                                                                                                                                Not reported
                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Source
                                                                                                                                                                                GEO
                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                sample_accession: GSM364655
                                                                                                                                                                                sample_title: UCNR15_beforeT
                                                                                                                                                                                source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                                characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                GSM364656

                                                                                                                                                                                Uncertain

                                                                                                                                                                                UCNR16_beforeT

                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                      • UCNR16_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                      • UCNR16_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                        • UCNR16_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                        • UCNR16_beforeT Colonic mucosal biopsy from UC non-responder before first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first infli...
                                                                                                                                                                                      Source metadata
                                                                                                                                                                                      Source name
                                                                                                                                                                                      Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                                      Characteristics
                                                                                                                                                                                      tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                      Description
                                                                                                                                                                                      Not reported
                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                      Source
                                                                                                                                                                                      GEO
                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                      sample_accession: GSM364656
                                                                                                                                                                                      sample_title: UCNR16_beforeT
                                                                                                                                                                                      source_name: Colonic mucosal biopsy from UC non-responder before first infliximab treatment
                                                                                                                                                                                      characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                      GSM422963

                                                                                                                                                                                      Uncertain

                                                                                                                                                                                      UCR1_afterT

                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                            • UCR1_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                            • UCR1_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                              • UCR1_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                              • UCR1_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                            Source metadata
                                                                                                                                                                                            Source name
                                                                                                                                                                                            Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                            Characteristics
                                                                                                                                                                                            tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                            Description
                                                                                                                                                                                            Not reported
                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                            Source
                                                                                                                                                                                            GEO
                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                            sample_accession: GSM422963
                                                                                                                                                                                            sample_title: UCR1_afterT
                                                                                                                                                                                            source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                            characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                            GSM422965

                                                                                                                                                                                            Uncertain

                                                                                                                                                                                            UCR2_afterT

                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                  • UCR2_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                  • UCR2_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                    • UCR2_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                    • UCR2_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                  Source name
                                                                                                                                                                                                  Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                  tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                  Description
                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                  Source
                                                                                                                                                                                                  GEO
                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                  sample_accession: GSM422965
                                                                                                                                                                                                  sample_title: UCR2_afterT
                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                  characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                  GSM422967

                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                  UCR3_afterT

                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                        • UCR3_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                        • UCR3_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                          • UCR3_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                          • UCR3_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                        Source name
                                                                                                                                                                                                        Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                        tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                        Description
                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                        Source
                                                                                                                                                                                                        GEO
                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                        sample_accession: GSM422967
                                                                                                                                                                                                        sample_title: UCR3_afterT
                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                        characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                        GSM422969

                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                        UCR4_afterT

                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                              • UCR4_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                              • UCR4_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                • UCR4_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                • UCR4_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                              Source name
                                                                                                                                                                                                              Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                              tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                              Description
                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Source
                                                                                                                                                                                                              GEO
                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                              sample_accession: GSM422969
                                                                                                                                                                                                              sample_title: UCR4_afterT
                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                              characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                              GSM422971

                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                              UCR5_afterT

                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                    • UCR5_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                    • UCR5_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                      • UCR5_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                      • UCR5_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                    Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                    tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                    sample_accession: GSM422971
                                                                                                                                                                                                                    sample_title: UCR5_afterT
                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                    GSM422973

                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                    UCR6_afterT

                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                          • UCR6_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                          • UCR6_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                            • UCR6_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                            • UCR6_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                          Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                          tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                          sample_accession: GSM422973
                                                                                                                                                                                                                          sample_title: UCR6_afterT
                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                          GSM422975

                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                          UCR7_afterT

                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                • UCR7_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                • UCR7_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                  • UCR7_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                  • UCR7_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                sample_accession: GSM422975
                                                                                                                                                                                                                                sample_title: UCR7_afterT
                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                GSM422977

                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                UCR8_afterT

                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                      • UCR8_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                      • UCR8_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                        • UCR8_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                        • UCR8_afterT Colonic mucosal biopsy from UC responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                      Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                      tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                      sample_accession: GSM422977
                                                                                                                                                                                                                                      sample_title: UCR8_afterT
                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from UC responder after first infliximab treatment
                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: UC; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                      GSM422979

                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                      UCNR1_afterT

                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                            • UCNR1_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                            • UCNR1_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                              • UCNR1_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                              • UCNR1_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                            Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                            tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                            sample_accession: GSM422979
                                                                                                                                                                                                                                            sample_title: UCNR1_afterT
                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                            GSM422981

                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                            UCNR2_afterT

                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                  • UCNR2_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                  • UCNR2_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                    • UCNR2_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                    • UCNR2_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                  Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                  tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                  sample_accession: GSM422981
                                                                                                                                                                                                                                                  sample_title: UCNR2_afterT
                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                  GSM422983

                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                  UCNR3_afterT

                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                        • UCNR3_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                        • UCNR3_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                          • UCNR3_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                          • UCNR3_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                        Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                        tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                        sample_accession: GSM422983
                                                                                                                                                                                                                                                        sample_title: UCNR3_afterT
                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                        GSM422985

                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                        UCNR4_afterT

                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                              • UCNR4_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                              • UCNR4_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                • UCNR4_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                • UCNR4_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                              Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                              tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                              sample_accession: GSM422985
                                                                                                                                                                                                                                                              sample_title: UCNR4_afterT
                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                              GSM422987

                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                              UCNR5_afterT

                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                    • UCNR5_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                    • UCNR5_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                      • UCNR5_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                      • UCNR5_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                    tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                    sample_accession: GSM422987
                                                                                                                                                                                                                                                                    sample_title: UCNR5_afterT
                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                    GSM422989

                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                    UCNR6_afterT

                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                          • UCNR6_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                          • UCNR6_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                            • UCNR6_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                            • UCNR6_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                          Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                          tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                          sample_accession: GSM422989
                                                                                                                                                                                                                                                                          sample_title: UCNR6_afterT
                                                                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                          GSM422991

                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                          UCNR7_afterT

                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                • UCNR7_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                • UCNR7_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                  • UCNR7_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                  • UCNR7_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                sample_accession: GSM422991
                                                                                                                                                                                                                                                                                sample_title: UCNR7_afterT
                                                                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                GSM422993

                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                UCNR8_afterT

                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                      • UCNR8_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                      • UCNR8_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                        • UCNR8_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                        • UCNR8_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                      Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                      tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                      sample_accession: GSM422993
                                                                                                                                                                                                                                                                                      sample_title: UCNR8_afterT
                                                                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                      GSM422995

                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                      UCNR9_afterT

                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                            • UCNR9_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                            • UCNR9_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                              • UCNR9_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                              • UCNR9_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                            Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                            tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                            sample_accession: GSM422995
                                                                                                                                                                                                                                                                                            sample_title: UCNR9_afterT
                                                                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                            GSM422997

                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                            UCNR10_afterT

                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                  • UCNR10_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                  • UCNR10_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                    • UCNR10_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                    • UCNR10_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                  Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                  tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                  sample_accession: GSM422997
                                                                                                                                                                                                                                                                                                  sample_title: UCNR10_afterT
                                                                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                  GSM422999

                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                  UCNR11_afterT

                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                        • UCNR11_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                        • UCNR11_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                          • UCNR11_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                          • UCNR11_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                        Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                        tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                        sample_accession: GSM422999
                                                                                                                                                                                                                                                                                                        sample_title: UCNR11_afterT
                                                                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                        GSM423001

                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                        UCNR12_afterT

                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                              • UCNR12_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                              • UCNR12_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                • UCNR12_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                • UCNR12_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                              Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                              tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                              sample_accession: GSM423001
                                                                                                                                                                                                                                                                                                              sample_title: UCNR12_afterT
                                                                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                              GSM423003

                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                              UCNR13_afterT

                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                    • UCNR13_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                    • UCNR13_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                      • UCNR13_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                      • UCNR13_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                    tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423003
                                                                                                                                                                                                                                                                                                                    sample_title: UCNR13_afterT
                                                                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                    GSM423005

                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                    UCNR14_afterT

                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                          • UCNR14_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                          • UCNR14_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                            • UCNR14_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                            • UCNR14_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                          Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                          tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423005
                                                                                                                                                                                                                                                                                                                          sample_title: UCNR14_afterT
                                                                                                                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                          GSM423007

                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                          UCNR15_afterT

                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                • UCNR15_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                • UCNR15_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                  • UCNR15_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                  • UCNR15_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423007
                                                                                                                                                                                                                                                                                                                                sample_title: UCNR15_afterT
                                                                                                                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                GSM423009

                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                UCNR16_afterT

                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                      • UCNR16_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                      • UCNR16_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                        • UCNR16_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                        • UCNR16_afterT Colonic mucosal biopsy from UC non-responder after first infliximab treatment tissue: Colon; disease: UC; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                      Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                      tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423009
                                                                                                                                                                                                                                                                                                                                      sample_title: UCNR16_afterT
                                                                                                                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from UC non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: UC; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                      GSM423010

                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                      CDcR1_beforeT

                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                            • CDcR1_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                            • CDcR1_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                              • CDcR1_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                              • CDcR1_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                            Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                            tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423010
                                                                                                                                                                                                                                                                                                                                            sample_title: CDcR1_beforeT
                                                                                                                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                            GSM423011

                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                            CDcR1_afterT

                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                  • CDcR1_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                  • CDcR1_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                    • CDcR1_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                    • CDcR1_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                  Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                  tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423011
                                                                                                                                                                                                                                                                                                                                                  sample_title: CDcR1_afterT
                                                                                                                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                  GSM423012

                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                  CDcR2_beforeT

                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                        • CDcR2_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                        • CDcR2_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                          • CDcR2_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                          • CDcR2_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                        Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                        tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423012
                                                                                                                                                                                                                                                                                                                                                        sample_title: CDcR2_beforeT
                                                                                                                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                        GSM423013

                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                        CDcR3_beforeT

                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                              • CDcR3_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                              • CDcR3_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                • CDcR3_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                • CDcR3_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                              Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                              tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423013
                                                                                                                                                                                                                                                                                                                                                              sample_title: CDcR3_beforeT
                                                                                                                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                              GSM423014

                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                              CDcR3_afterT

                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                    • CDcR3_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                    • CDcR3_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                      • CDcR3_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                      • CDcR3_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                    tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423014
                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDcR3_afterT
                                                                                                                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                    GSM423015

                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                    CDcR4_beforeT

                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                          • CDcR4_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                          • CDcR4_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                            • CDcR4_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                            • CDcR4_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                          Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                          tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423015
                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDcR4_beforeT
                                                                                                                                                                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                          GSM423016

                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                          CDcR4_afterT

                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                • CDcR4_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                • CDcR4_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                  • CDcR4_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                  • CDcR4_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423016
                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDcR4_afterT
                                                                                                                                                                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                GSM423017

                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                CDcR5_beforeT

                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                      • CDcR5_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                      • CDcR5_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                        • CDcR5_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                        • CDcR5_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                      Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                      tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423017
                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDcR5_beforeT
                                                                                                                                                                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                      GSM423018

                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                      CDcR5_afterT

                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                            • CDcR5_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                            • CDcR5_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                              • CDcR5_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                              • CDcR5_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                            Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                            tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423018
                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDcR5_afterT
                                                                                                                                                                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                            GSM423019

                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                            CDcR6_beforeT

                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR6_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR6_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR6_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR6_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                  Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423019
                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDcR6_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                  GSM423020

                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                  CDcR6_afterT

                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                        • CDcR6_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                        • CDcR6_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR6_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR6_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                        Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423020
                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDcR6_afterT
                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                        GSM423021

                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                        CDcR7_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                              • CDcR7_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                              • CDcR7_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR7_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR7_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                              Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423021
                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDcR7_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                              GSM423022

                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                              CDcR7_afterT

                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR7_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR7_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcR7_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcR7_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423022
                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDcR7_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423023

                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                    CDcR8_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR8_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR8_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcR8_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcR8_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                          Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423023
                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDcR8_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423024

                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                          CDcR8_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR8_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR8_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR8_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR8_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423024
                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDcR8_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423025

                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                CDcR9_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcR9_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcR9_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcR9_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcR9_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                      Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423025
                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDcR9_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423026

                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                      CDcR9_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcR9_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcR9_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcR9_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcR9_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                            Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423026
                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDcR9_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423027

                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                            CDcR10_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR10_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR10_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR10_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR10_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423027
                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDcR10_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423028

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDcR10_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcR10_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcR10_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR10_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR10_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423028
                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDcR10_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423029

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDcR11_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcR11_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcR11_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR11_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR11_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423029
                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDcR11_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423030

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDcR11_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR11_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcR11_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcR11_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcR11_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423030
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDcR11_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423031

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDcR12_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR12_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcR12_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcR12_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcR12_beforeT Colonic mucosal biopsy from CDc responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423031
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDcR12_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from CDc responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423032

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDcR12_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR12_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcR12_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR12_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcR12_afterT Colonic mucosal biopsy from CDc responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: Yes; before or after first inflixima...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423032
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDcR12_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from CDc responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423033

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CDcNR1_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR1_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR1_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR1_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR1_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423033
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDcNR1_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423034

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CDcNR1_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcNR1_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcNR1_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR1_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR1_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423034
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDcNR1_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423035

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CDcNR2_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcNR2_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcNR2_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR2_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR2_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423035
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDcNR2_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423036

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDcNR2_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR2_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR2_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcNR2_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcNR2_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423036
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDcNR2_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423037

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDcNR3_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR3_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR3_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcNR3_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcNR3_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423037
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDcNR3_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423038

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDcNR3_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR3_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR3_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR3_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR3_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423038
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDcNR3_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423039

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDcNR4_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcNR4_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcNR4_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcNR4_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcNR4_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423039
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDcNR4_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423040

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDcNR4_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcNR4_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcNR4_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcNR4_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcNR4_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423040
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDcNR4_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423041

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CDcNR5_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR5_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR5_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR5_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR5_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423041
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDcNR5_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423042

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CDcNR5_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcNR5_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDcNR5_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR5_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR5_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423042
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDcNR5_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423043

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CDcNR6_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcNR6_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDcNR6_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR6_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR6_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423043
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDcNR6_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423044

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDcNR6_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR6_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDcNR6_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcNR6_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDcNR6_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423044
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDcNR6_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423045

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDcNR7_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR7_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDcNR7_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcNR7_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDcNR7_beforeT Colonic mucosal biopsy from CDc non-responder before first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first infl...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423045
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDcNR7_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Colonic mucosal biopsy from CDc non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423046

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDcNR7_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR7_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDcNR7_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR7_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDcNR7_afterT Colonic mucosal biopsy from CDc non-responder after first infliximab treatment tissue: Colon; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423046
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDcNR7_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Colonic mucosal biopsy from CDc non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Colon; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423047

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    IL1

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • IL1 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • IL1 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • IL1 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • IL1 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423047
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: IL1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423048

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          IL2

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • IL2 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • IL2 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • IL2 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • IL2 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423048
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: IL2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423049

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                IL3

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • IL3 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • IL3 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • IL3 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • IL3 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423049
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: IL3
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423050

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      IL4

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • IL4 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • IL4 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • IL4 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • IL4 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423050
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: IL4
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423051

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            IL5

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • IL5 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • IL5 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • IL5 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • IL5 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423051
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: IL5
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423052

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  IL6

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Sample-local control marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • IL6 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • IL6 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • IL6 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • IL6 Ileal mucosal biopsy from control individual tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423052
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: IL6
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Ileal mucosal biopsy from control individual
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Ileum; disease: Control; response to infliximab: Not applicable; before or after first infliximab treatment: Not applicable

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423053

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDiR1_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR1_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR1_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR1_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR1_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423053
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDiR1_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423054

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDiR1_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR1_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR1_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR1_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR1_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423054
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDiR1_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423055

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDiR2_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR2_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR2_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR2_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR2_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423055
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDiR2_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423056

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDiR2_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR2_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR2_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR2_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR2_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423056
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDiR2_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423057

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CDiR3_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR3_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR3_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR3_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR3_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423057
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDiR3_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423058

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CDiR3_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR3_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR3_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR3_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR3_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423058
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDiR3_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423059

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CDiR4_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR4_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR4_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR4_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR4_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423059
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDiR4_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423060

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDiR4_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR4_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR4_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR4_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR4_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423060
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDiR4_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423061

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDiR5_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR5_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR5_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR5_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR5_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423061
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDiR5_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423062

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDiR5_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR5_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR5_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR5_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR5_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423062
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDiR5_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423063

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDiR6_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR6_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR6_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR6_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR6_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423063
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDiR6_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423064

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDiR6_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR6_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiR6_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR6_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR6_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423064
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDiR6_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423065

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CDiR7_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR7_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiR7_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR7_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR7_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423065
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDiR7_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423066

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CDiR7_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR7_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiR7_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR7_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiR7_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423066
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDiR7_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423067

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CDiR8_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR8_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiR8_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR8_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiR8_beforeT Ileal mucosal biopsy from CDi responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423067
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDiR8_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Ileal mucosal biopsy from CDi responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423068

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDiR8_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR8_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiR8_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR8_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiR8_afterT Ileal mucosal biopsy from CDi responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab t...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423068
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDiR8_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Ileal mucosal biopsy from CDi responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Ileum; disease: CD; response to infliximab: Yes; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423069

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDiNR1_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR1_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR1_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR1_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR1_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423069
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDiNR1_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423070

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDiNR1_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR1_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR1_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR1_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR1_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423070
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDiNR1_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423071

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDiNR2_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR2_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR2_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR2_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR2_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423071
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDiNR2_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423072

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDiNR2_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR2_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR2_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR2_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR2_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423072
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDiNR2_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423073

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CDiNR3_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR3_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR3_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR3_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR3_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423073
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDiNR3_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423074

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CDiNR3_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR3_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR3_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR3_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR3_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423074
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDiNR3_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423075

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CDiNR4_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR4_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR4_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR4_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR4_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423075
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDiNR4_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423076

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDiNR4_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR4_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR4_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR4_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR4_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423076
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDiNR4_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423077

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDiNR5_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR5_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR5_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR5_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR5_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423077
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDiNR5_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423078

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDiNR5_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR5_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR5_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR5_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR5_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423078
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDiNR5_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423079

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDiNR6_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR6_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR6_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR6_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR6_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423079
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDiNR6_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423080

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDiNR6_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR6_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR6_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR6_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR6_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423080
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDiNR6_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM423081

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CDiNR7_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR7_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR7_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR7_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR7_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM423081
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: CDiNR7_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM423082

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CDiNR7_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR7_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR7_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR7_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR7_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM423082
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: CDiNR7_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM423083

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CDiNR8_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR8_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR8_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR8_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR8_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM423083
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: CDiNR8_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM423084

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CDiNR8_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR8_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • CDiNR8_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR8_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR8_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM423084
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: CDiNR8_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM423085

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        CDiNR9_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR9_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • CDiNR9_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR9_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR9_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflix...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM423085
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: CDiNR9_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM423086

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CDiNR9_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR9_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CDiNR9_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR9_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • CDiNR9_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixim...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM423086
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: CDiNR9_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM423087

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CDiNR10_beforeT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR10_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first infli...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CDiNR10_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first infli...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR10_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first infli...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CDiNR10_beforeT Ileal mucosal biopsy from CDi non-responder before first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first infli...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM423087
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: CDiNR10_beforeT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: Ileal mucosal biopsy from CDi non-responder before first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: Before first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM423088

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CDiNR10_afterT

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Explicit characteristic comparison arm detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR10_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • CDiNR10_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR10_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CDiNR10_afterT Ileal mucosal biopsy from CDi non-responder after first infliximab treatment tissue: Ileum; disease: CD; response to infliximab: No; before or after first inflixi...
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM423088
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: CDiNR10_afterT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: Ileal mucosal biopsy from CDi non-responder after first infliximab treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: tissue: Ileum; disease: CD; response to infliximab: No; before or after first infliximab treatment: After first infliximab treatment

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Excluded samples (0)

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                No excluded samples.