GSE172372

Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

5 case / 12 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source: GEO
Assay: bulk RNA-seq
Organism: Homo sapiens
Whole-study samples: 17 samples
Specimen: Tissue
Reported/interpreted study design: Treatment vs control Design classification does not establish patient pairs.

Comparison type: Tumor vs normal
Contributors: Hertweck A, Jenner RG, Omer OS, Lord GM
Contact name: Arnulf Hertweck
Submission date: 2021-04-19
Last update: 2022-06-17
Organization: University College London
Department: UCL Cancer Institute
Public date: 2022-06-17
Experiment types: Expression profiling by high throughput sequencing
Platforms: GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Series type: Series
SubSeries: Not available
BioProject: PRJNA723035

Summary

The treatment of auto-inflammatory diseases is often limited by resistance to single cytokine blockade, primarily anti-TNF antibodies. This is a particularly important cause of treatment failure in inflammatory bowel disease (IBD). The transcription factor T-bet is a critical regulator of intestinal homeostasis and is genetically linked to mucosal inflammation by causal variation in its binding sites. However, transcription factors such as T-bet are difficult to target therapeutically. Using CDK9 inhibitors, we show that modulation of P-TEFb (cyclinT1/CDK9), a transcriptional elongation factor downstream of T-bet, potently represses genes responsible for pro-inflammatory signalling, and in particular genes regulated by T-bet. Remarkably, CDK9 inhibition targets genes that are highly expressed in anti-TNF resistant IBD and that predict non-response to anti-TNF therapy. Collectively, our findings reveal CDK9 as a potential target in anti-TNF resistant IBD, which has the potential for rapid translation to the clinic.

Overall design

poly-A+ RNA-Seq in human primary and secondary stimulated colonic CD4+ T cells from Crohn's disease and ulcerative colitis patients treated with NVP-2 or control

Source Evidence

4 sources

Source	Contribution	Status
GEO	Original dataset metadata, sample metadata, source links, and GEO data availability flags. Sample records 17 GSM samples	Primary source
recount3	Planned trusted source for processed count availability.	No match found
Expression Atlas	Planned source for curated expression experiment links.	No match found
PubMed	Primary GEO citations and related PubMed articles that mention this dataset. 1 linked publication 1 DOI Primary publication Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology, 2022 PubMed DOI	Available

Metadata Quality Components

Persisted metadata quality

100 pts

Clarity: 100%
Weight: 100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: Treatment status metadata normalized where treatment is part of the comparison. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Ready after review

97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Standard analyst review

Proceed only after the analyst confirms grouping, exclusions, and source files.

By Siftome standards, no expert review was triggered.

Why This Is Ranked Here

Tumor vs normal

Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

Disease context Crohn's disease, inflammatory bowel disease, ulcerative colitis Disease context came from Normalization rules.
Likely case group Treated 5 samples
Likely control group Untreated 12 samples

Intent Interpretation

Downgrade or exclusion reason Downgraded for tissue search because it is a treatment/control experiment. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

Comparison: Treatment vs control. Specimen: Tissue. Comparison suitability: 0%.
Prioritized assay: bulk RNA-seq is the active assay expectation.
Interpreted disease metadata: Crohn's disease, Inflammatory bowel disease, Ulcerative colitis.
Processed data is available for downstream review.
External evidence: PubMed links 1 publication; 1 DOI available: PMID 35660024.
Publication context: Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease.. Cellular and molecular gastroenterology and hepatology, 2022. PMID 35660024. DOI 10.1016/j.jcmgh.2022.05.011.

Cautions

Downgraded for tissue search because it is a treatment/control experiment.
Treatment/control experiment downgraded because this ranking targets tumor-vs-normal tissue comparisons.
Overall score capped because comparison suitability is weak for the selected search intent.
Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Multiple disease or phenotype arms were detected. The displayed grouping summarizes the full dataset; select the requested disease-specific contrast before analysis.

Normalized Fields

99 fields

Field Value Source Derived by Confidence Evidence Reason

anatomical_source colon GSM5253626 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253627 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253628 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253629 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253630 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253631 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253632 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253633 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253634 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253635 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253636 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253637 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253638 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253639 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253640 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253641 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM5253642 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colonic source_name: Colonic CD4+ T cells sample-anatomical-source-v1 sample-local anatomical source

assay_type bulk RNA-seq GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence bulk rna-seq dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... keyword match keyword match: bulk rna-seq

cell_population CD4 T cells GSM5253626 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO US1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253627 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253628 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells NVP2 RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: NVP-2; stimulation: 3h PMA + ionomomycin (+NVP-2); stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253629 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO US2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimul... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253630 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; ... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253631 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells NVP2 RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin ... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253632 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO US1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253633 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO RS1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253634 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO US2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253635 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253636 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells NVP2 RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ ... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253637 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO US1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253638 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253639 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells NVP2 RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 3h PMA + ionomomycin (+ NVP-2); stimulation time point: day 0 controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253640 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO US2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253641 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells DMSO RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

cell_population CD4 T cells GSM5253642 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence cd4+ t cells NVP2 RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ ... controlled vocabulary controlled vocabulary cell population match: cd4+ t cells

control_type vehicle control GSM5253626 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO US1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253627 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253629 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO US2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimul... controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253630 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; ... controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253632 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO US1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253633 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253634 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO US2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253635 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253637 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO US1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253638 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253640 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO US2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary control type match: dmso

control_type vehicle control GSM5253641 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary control type match: dmso

disease Crohn's disease GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease inflammatory bowel disease GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflammatory bowel disease dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... controlled vocabulary controlled vocabulary disease match: inflammatory bowel disease

disease ulcerative colitis GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM5253626 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis DMSO US1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM5253627 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis DMSO RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM5253628 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis NVP2 RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: NVP-2; stimulation: 3h PMA + ionomomycin (+NVP-2); stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM5253629 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis DMSO US2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimul... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM5253630 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis DMSO RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM5253631 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis NVP2 RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin ... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease Crohn's disease GSM5253632 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO US1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253633 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO RS1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253634 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO US2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253635 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253636 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease NVP2 RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ ... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253637 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO US1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253638 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253639 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease NVP2 RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 3h PMA + ionomomycin (+ NVP-2); stimulation time point: day 0 controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253640 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO US2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253641 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease DMSO RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM5253642 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease NVP2 RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ ... controlled vocabulary controlled vocabulary disease match: Crohn's disease

organism Homo sapiens GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence homo sapiens dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... keyword match keyword match: homo sapiens

tissue colon GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... controlled vocabulary controlled vocabulary tissue match: colonic

tissue intestine GSE172372 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence intestinal dataset_accession: GSE172372 dataset_title: Cyclin-dependent kinase 9 is a therapeutic target for anti-TNF resistant inflammatory bowel disease organism: Homo sapiens assay_type... controlled vocabulary controlled vocabulary tissue match: intestinal

tissue colon GSM5253626 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO US1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253627 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253628 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic NVP2 RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: NVP-2; stimulation: 3h PMA + ionomomycin (+NVP-2); stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253629 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO US2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimul... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253630 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; ... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253631 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic NVP2 RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin ... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253632 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO US1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253633 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO RS1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253634 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO US2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253635 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253636 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic NVP2 RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ ... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253637 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO US1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253638 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253639 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic NVP2 RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 3h PMA + ionomomycin (+ NVP-2); stimulation time point: day 0 controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253640 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO US2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253641 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic DMSO RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary tissue match: colonic

tissue colon GSM5253642 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence colonic NVP2 RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: NVP-2; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ ... controlled vocabulary controlled vocabulary tissue match: colonic

treatment_status untreated GSM5253626 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence unstimulated DMSO US1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary treatment status match: unstimulated

treatment_status untreated GSM5253627 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS1 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary treatment status match: dmso

treatment_status untreated GSM5253629 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence unstimulated DMSO US2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimul... controlled vocabulary controlled vocabulary treatment status match: unstimulated

treatment_status untreated GSM5253630 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS2 UC1 Colonic CD4+ T cells disease: Ulcerative colitis; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; ... controlled vocabulary controlled vocabulary treatment status match: dmso

treatment_status untreated GSM5253632 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence unstimulated DMSO US1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary treatment status match: unstimulated

treatment_status untreated GSM5253633 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS1 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary treatment status match: dmso

treatment_status untreated GSM5253634 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence unstimulated DMSO US2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary treatment status match: unstimulated

treatment_status untreated GSM5253635 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS2 CD1 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary treatment status match: dmso

treatment_status untreated GSM5253637 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence unstimulated DMSO US1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: Unstimulated; stimulation time point: day 0 controlled vocabulary controlled vocabulary treatment status match: unstimulated

treatment_status untreated GSM5253638 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS1 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 3h PMA + ionomomycin; stimulation time point: day 0 controlled vocabulary controlled vocabulary treatment status match: dmso

treatment_status untreated GSM5253640 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence unstimulated DMSO US2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; stimulati... controlled vocabulary controlled vocabulary treatment status match: unstimulated

treatment_status untreated GSM5253641 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence dmso DMSO RS2 CD2 Colonic CD4+ T cells disease: Crohn's disease; treatment: DMSO; stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; sti... controlled vocabulary controlled vocabulary treatment status match: dmso

Sample Group Preview

17 rows shown Show Hide

Study totals: Case 5 | Control 12 | Unassigned 0 | Excluded 0 | Ambiguous 0 17 rows shown

Group	Role	Accession	Title	Source / characteristics	Reason
Treated	Case	GSM5253628	NVP2 RS1 UC1	Colonic CD4+ T cells Disease: Ulcerative colitis; Treatment: NVP-2; Stimulation: 3h PMA + ionomomycin (+NVP-2); Stimulation time point: Day 0	Explicit characteristic comparison arm detected.
Treated	Case	GSM5253631	NVP2 RS2 UC1	Colonic CD4+ T cells Disease: Ulcerative colitis; Treatment: NVP-2; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ NVP-2); Stimulation time point: Day 5	Explicit characteristic comparison arm detected.
Treated	Case	GSM5253636	NVP2 RS2 CD1	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: NVP-2; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ NVP-2); Stimulation time point: Day 5	Explicit characteristic comparison arm detected.
Treated	Case	GSM5253639	NVP2 RS1 CD2	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: NVP-2; Stimulation: 3h PMA + ionomomycin (+ NVP-2); Stimulation time point: Day 0	Explicit characteristic comparison arm detected.
Treated	Case	GSM5253642	NVP2 RS2 CD2	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: NVP-2; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin (+ NVP-2); Stimulation time point: Day 5	Explicit characteristic comparison arm detected.
Untreated	Control	GSM5253626	DMSO US1 UC1	Colonic CD4+ T cells Disease: Ulcerative colitis; Treatment: DMSO; Stimulation: Unstimulated; Stimulation time point: Day 0	Treatment control marker detected.
Untreated	Control	GSM5253627	DMSO RS1 UC1	Colonic CD4+ T cells Disease: Ulcerative colitis; Treatment: DMSO; Stimulation: 3h PMA + ionomomycin; Stimulation time point: Day 0	Treatment control marker detected.
Untreated	Control	GSM5253629	DMSO US2 UC1	Colonic CD4+ T cells Disease: Ulcerative colitis; Treatment: DMSO; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; Stimulation time point: Day 5	Treatment control marker detected.
Untreated	Control	GSM5253630	DMSO RS2 UC1	Colonic CD4+ T cells Disease: Ulcerative colitis; Treatment: DMSO; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; Stimulation time point: Day 5	Treatment control marker detected.
Untreated	Control	GSM5253632	DMSO US1 CD1	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: Unstimulated; Stimulation time point: Day 0	Treatment control marker detected.
Untreated	Control	GSM5253633	DMSO RS1 CD1	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: 3h PMA + ionomomycin; Stimulation time point: Day 0	Treatment control marker detected.
Untreated	Control	GSM5253634	DMSO US2 CD1	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; Stimulation time point: Day 5	Treatment control marker detected.
Untreated	Control	GSM5253635	DMSO RS2 CD1	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; Stimulation time point: Day 5	Treatment control marker detected.
Untreated	Control	GSM5253637	DMSO US1 CD2	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: Unstimulated; Stimulation time point: Day 0	Treatment control marker detected.
Untreated	Control	GSM5253638	DMSO RS1 CD2	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: 3h PMA + ionomomycin; Stimulation time point: Day 0	Treatment control marker detected.
Untreated	Control	GSM5253640	DMSO US2 CD2	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> Unstimulated; Stimulation time point: Day 5	Treatment control marker detected.
Untreated	Control	GSM5253641	DMSO RS2 CD2	Colonic CD4+ T cells Disease: Crohn's disease; Treatment: DMSO; Stimulation: 72h plate-bound anti-CD3 and anti-CD28 (2 mg/ml) -> 48h rest -> 3h PMA + ionomycin; Stimulation time point: Day 5	Treatment control marker detected.

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Use as Discovery Cohort