GSE206285

Efficacy and safety of ustekinumab treatment in patients with ulcerative colitis

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

364 case / 204 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source
GEO
Assay
microarray
Organism
Homo sapiens
Whole-study samples
568 samples
Specimen
Biopsy
Reported/interpreted study design
Disease/model vs control Design classification does not establish patient pairs.
Comparison type
Tumor vs normal
Contributors
Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, Yang F, Lo J, Alberts E, Costa Sa AC, Niazi U, Friedman J, Long A, Ding Y, Carey C, Lamb C, Saqi M, Madgwick M, Gul L, Treveil A, Korcsmaros T, MacDonald T, Lord G, Bewick G, Powell N
Contact name
Nick Powell
Submission date
2022-06-16
Last update
2024-03-15
Organization
Imperial College London
Department
Department of Metabolism, Digestion and Reproduction
Public date
2022-08-08
Experiment types
Expression profiling by array
Platforms
GPL13158 [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate
Series type
Series
SubSeries
Not available
BioProject
PRJNA849958

Summary

UNIFI was a randomized placebo-controlled phase 3 clinical trial evaluating the efficacy and safety of ustekinumab (ClinicalTrials.gov Identifier: NCT02407236). Gene expression profiling by microarrays was carried out at baseline on biopsies from the sigmoid colon (15-20cm from anal verge) of patients (n=550) with moderate-to-severe ulcerative colitis and of healthy subjects (n=18). Ulcerative colitis patients received placebo (n=186) or ustekinumab (n=364). The effects of two different dosages were investigated: 130mg (n=180) and 6mg/kg (n=184).

Overall design

Patients with moderate-to-severe ulcerative colitis were treated with ustekinumab (n=364) or placebo (n=186) at week 0. Biopsy samples were collected from 550 patients and 18 healthy subjects at baseline for RNA extraction and microarray profiling.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
568 GSM samples
 Primary source
recount3

Planned trusted source for processed count availability.

 No match found
Expression Atlas

Planned source for curated expression experiment links.

 No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

11 linked publications 11 DOIs

Primary publication

  1. Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease. Cell reports, 2022
  2. Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy. Nature communications, 2022
  3. Biopsy and blood-based molecular biomarker of inflammation in IBD. Gut, 2023

Related publications

  1. Utilizing an integrated bioinformatics and machine learning approach to uncover biomarkers linking ulcerative colitis to purine metabolism-related genes. Heliyon, 2024
  2. Molecular insights into ulcerative colitis and orbital inflammation. Scientific reports, 2025
  3. Formylated Peptide Receptor-1-Mediated Gut Inflammation as a Therapeutic Target in Inflammatory Bowel Disease. Crohn's & colitis 360, 2024
  4. PANoptosis and Autophagy-Related Molecular Signature and Immune Landscape in Ulcerative Colitis: Integrated Analysis and Experimental Validation. Journal of inflammation research, 2024
  5. Identification of neutrophil extracellular trap-related biomarkers in ulcerative colitis based on bioinformatics and machine learning. Frontiers in genetics, 2025
  6. Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease. Frontiers in immunology, 2025
  7. A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning. Frontiers in immunology, 2026
  8. A multi-machine learning framework identifies novel PANoptosis-related biomarkers and their immune landscape in ulcerative colitis: Insights from transcriptomics and experimental validation. Frontiers in immunology, 2026
Available

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Ready after review
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

  • Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
  • Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Ulcerative colitis 364 samples
  • Likely control group Mixed controls 204 samples

Intent Interpretation

  • Downgrade or exclusion reason Downgraded assay: microarray cohorts are separated from the RNA-seq intent. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Biopsy. Comparison suitability: 0%.
  • Interpreted disease metadata: Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 11 publications; 11 DOIs available: PMID 36109152, PMID 36170836, PMID 36192482, PMID 38352118, PMID 38800594.
  • Publication context: Biopsy and blood-based molecular biomarker of inflammation in IBD.. Gut, 2023. PMID 36109152. DOI 10.1136/gutjnl-2021-326451.
  • Publication context: Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease.. Cell reports, 2022. PMID 36170836. DOI 10.1016/j.celrep.2022.111439.
  • Publication context: Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy.. Nature communications, 2022. PMID 36192482. DOI 10.1038/s41467-022-33331-8.
  • Publication context: 8 additional linked PubMed publications are available.

Cautions

  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Microarray expression context downgraded below primary bulk RNA-seq for the default tissue ranking.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because microarray cohorts should be compared separately from RNA-seq cohorts.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

showing 500 of 3066 fields

Sample Group Preview

showing 100 of 568 preview rows Show Hide
Study totals: Case 364 | Control 204 | Unassigned 0 | Excluded 0 | Ambiguous 0 showing 100 of 568 preview rows
Group Role Accession Title Source / characteristics Reason
Ulcerative colitis Case GSM6249277 CNTO1275UCO3001-100001 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100001; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249278 CNTO1275UCO3001-100002 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100002; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249280 CNTO1275UCO3001-100004 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100004; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249281 CNTO1275UCO3001-100005 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100005; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249282 CNTO1275UCO3001-100007 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100007; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249284 CNTO1275UCO3001-100009 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100009; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: Y; Clinical remission at week 8: Y Case marker detected.
Ulcerative colitis Case GSM6249285 CNTO1275UCO3001-100010 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100010; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249286 CNTO1275UCO3001-100011 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100011; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249289 CNTO1275UCO3001-100015 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100015; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249290 CNTO1275UCO3001-100018 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100018; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: Y; Clinical remission at week 8: Y Case marker detected.
Ulcerative colitis Case GSM6249293 CNTO1275UCO3001-100022 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100022; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249294 CNTO1275UCO3001-100023 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100023; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: Y; Clinical remission at week 8: Y Case marker detected.
Ulcerative colitis Case GSM6249296 CNTO1275UCO3001-100026 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100026; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249297 CNTO1275UCO3001-100028 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100028; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249298 CNTO1275UCO3001-100030 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100030; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249299 CNTO1275UCO3001-100031 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100031; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249300 CNTO1275UCO3001-100032 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100032; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249301 CNTO1275UCO3001-100034 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100034; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249302 CNTO1275UCO3001-100036 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100036; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249303 CNTO1275UCO3001-100037 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100037; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249304 CNTO1275UCO3001-100040 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100040; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249305 CNTO1275UCO3001-100043 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100043; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249306 CNTO1275UCO3001-100045 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100045; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249307 CNTO1275UCO3001-100046 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100046; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249309 CNTO1275UCO3001-100048 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100048; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: Y; Clinical remission at week 8: Y Case marker detected.
Ulcerative colitis Case GSM6249310 CNTO1275UCO3001-100050 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100050; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249311 CNTO1275UCO3001-100051 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100051; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: NA; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249313 CNTO1275UCO3001-100057 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100057; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249316 CNTO1275UCO3001-100060 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100060; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249317 CNTO1275UCO3001-100062 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100062; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249319 CNTO1275UCO3001-100064 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100064; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249322 CNTO1275UCO3001-100069 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100069; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249323 CNTO1275UCO3001-100074 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100074; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249330 CNTO1275UCO3001-100083 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100083; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249332 CNTO1275UCO3001-100085 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100085; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249333 CNTO1275UCO3001-100087 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100087; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249334 CNTO1275UCO3001-100089 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100089; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249335 CNTO1275UCO3001-100091 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100091; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249336 CNTO1275UCO3001-100092 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100092; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249337 CNTO1275UCO3001-100095 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100095; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249338 CNTO1275UCO3001-100096 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100096; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249339 CNTO1275UCO3001-100097 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100097; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249340 CNTO1275UCO3001-100098 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100098; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249341 CNTO1275UCO3001-100100 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100100; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: Y; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249342 CNTO1275UCO3001-100101 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100101; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (520 mg); Mucosal healing at week 8: Y; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249343 CNTO1275UCO3001-100102 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100102; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249345 CNTO1275UCO3001-100106 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100106; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249348 CNTO1275UCO3001-100110 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100110; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 130 mg IV; Mucosal healing at week 8: Y; Clinical remission at week 8: Y Case marker detected.
Ulcerative colitis Case GSM6249349 CNTO1275UCO3001-100111 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100111; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
Ulcerative colitis Case GSM6249350 CNTO1275UCO3001-100112 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100112; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Ustekinumab 6 mg/kg (390 mg); Mucosal healing at week 8: N; Clinical remission at week 8: N Case marker detected.
314 additional case samples are hidden from this preview.
Vehicle control Control GSM6249279 CNTO1275UCO3001-100003 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100003; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249283 CNTO1275UCO3001-100008 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100008; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249287 CNTO1275UCO3001-100013 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100013; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249288 CNTO1275UCO3001-100014 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100014; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249291 CNTO1275UCO3001-100020 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100020; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249292 CNTO1275UCO3001-100021 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100021; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249295 CNTO1275UCO3001-100024 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100024; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249308 CNTO1275UCO3001-100047 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100047; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249312 CNTO1275UCO3001-100054 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100054; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249314 CNTO1275UCO3001-100058 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100058; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: Y; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249315 CNTO1275UCO3001-100059 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100059; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249318 CNTO1275UCO3001-100063 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100063; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249320 CNTO1275UCO3001-100065 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100065; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249321 CNTO1275UCO3001-100068 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100068; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249324 CNTO1275UCO3001-100075 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100075; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249325 CNTO1275UCO3001-100076 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100076; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249326 CNTO1275UCO3001-100078 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100078; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249327 CNTO1275UCO3001-100080 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100080; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249328 CNTO1275UCO3001-100081 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100081; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: Y; Clinical remission at week 8: Y Sample-local control marker detected.
Vehicle control Control GSM6249329 CNTO1275UCO3001-100082 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100082; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249331 CNTO1275UCO3001-100084 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100084; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249344 CNTO1275UCO3001-100103 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100103; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249346 CNTO1275UCO3001-100108 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100108; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249347 CNTO1275UCO3001-100109 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100109; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249353 CNTO1275UCO3001-100116 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100116; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249354 CNTO1275UCO3001-100118 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100118; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249356 CNTO1275UCO3001-100122 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100122; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249358 CNTO1275UCO3001-100124 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100124; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249360 CNTO1275UCO3001-100126 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100126; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: Y Sample-local control marker detected.
Vehicle control Control GSM6249363 CNTO1275UCO3001-100130 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100130; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249365 CNTO1275UCO3001-100132 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100132; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249367 CNTO1275UCO3001-100135 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100135; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249377 CNTO1275UCO3001-100146 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100146; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249380 CNTO1275UCO3001-100149 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100149; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249381 CNTO1275UCO3001-100150 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100150; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: Y; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249384 CNTO1275UCO3001-100154 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100154; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249387 CNTO1275UCO3001-100157 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100157; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249388 CNTO1275UCO3001-100160 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100160; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249394 CNTO1275UCO3001-100168 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100168; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249398 CNTO1275UCO3001-100174 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100174; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249403 CNTO1275UCO3001-100181 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100181; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249405 CNTO1275UCO3001-100183 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100183; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249407 CNTO1275UCO3001-100185 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100185; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249411 CNTO1275UCO3001-100191 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100191; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249412 CNTO1275UCO3001-100192 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100192; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249419 CNTO1275UCO3001-100203 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100203; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249421 CNTO1275UCO3001-100206 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100206; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249429 CNTO1275UCO3001-100215 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100215; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249431 CNTO1275UCO3001-100218 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100218; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
Vehicle control Control GSM6249434 CNTO1275UCO3001-100221 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO1275UCO3001-100221; Visit: WEEK I-0; Diagnosis: Ulcerative colitis; Treatment: Placebo IV; Mucosal healing at week 8: N; Clinical remission at week 8: N Sample-local control marker detected.
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External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.