GSE212849

Prediction of Golimumab Response in the PROgECT Phase 2a Open-Label Trial of Patients With Ulcerative Colitis

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

84 case / 0 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source
GEO
Assay
microarray
Organism
Homo sapiens
Whole-study samples
84 samples
Specimen
Biopsy
Reported/interpreted study design
Unclear study design Design classification does not establish patient pairs.
Comparison type
Tumor vs normal
Contributors
Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, Yang F, Lo J, Alberts E, Costa Sa AC, Niazi U, Friedman J, Long A, Ding Y, Carey C, Lamb C, Saqi M, Madgwick M, Gul L, Treveil A, Korcsmaros T, MacDonald T, Lord G, Bewick G, Powell N
Contact name
Nick Powell
Submission date
2022-09-07
Last update
2022-12-08
Organization
Imperial College London
Department
Department of Metabolism, Digestion and Reproduction
Public date
2022-09-08
Experiment types
Expression profiling by array
Platforms
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Series type
Series
SubSeries
Not available
BioProject
PRJNA877642

Summary

PROgECT (ClinicalTrials.gov Identifier: NCT01988961) was a multicenter, open-label study evaluating the accuracy of a probe-set panel in predicting response to golimumab treatment in participants with moderately to severely active ulcerative colitis (UC). Biopsy samples (collected 15 to 20 cm from the anal verge) were taken at screening from 84 patients and used for RNA extraction and profiling by microarrays. All patients enrolled in the study received the approved induction dose regimen of subcutaneous (SC) golimumab.

Overall design

A gene expression profiling study was conducted in which colon biopsy samples were collected for RNA extraction and hybridization to microarrays from patients (n=84) with moderate-to-severe ulcerative colitis.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
84 GSM samples
 Primary source
recount3

Planned trusted source for processed count availability.

 No match found
Expression Atlas

Planned source for curated expression experiment links.

 No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

1 linked publication 1 DOI

Primary publication

  1. Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease. Cell reports, 2022
Available

Metadata Quality Components

Persisted metadata quality

93 pts
Clarity
93%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Only one side of the comparison is clearly grouped. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Not ready
55% DE readiness

Contrast completeness

10/25 pts

Only one side of the contrast is present; downstream DE needs both groups.

Minimum group size

0/20 pts

Minimum group size cannot be evaluated until a complete contrast exists.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

0/10 pts

Critical warnings must be resolved before downstream analysis.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • No complete case/control contrast is available.
  • Critical dataset warnings must be resolved.

Next Steps

  • Resolve critical warnings before downstream analysis.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Blocked

No complete case/control grouping exists yet.

Review the sample grouping table and assign both case and control groups.

Minimum sample count met

Blocked

At least one group has fewer than 2 samples.

Choose a larger dataset or merge only scientifically valid groups.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

Analysis preparation checklist contains blocked items.

No complete case/control or treatment/control contrast is available.

At least one comparison group has fewer than two samples.

Critical dataset warnings are present.

Assay context may require expert handling before DESeq2-style analysis.

Study design is model-system or unclear and should be reviewed before analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Ulcerative colitis 84 samples
  • Likely control group No control group detected 0 samples

Intent Interpretation

  • Downgrade or exclusion reason Comparison: Unclear study design. Specimen: Biopsy. Comparison suitability: 0%. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Interpreted disease metadata: Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 1 publication; 1 DOI available: PMID 36170836.
  • Publication context: Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease.. Cell reports, 2022. PMID 36170836. DOI 10.1016/j.celrep.2022.111439.

Cautions

  • Comparison: Unclear study design. Specimen: Biopsy. Comparison suitability: 0%.
  • Downgraded for tissue search because study design or specimen source is unclear.
  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Unclear study design downgraded for patient tissue tumor-vs-normal search intent.
  • Missing or unclear metadata. Unclear study design downgraded for patient tissue tumor-vs-normal search intent.
  • Microarray expression context downgraded below primary bulk RNA-seq for the default tissue ranking.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because microarray cohorts should be compared separately from RNA-seq cohorts.
  • Missing or unclear metadata. Comparison - Unclear study design. Specimen - Biopsy. Comparison suitability: 0%.
  • Missing or unclear metadata. Downgraded for tissue search because study design or specimen source is unclear.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

424 fields

Sample Group Preview

showing 50 of 84 preview rows Show Hide
Study totals: Case 84 | Control 0 | Unassigned 0 | Excluded 0 | Ambiguous 0 showing 50 of 84 preview rows
Group Role Accession Title Source / characteristics Reason
Ulcerative colitis Case GSM6557038 CNTO148UCO2001-100002 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100002; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557039 CNTO148UCO2001-100003 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100003; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557041 CNTO148UCO2001-100007 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100007; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557042 CNTO148UCO2001-100009 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100009; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557044 CNTO148UCO2001-100010 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100010; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557045 CNTO148UCO2001-100012 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100012; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557047 CNTO148UCO2001-100017 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100017; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557048 CNTO148UCO2001-100019 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100019; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557049 CNTO148UCO2001-100020 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100020; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: Y Case marker detected.
Ulcerative colitis Case GSM6557051 CNTO148UCO2001-100021 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100021; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557052 CNTO148UCO2001-100027 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100027; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: Y Case marker detected.
Ulcerative colitis Case GSM6557054 CNTO148UCO2001-100028 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100028; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557055 CNTO148UCO2001-100029 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100029; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557057 CNTO148UCO2001-100030 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100030; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557058 CNTO148UCO2001-100032 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100032; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557059 CNTO148UCO2001-100033 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100033; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557061 CNTO148UCO2001-100035 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100035; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557062 CNTO148UCO2001-100036 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100036; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557063 CNTO148UCO2001-100038 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100038; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557065 CNTO148UCO2001-100042 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100042; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557066 CNTO148UCO2001-100045 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100045; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557068 CNTO148UCO2001-100046 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100046; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557069 CNTO148UCO2001-100047 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100047; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557071 CNTO148UCO2001-100050 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100050; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557072 CNTO148UCO2001-100051 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100051; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557074 CNTO148UCO2001-100052 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100052; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557075 CNTO148UCO2001-100053 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100053; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557076 CNTO148UCO2001-100054 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100054; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557078 CNTO148UCO2001-100058 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100058; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557079 CNTO148UCO2001-100062 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100062; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557080 CNTO148UCO2001-100064 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100064; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557082 CNTO148UCO2001-100065 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100065; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557083 CNTO148UCO2001-100066 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100066; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: Y Case marker detected.
Ulcerative colitis Case GSM6557084 CNTO148UCO2001-100067 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100067; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557086 CNTO148UCO2001-100070 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100070; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557087 CNTO148UCO2001-100076 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100076; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557089 CNTO148UCO2001-100077 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100077; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: Y Case marker detected.
Ulcerative colitis Case GSM6557090 CNTO148UCO2001-100078 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100078; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: Y Case marker detected.
Ulcerative colitis Case GSM6557092 CNTO148UCO2001-100079 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100079; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557093 CNTO148UCO2001-100080 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100080; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557094 CNTO148UCO2001-100081 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100081; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: Y Case marker detected.
Ulcerative colitis Case GSM6557096 CNTO148UCO2001-100082 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100082; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: Y; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557097 CNTO148UCO2001-100084 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100084; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557098 CNTO148UCO2001-100085 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100085; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557100 CNTO148UCO2001-100086 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100086; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557101 CNTO148UCO2001-100089 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100089; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557102 CNTO148UCO2001-100091 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100091; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557104 CNTO148UCO2001-100092 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100092; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557105 CNTO148UCO2001-100095 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100095; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
Ulcerative colitis Case GSM6557106 CNTO148UCO2001-100097 colon biopsy week 0 Colon biopsy Tissue: Colon; Donor id: CNTO148UCO2001-100097; Visit: Week 0; Diagnosis: Ulcerative colitis; Treatment: Golimumab 200mg; Mucosal healing at week 6: N; Clinical remission at week 6: N Case marker detected.
34 additional case samples are hidden from this preview.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.