GSE227747

Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle Apoptosis, Proliferative Disorders, and Autonomic Nervous Abnormality in Crohn's Disease.

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

10 case / 5 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source: GEO
Assay: bulk RNA-seq
Organism: Homo sapiens
Whole-study samples: 15 samples
Specimen: Tissue
Reported/interpreted study design: Disease/model vs control Design classification does not establish patient pairs.

Comparison type: Tumor vs normal
Contributors: Yang Y, Xia L, Shu Y, Wu X
Contact name: Yun Yang
Submission date: 2023-03-20
Last update: 2023-09-20
Organization: West China Hospital, Sichuan University
Department: Colorectal Cancer Center, Department of General Surgery
Public date: 2023-03-28
Experiment types: Expression profiling by high throughput sequencing
Platforms: GPL20795 HiSeq X Ten (Homo sapiens)
Series type: Series
SubSeries: Not available
BioProject: PRJNA946747

Summary

To use surgical resection specimens of the intact bowel wall from inflammatory bowel disease (IBD) patients and perform RNA-seq, bioinformatics analysis, and validation by quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC) to explore the subtle differences between Crohn's disease (CD) and ulcerative colitis (UC), with predominant focus on the smooth muscle cells (SMCs) and enteric autonomic nervous system (ANS).

Overall design

The intact colon specimens from IBD surgical patients were divided based on their inflammatory status into inflamed (6 iCD, 6 iUC) and non-inflamed (6 niBD: 3 niCD+3 niUC) groups

Source Evidence

4 sources

Source	Contribution	Status
GEO	Original dataset metadata, sample metadata, source links, and GEO data availability flags. Sample records 15 GSM samples	Primary source
recount3	Planned trusted source for processed count availability.	No match found
Expression Atlas	Planned source for curated expression experiment links.	No match found
PubMed	Primary GEO citations and related PubMed articles that mention this dataset. 1 linked publication 1 DOI Primary publication Transcriptome profiling of intact bowel wall reveals that PDE1A and SEMA3D are possible markers with roles in enteric smooth muscle apoptosis, proliferative disorders, and dysautonomia in Crohn's disease. Frontiers in genetics, 2023 PubMed DOI	Available

Metadata Quality Components

Persisted metadata quality

100 pts

Clarity: 100%
Weight: 100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Ready after review

97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Standard analyst review

Proceed only after the analyst confirms grouping, exclusions, and source files.

By Siftome standards, no expert review was triggered.

Why This Is Ranked Here

Tumor vs normal

Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

Disease context Crohn's disease, colorectal cancer, inflammatory bowel disease, ulcerative colitis Disease context came from Normalization rules.
Likely case group Crohn's disease 10 samples
Likely control group Non-inflamed tissue 5 samples

Ranking Facts

Supporting evidence

Comparison: Disease/model vs control. Specimen: Tissue. Comparison suitability: 0%.
Prioritized assay: bulk RNA-seq is the active assay expectation.
Interpreted disease metadata: Crohn's disease, Inflammatory bowel disease, Ulcerative colitis.
Processed data is available for downstream review.
External evidence: PubMed links 1 publication; 1 DOI available: PMID 37727374.
Publication context: Transcriptome profiling of intact bowel wall reveals that PDE1A and SEMA3D are possible markers with roles in enteric smooth muscle apoptosis, proliferative disorders, and dysautonomia in Crohn's disease.. Frontiers in genetics, 2023. PMID 37727374. DOI 10.3389/fgene.2023.1194882.

Cautions

Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
Overall score capped because comparison suitability is weak for the selected search intent.
Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Multiple disease or phenotype arms were detected. The displayed grouping summarizes the full dataset; select the requested disease-specific contrast before analysis.

Normalized Fields

52 fields

Field Value Source Derived by Confidence Evidence Reason

anatomical_source colon GSM7106751 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106752 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106753 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106754 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106755 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106756 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106757 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106758 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106759 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106760 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106761 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106762 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106763 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106764 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

anatomical_source colon GSM7106765 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colon tissue: colon, intact bowel wall sample-anatomical-source-v1 sample-local anatomical source

assay_type bulk RNA-seq GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence bulk rna-seq dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... keyword match keyword match: bulk rna-seq

disease Crohn's disease GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease colorectal cancer GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence colorectal cancer dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... controlled vocabulary controlled vocabulary disease match: colorectal cancer

disease inflammatory bowel disease GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflammatory bowel disease dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... controlled vocabulary controlled vocabulary disease match: inflammatory bowel disease

disease ulcerative colitis GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease Crohn's disease GSM7106751 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease iCD1, male, 32 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM7106752 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease iCD2, male, 23 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM7106753 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease iCD3, male, 24 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM7106754 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease iCD5, male, 46 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease Crohn's disease GSM7106755 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence Crohn's disease iCD6, male, 25 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary disease match: Crohn's disease

disease ulcerative colitis GSM7106761 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis iUC1, male, 65 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM7106762 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis iUC2, male, 75 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM7106763 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis iUC3, male, 67 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM7106764 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis iUC4, male, 56 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary disease match: ulcerative colitis

disease ulcerative colitis GSM7106765 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence ulcerative colitis iUC5, male, 67 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary disease match: ulcerative colitis

organism Homo sapiens GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence homo sapiens dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... keyword match keyword match: homo sapiens

sample_type non-inflamed tissue GSM7106756 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence non-inflamed niBD1, male, 32 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary sample type match: non-inflamed

sample_type non-inflamed tissue GSM7106757 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence non-inflamed niBD2, male, 23 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary sample type match: non-inflamed

sample_type non-inflamed tissue GSM7106758 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence non-inflamed niBD3, male, 24 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary sample type match: non-inflamed

sample_type non-inflamed tissue GSM7106759 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence non-inflamed niBD4, male, 56 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary sample type match: non-inflamed

sample_type non-inflamed tissue GSM7106760 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence non-inflamed niBD5, male, 67 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary sample type match: non-inflamed

tissue colon GSE227747 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon dataset_accession: GSE227747 dataset_title: Transcriptome Profiling of Intact Bowel Wall Reveals that PDE1A and SEMA3D are Possible Markers with Roles in Enteric Smooth Muscle A... controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106751 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iCD1, male, 32 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106752 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iCD2, male, 23 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106753 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iCD3, male, 24 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106754 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iCD5, male, 46 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106755 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iCD6, male, 25 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: Crohn’s disease controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106756 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon niBD1, male, 32 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106757 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon niBD2, male, 23 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106758 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon niBD3, male, 24 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106759 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon niBD4, male, 56 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106760 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon niBD5, male, 67 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: non-inflamed colon controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106761 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iUC1, male, 65 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106762 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iUC2, male, 75 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106763 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iUC3, male, 67 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106764 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iUC4, male, 56 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary tissue match: colon

tissue colon GSM7106765 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence colon iUC5, male, 67 years old colon, intact bowel wall tissue: colon, intact bowel wall; disease state: ulcerative colitis controlled vocabulary controlled vocabulary tissue match: colon

Sample Group Preview

15 rows shown Show Hide

Study totals: Case 10 | Control 5 | Unassigned 0 | Excluded 0 | Ambiguous 0 15 rows shown

Group	Role	Accession	Title	Source / characteristics	Reason
Crohn's disease	Case	GSM7106751	iCD1, male, 32 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Crohn’s disease	Case marker detected.
Crohn's disease	Case	GSM7106752	iCD2, male, 23 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Crohn’s disease	Case marker detected.
Crohn's disease	Case	GSM7106753	iCD3, male, 24 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Crohn’s disease	Case marker detected.
Crohn's disease	Case	GSM7106754	iCD5, male, 46 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Crohn’s disease	Case marker detected.
Crohn's disease	Case	GSM7106755	iCD6, male, 25 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Crohn’s disease	Case marker detected.
Ulcerative colitis	Case	GSM7106761	iUC1, male, 65 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Ulcerative colitis	Case marker detected.
Ulcerative colitis	Case	GSM7106762	iUC2, male, 75 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Ulcerative colitis	Case marker detected.
Ulcerative colitis	Case	GSM7106763	iUC3, male, 67 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Ulcerative colitis	Case marker detected.
Ulcerative colitis	Case	GSM7106764	iUC4, male, 56 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Ulcerative colitis	Case marker detected.
Ulcerative colitis	Case	GSM7106765	iUC5, male, 67 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Ulcerative colitis	Case marker detected.
Non-inflamed tissue	Control	GSM7106756	NiBD1, male, 32 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Non-inflamed colon	Control marker detected.
Non-inflamed tissue	Control	GSM7106757	NiBD2, male, 23 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Non-inflamed colon	Control marker detected.
Non-inflamed tissue	Control	GSM7106758	NiBD3, male, 24 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Non-inflamed colon	Control marker detected.
Non-inflamed tissue	Control	GSM7106759	NiBD4, male, 56 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Non-inflamed colon	Control marker detected.
Non-inflamed tissue	Control	GSM7106760	NiBD5, male, 67 years old	Colon, intact bowel wall Tissue: Colon, intact bowel wall; Disease state: Non-inflamed colon	Control marker detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.

Summary

Overall design

Source Evidence

Primary publication

Metadata Quality Components

Analysis Readiness

Blockers

Next Steps

Analysis Preparation Checklist

Bioinformatician Review

Why This Is Ranked Here

Applied Review Decisions

Derived Classifications

Ranking Facts

Supporting evidence

Cautions

Dataset Warnings

Normalized Fields

Sample Group Preview

Use as Discovery Cohort