Exon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

26 case / 13 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source: GEO
Assay: microarray
Organism: Homo sapiens
Whole-study samples: 39 samples
Specimen: Tissue
Reported/interpreted study design: Disease/model vs control Design classification does not establish patient pairs.

Comparison type: Tumor vs normal
Contributors: Plager DA, Kita H
Contact name: Douglas A Plager
Submission date: 2010-08-10
Last update: 2019-02-18
Organization: Mayo Clinic Rochester
Department: Dermatology
Public date: 2010-08-12
Experiment types: Expression profiling by array
Platforms: GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Series type: Series
SubSeries: Not available
BioProject: PRJNA131817

Summary

Asthmatic chronic rhinosinusitis with nasal polyps (aCRSwNP) is a common disruptive eosinophilic disease. Therefore, we sought to identify gene expression changes in nasosinus inflamed mucosa and adjacent polyp tissue from subjects with aCRSwNP.

Overall design

Twelve asthmatic chronic rhinosinusitis (aCRS) subjects (11 with nasal polyps; aCRSwNP) provided inflamed nasosinus mucosa (11 samples) and adjacent polyp (10 samples) or a small mixed mucosa and polyp specimen (1 sample) (thus, 22 samples overall). Inflamed mucosa or polyp was from the middle meatus or anterior ethmoid cavity. As control samples, nasosinus tissue was collected from the inferior turbinate or uncinate process from normal or rhinitis subjects without nasal polyps (n=17); 4 had physician-diagnosed allergic rhinitis (AR), 2 had suspected AR, 1 had suspected vasomotor rhinitis, and 10 had no signs of nasosinus disease, allergy, or atopy. All 4 AR subjects chose to donate tissue outside of their known allergy season(s).

Source Evidence

4 sources

Source	Contribution	Status
GEO	Original dataset metadata, sample metadata, source links, and GEO data availability flags. Sample records 39 GSM samples	Primary source
recount3	Planned trusted source for processed count availability.	No match found
Expression Atlas	Planned source for curated expression experiment links.	No match found
PubMed	Primary GEO citations and related PubMed articles that mention this dataset. 6 linked publications 5 DOIs Primary publication Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PloS one, 2010 PubMed DOI Related publications Comprehensive profiling of the heterogeneity of molecular endotypic traits in chronic rhinosinusitis. Human immunology, 2025 PubMed DOI The characterization and validation of regulated cell death-related genes in chronic rhinosinusitis with nasal polyps. International immunopharmacology, 2025 PubMed DOI Transcriptomic Signatures and Functional Network Analysis of Chronic Rhinosinusitis With Nasal Polyps. Frontiers in genetics, 2021 PubMed DOI Identification of key genes and pathways in chronic rhinosinusitis with nasal polyps and asthma comorbidity using bioinformatics approaches. Frontiers in immunology, 2022 PubMed DOI Bioinformatics analysis and verification of key candidate genes influencing the pathogenesis of chronic rhinosinusitis with nasal polyps. American journal of translational research, 2023 PubMed	Available

Metadata Quality Components

Persisted metadata quality

85 pts

Clarity: 85%
Weight: 100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Ready after review

97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal

Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
Disease context Asthma, inflammatory bowel disease Disease context came from Normalization rules.
Likely case group Allergic rhinitis 26 samples
Likely control group Healthy control 13 samples

Intent Interpretation

Downgrade or exclusion reason Downgraded assay: microarray cohorts are separated from the RNA-seq intent. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

Comparison: Disease/model vs control. Specimen: Tissue. Comparison suitability: 0%.
Interpreted disease metadata: Asthma, Inflammatory bowel disease.
Processed data is available for downstream review.
External evidence: PubMed links 6 publications; 5 DOIs available: PMID 20625511, PMID 33603773, PMID 36059464, PMID 36915741, PMID 39986126.
Publication context: Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.. PloS one, 2010. PMID 20625511. DOI 10.1371/journal.pone.0011450.
Publication context: Transcriptomic Signatures and Functional Network Analysis of Chronic Rhinosinusitis With Nasal Polyps.. Frontiers in genetics, 2021. PMID 33603773. DOI 10.3389/fgene.2021.609754.
Publication context: Identification of key genes and pathways in chronic rhinosinusitis with nasal polyps and asthma comorbidity using bioinformatics approaches.. Frontiers in immunology, 2022. PMID 36059464. DOI 10.3389/fimmu.2022.941547.
Publication context: 3 additional linked PubMed publications are available.

Cautions

Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
Missing or unclear metadata. Tissue clarity - Tissue metadata was not normalized.
Overall score capped because comparison suitability is weak for the selected search intent.
Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Microarray expression context was detected; compare separately from RNA-seq cohorts.
Multiple disease or phenotype arms were detected. The displayed grouping summarizes the full dataset; select the requested disease-specific contrast before analysis.
Microarray datasets are downgraded in the patient-tissue tumor-normal intent unless secondary assays are explicitly enabled.

Normalized Fields

61 fields

Field Value Source Derived by Confidence Evidence Reason

assay_type microarray GSE23552 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence microarray dataset_accession: GSE23552 dataset_title: Exon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps organism: Homo sapiens assay_type: microarray processed_data... keyword match keyword match: microarray

disease asthma GSE23552 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic dataset_accession: GSE23552 dataset_title: Exon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps organism: Homo sapiens assay_type: microarray processed_data... controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSE23552 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa dataset_accession: GSE23552 dataset_title: Exon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps organism: Homo sapiens assay_type: microarray processed_data... controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577732 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm10 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577732 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm10 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577733 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm1 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577733 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm1 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577734 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa-Polyp_aCRSm12 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: mucosa-polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577736 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm6 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577736 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm6 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577737 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp5 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577738 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp10 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577741 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm3 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577741 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm3 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577742 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp7 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577743 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm11 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577743 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm11 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577744 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp11 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577747 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm7 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577747 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm7 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577748 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp3 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577753 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm8 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577753 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm8 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577754 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp8 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577755 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp4 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577758 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm9 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577758 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm9 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577759 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp9 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577760 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm2 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis (no nasal polyps); tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577760 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm2 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis (no nasal polyps); tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577761 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm4 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577761 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm4 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577762 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalMucosa(inflamed)_aCRSm5 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: asthmatic

disease inflammatory bowel disease GSM577762 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence inflamed mucosa NasalMucosa(inflamed)_aCRSm5 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary disease match: inflamed mucosa

disease asthma GSM577763 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp1 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

disease asthma GSM577764 Runtime Siftome inference UNRESOLVED / UNREVIEWED medium confidence asthmatic NasalPolyp_aCRSp6 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: polyp controlled vocabulary controlled vocabulary disease match: asthmatic

organism Homo sapiens GSE23552 Runtime Siftome inference UNRESOLVED / UNREVIEWED high confidence homo sapiens dataset_accession: GSE23552 dataset_title: Exon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps organism: Homo sapiens assay_type: microarray processed_data... keyword match keyword match: homo sapiens

sample_type normal tissue GSM577728 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal13 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type normal tissue GSM577729 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal1 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type normal tissue GSM577731 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal2 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type inflamed tissue GSM577732 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm10 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type inflamed tissue GSM577733 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm1 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type normal tissue GSM577735 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal9 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type inflamed tissue GSM577736 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm6 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type normal tissue GSM577739 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal10 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type inflamed tissue GSM577741 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm3 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type inflamed tissue GSM577743 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm11 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type normal tissue GSM577745 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal11 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type normal tissue GSM577746 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal6 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type inflamed tissue GSM577747 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm7 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type normal tissue GSM577749 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal7 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type normal tissue GSM577750 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal8 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type normal tissue GSM577751 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal12 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type inflamed tissue GSM577753 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm8 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type normal tissue GSM577756 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal5 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type inflamed tissue GSM577758 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm9 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type inflamed tissue GSM577760 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm2 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis (no nasal polyps); tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type inflamed tissue GSM577761 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm4 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type inflamed tissue GSM577762 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence inflamed NasalMucosa(inflamed)_aCRSm5 nasosinus tissue disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; tissue: inflamed mucosa controlled vocabulary controlled vocabulary sample type match: inflamed

sample_type normal tissue GSM577765 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal3 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

sample_type normal tissue GSM577766 Runtime Siftome inference UNRESOLVED / UNREVIEWED low confidence normal NasalMucosa_Normal4 nasosinus tissue disease state: Normal; tissue: mucosa controlled vocabulary controlled vocabulary sample type match: normal

Sample Group Preview

39 rows shown Show Hide

Study totals: Case 26 | Control 13 | Unassigned 0 | Excluded 0 | Ambiguous 0 39 rows shown

Group	Role	Accession	Title	Source / characteristics	Reason
Allergic rhinitis	Case	GSM577730	NasalMucosa_AR1	Nasosinus tissue Disease state: Allergic Rhinitis; Tissue: Mucosa	Explicit characteristic comparison arm detected.
Inflamed tissue	Case	GSM577732	NasalMucosa(inflamed)_aCRSm10	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Inflamed tissue	Case	GSM577733	NasalMucosa(inflamed)_aCRSm1	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577734	NasalMucosa-Polyp_aCRSm12	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Mucosa-polyp	Case marker detected.
Inflamed tissue	Case	GSM577736	NasalMucosa(inflamed)_aCRSm6	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577737	NasalPolyp_aCRSp5	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Asthma	Case	GSM577738	NasalPolyp_aCRSp10	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Allergic rhinitis	Case	GSM577740	NasalMucosa_AR4	Nasosinus tissue Disease state: Allergic Rhinitis; Tissue: Mucosa	Explicit characteristic comparison arm detected.
Inflamed tissue	Case	GSM577741	NasalMucosa(inflamed)_aCRSm3	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577742	NasalPolyp_aCRSp7	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Inflamed tissue	Case	GSM577743	NasalMucosa(inflamed)_aCRSm11	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577744	NasalPolyp_aCRSp11	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Inflamed tissue	Case	GSM577747	NasalMucosa(inflamed)_aCRSm7	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577748	NasalPolyp_aCRSp3	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Allergic rhinitis	Case	GSM577752	NasalMucosa_AR2	Nasosinus tissue Disease state: Allergic Rhinitis; Tissue: Mucosa	Explicit characteristic comparison arm detected.
Inflamed tissue	Case	GSM577753	NasalMucosa(inflamed)_aCRSm8	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577754	NasalPolyp_aCRSp8	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Asthma	Case	GSM577755	NasalPolyp_aCRSp4	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Allergic rhinitis	Case	GSM577757	NasalMucosa_AR3	Nasosinus tissue Disease state: Allergic Rhinitis; Tissue: Mucosa	Explicit characteristic comparison arm detected.
Inflamed tissue	Case	GSM577758	NasalMucosa(inflamed)_aCRSm9	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577759	NasalPolyp_aCRSp9	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Inflamed tissue	Case	GSM577760	NasalMucosa(inflamed)_aCRSm2	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis (no nasal polyps); Tissue: Inflamed mucosa	Case marker detected.
Inflamed tissue	Case	GSM577761	NasalMucosa(inflamed)_aCRSm4	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Inflamed tissue	Case	GSM577762	NasalMucosa(inflamed)_aCRSm5	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Inflamed mucosa	Case marker detected.
Asthma	Case	GSM577763	NasalPolyp_aCRSp1	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Asthma	Case	GSM577764	NasalPolyp_aCRSp6	Nasosinus tissue Disease state: Asthmatic Chronic Rhinosinusitis with Nasal Polyps; Tissue: Polyp	Case marker detected.
Healthy control	Control	GSM577728	NasalMucosa_Normal13	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577729	NasalMucosa_Normal1	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577731	NasalMucosa_Normal2	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577735	NasalMucosa_Normal9	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577739	NasalMucosa_Normal10	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577745	NasalMucosa_Normal11	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577746	NasalMucosa_Normal6	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577749	NasalMucosa_Normal7	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577750	NasalMucosa_Normal8	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577751	NasalMucosa_Normal12	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577756	NasalMucosa_Normal5	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577765	NasalMucosa_Normal3	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.
Healthy control	Control	GSM577766	NasalMucosa_Normal4	Nasosinus tissue Disease state: Normal; Tissue: Mucosa	Sample-local control marker detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.

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Use as Discovery Cohort