GSE26440

Expression data for derivation of septic shock subgroups

Whole-study status Exploratory only

Dataset can inform exploration but is not strong enough for primary analysis.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Source
GEO
Assay
microarray
Organism
Homo sapiens
Whole-study samples
130 samples
Specimen
Biofluid
Reported/interpreted study design
Patient biofluid vs healthy control Design classification does not establish patient pairs.
Comparison type
Tumor vs normal
Contributors
Wong HR
Contact name
Hector R Wong
Submission date
2011-01-04
Last update
2019-08-16
Organization
Cincinnati Children's Hospital Medical Center
Department
Pediatrics
Public date
2011-01-13
Experiment types
Expression profiling by array
Platforms
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Series type
Series
SubSeries
Not available
BioProject
PRJNA136823

Summary

Background: Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies. Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through genome-wide expression profiling. Methods: Genome-wide expression profiling was conducted using whole blood-derived RNA from 98 children with septic shock, followed by a series of bioinformatic approaches targeted at subclass discovery and characterization. Results: Three putative subclasses (subclasses A, B, and C) were initially identified based on an empiric, discovery-oriented expression filter and unsupervised hierarchical clustering. Statistical comparison of the 3 putative subclasses (ANOVA, Bonferonni correction, p < 0.05) identified 6,934 differentially regulated genes. K means clustering of these 6,934 genes generated 10 coordinately regulated gene clusters corresponding to multiple signaling and metabolic pathways, all of which were differentially regulated across the 3 subclasses. Leave one out cross validation procedures indentified 100 genes having the strongest predictive values for subclass identification. Forty-four of these 100 genes corresponded to signaling pathways relevant to the adaptive immune system and glucocorticoid receptor signaling, the majority of which were repressed in subclass A patients. Subclass A patients were also characterized by repression of genes corresponding to zinc-related biology. Phenotypic analyses revealed that subclass A patients were younger, had a higher illness severity, and a higher mortality rate than patients in subclasses B and C. Conclusions: Genome-wide expression profiling can identify pediatric septic shock subclasses having clinically relevant phenotypes.

Overall design

Expression data from 98 children with septic shock and 32 normal controls were generated using whole blood-derived RNA samples representing the first 24 hours of admission to the pediatric intensive care unit. The controls were used for normalization. Subsequently, we used the expression data to derive expression-based subclasses of patients using discovery oriented expression and statistical filters, followed by unsupervised hierarchical clustering.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
130 GSM samples
 Primary source
recount3

Planned trusted source for processed count availability.

 No match found
Expression Atlas

Planned source for curated expression experiment links.

 No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

24 linked publications 24 DOIs

Primary publication

  1. Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock. American journal of respiratory and critical care medicine, 2014
  2. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC medicine, 2009
  3. Differential expression of the Nrf2-linked genes in pediatric septic shock. Critical care (London, England), 2015
  4. The influence of developmental age on the early transcriptomic response of children with septic shock. Molecular medicine (Cambridge, Mass.), 2011

Related publications

  1. Comprehensive analysis and experimental validation of BST1 as a novel diagnostic biomarker for pediatric sepsis using multiple machine learning algorithms. European journal of pediatrics, 2025
  2. Identification of Glycolysis-Related Signature and Molecular Subtypes in Child Sepsis Through Machine Learning and Consensus Clustering: Implications for Diagnosis and Therapeutics. Molecular biotechnology, 2026
  3. MAPK14 drives Ferroptosis and immune dysfunction in pediatric Sepsis-induced acute lung injury. Cellular immunology, 2025
  4. Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis. Free radical biology & medicine, 2025
  5. Data-driven analysis that integrates bioinformatics and machine learning uncovers PANoptosis-related diagnostic genes in early pediatric septic shock. Heliyon, 2024
  6. Genetic analysis of diagnostic and therapeutic potential for ferroptosis in postoperative sepsis. International immunopharmacology, 2025
  7. SLC22A4 as a candidate regulator linking immunity and ferroptosis in septic shock. Molecular immunology, 2026
  8. Integrated bioinformatics analysis reveals cytokine dysregulation, pathway alterations, and machine learning identification of diagnostic biomarkers in sepsis. Integrative biology : quantitative biosciences from nano to macro, 2026
  9. Exploring the biomarkers for diagnostic accuracy associated with glycolysis and macrophage polarization in pediatric sepsis and performing mechanistic studies. Medicine, 2025
  10. A diagnostic model for sepsis using an integrated machine learning framework approach and its therapeutic drug discovery. BMC infectious diseases, 2025
  11. Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis. PloS one, 2024
  12. Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance. Journal of inflammation research, 2025
  13. Exploring the Role of Peroxisome-Related Processes and Key Marker Genes in Sepsis: Insights Into Immune Dynamics and Therapeutic Potential. Journal of inflammation research, 2025
  14. Pyroptosis-Related Molecular Clusters and Immune Infiltration in Pediatric Sepsis. Pediatric health, medicine and therapeutics, 2025
  15. Systematic analysis of bacterial lipopolysaccharide-related genes and immune cell infiltration characteristics in pediatric septic shock using integrated bioinformatics and machine learning approaches. Frontiers in bioinformatics, 2026
  16. Identification of FTO as a key m6A demethylase linking immune dysregulation to sepsis pathogenesis. Frontiers in immunology, 2026
  17. Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis. Frontiers in pharmacology, 2025
  18. The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering. Frontiers in pharmacology, 2025
  19. Identification of potential biological targets in sepsis based on random forest and artificial neural network models. Journal of infection in developing countries, 2026
  20. Identification and analysis of exosome-associated signatures in pediatric sepsis by integrated bioinformatics analysis and machine learning. PeerJ, 2026
Available

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Anatomical source metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Analysis Readiness

Review before analysis
85% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

3/15 pts

Unassigned or review-needed samples remain before analysis.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • 32 samples need manual grouping review.

Next Steps

  • Resolve unassigned or review-needed samples in the grouping table.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Needs review

32 review-needed samples and 0 unassigned samples remain.

Resolve ambiguous and unassigned samples before finalizing the contrast.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

One or more samples were flagged for manual review.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal
Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Septic shock Disease context came from Normalization rules.
  • Likely case group Sepsis or systemic inflammatory response 98 samples
  • Likely control group Healthy control 32 samples

Intent Interpretation

  • Downgrade or exclusion reason Downgraded for tissue search because it is a biofluid cohort. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Comparison: Patient biofluid vs healthy control. Specimen: Biofluid. Comparison suitability: 20%.
  • Interpreted disease metadata: Septic shock.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 24 publications; 24 DOIs available: PMID 19624809, PMID 21738952, PMID 24650276, PMID 26376786, PMID 39315170.
  • Publication context: Identification of pediatric septic shock subclasses based on genome-wide expression profiling.. BMC medicine, 2009. PMID 19624809. DOI 10.1186/1741-7015-7-34.
  • Publication context: The influence of developmental age on the early transcriptomic response of children with septic shock.. Molecular medicine (Cambridge, Mass.), 2011. PMID 21738952. DOI 10.2119/molmed.2011.00169.
  • Publication context: Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock.. American journal of respiratory and critical care medicine, 2014. PMID 24650276. DOI 10.1164/rccm.201401-0171OC.
  • Publication context: 21 additional linked PubMed publications are available.

Cautions

  • Downgraded for tissue search because it is a biofluid cohort.
  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Blood, plasma, or serum cohort downgraded because this ranking targets tissue tumor-vs-normal comparisons.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

showing 500 of 556 fields

Sample Group Preview

showing 82 of 130 preview rows Show Hide
Study totals: Case 98 | Control 0 | Unassigned 0 | Excluded 0 | Ambiguous 32 showing 82 of 130 preview rows
Group Role Accession Title Source / characteristics Reason
Sepsis or systemic inflammatory response Case GSM648590 Septic Shock_biological rep1 01-0013 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 9.4; Outcome: Nonsurvivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648591 Septic Shock_biological rep2 01-0014 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 3; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648592 Septic Shock_biological rep3 01-0019 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.1; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648593 Septic Shock_biological rep4 01-0021 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 1.9; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648594 Septic Shock_biological rep5 01-0024 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.8; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648595 Septic Shock_biological rep6 01-0025 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.3; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648596 Septic Shock_biological rep7 01-0026 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 9.1; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648597 Septic Shock_biological rep8 01-0030 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.6; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648598 Septic Shock_biological rep9 01-0033A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.6; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648599 Septic Shock_biological rep10 01-0045A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 8.8; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648600 Septic Shock_biological rep11 01-0049A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.9; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648601 Septic Shock_biological rep12 01-0051A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 4.5; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648602 Septic Shock_biological rep13 01-0052A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648603 Septic Shock_biological rep14 01-0053A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.5; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648604 Septic Shock_biological rep15 01-0064 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.4; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648605 Septic Shock_biological rep16 01-0068 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.1; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648606 Septic Shock_biological rep17 01-0069 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.8; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648607 Septic Shock_biological rep18 01-0071 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.7; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648608 Septic Shock_biological rep19 01-0072 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 6.8; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648609 Septic Shock_biological rep20 01-0073 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 7.1; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648610 Septic Shock_biological rep21 01-0074 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 7.3; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648611 Septic Shock_biological rep22 01-0077 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 4.4; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648612 Septic Shock_biological rep23 01-0078 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.8; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648613 Septic Shock_biological rep24 01-0079 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.3; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648614 Septic Shock_biological rep25 01-0080 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 3; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648615 Septic Shock_biological rep26 01-0007A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 3.7; Outcome: Nonsurvivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648616 Septic Shock_biological rep27 01-0034A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.7; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648617 Septic Shock_biological rep28 01-0036A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.7; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648618 Septic Shock_biological rep29 01-0044A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.1; Outcome: Nonsurvivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648619 Septic Shock_biological rep30 01-0047 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.7; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648620 Septic Shock_biological rep31 01-0058A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648621 Septic Shock_biological rep32 01-0059A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 1.6; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648622 Septic Shock_biological rep33 01-0060A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 1.1; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648623 Septic Shock_biological rep34 01-0061A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 1.9; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648624 Septic Shock_biological rep35 01-0062A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.2; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648625 Septic Shock_biological rep36 05-0007 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 4.2; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648626 Septic Shock_biological rep37 01-0066A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.3; Outcome: Nonsurvivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648627 Septic Shock_biological rep38 01-0070 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 7.2; Outcome: Survivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648628 Septic Shock_biological rep39 01-0086 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0; Outcome: Nonsurvivor; Group: C Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648629 Septic Shock_biological rep40 01-0088 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.8; Outcome: Nonsurvivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648633 Septic Shock_biological rep41 02-0001 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 7.3; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648634 Septic Shock_biological rep42 02-0002A Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 5.7; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648635 Septic Shock_biological rep43 04-0003 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.9; Outcome: Nonsurvivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648636 Septic Shock_biological rep44 04-0005 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 1.6; Outcome: Nonsurvivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648642 Septic Shock_biological rep45 05-0003 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 7.3; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648643 Septic Shock_biological rep46 05-0006 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 2.3; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648644 Septic Shock_biological rep47 05-0008 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 9; Outcome: Survivor; Group: B Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648645 Septic Shock_biological rep48 05-0010 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.2; Outcome: Nonsurvivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648646 Septic Shock_biological rep49 05-0011 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0; Outcome: Survivor; Group: A Explicit sample label case marker detected.
Sepsis or systemic inflammatory response Case GSM648647 Septic Shock_biological rep50 06-0001 Children ≤ 10 years old Tissue: Whole blood; Disease state: Septic shock patient; Age (years): 0.3; Outcome: Survivor; Group: A Explicit sample label case marker detected.
48 additional case samples are hidden from this preview.
Healthy control Ambiguous GSM648630 Control_biological rep1 01-0104 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 3.3; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648631 Control_biological rep2 01-0105 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.9; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648632 Control_biological rep3 01-0106 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 5.3; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648637 Control_biological rep4 04-0010C Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648638 Control_biological rep5 04-0010 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648639 Control_biological rep6 04-0011C Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 2.9; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648640 Control_biological rep7 04-0011 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 2.9; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648641 Control_biological rep8 04-0015 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648668 Control_biological rep9 11-0008 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 3.7; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648669 Control_biological rep10 11-0009 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.7; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648671 Control_biological rep11 11-0011 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.9; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648672 Control_biological rep12 11-0012 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648673 Control_biological rep13 11-0013 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 6.8; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648674 Control_biological rep14 11-0014 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648676 Control_biological rep15 11-0018 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 5.9; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648677 Control_biological rep16 11-0019 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 9.7; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648678 Control_biological rep17 11-0020 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.2; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648679 Control_biological rep18 11-0027 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.3; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648681 Control_biological rep19 11-0037 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.3; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648686 Control_biological rep20 11-0036 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.2; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648687 Control_biological rep21 11-0052C Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 6; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648688 Control_biological rep22 11-0052 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 6; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648689 Control_biological rep23 11-0077 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 1.9; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648690 Control_biological rep24 11-0078 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0.7; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648691 Control_biological rep25 11-0080 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 1.5; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648692 Control_biological rep26 11-0081 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 3; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648693 Control_biological rep27 11-0082 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 1.2; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648694 Control_biological rep28 11-0083 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 5.1; Outcome: N/a; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648699 Control_biological rep29 15-0001 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 2; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648700 Control_biological rep30 15-0002 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 1.8; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648701 Control_biological rep31 15-0003 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 3.8; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.
Healthy control Ambiguous GSM648703 Control_biological rep32 15-0005 Children ≤ 10 years old Tissue: Whole blood; Disease state: Normal control; Age (years): 0; Outcome: Survivor; Group: N/a ambiguous sample: Ambiguous case/control metadata detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.