GSE277964

Contribution of Stroma to Inflammatory Bowel Disease Progression Revealed in Patient-Derived Human Colon Chips

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

34 case / 32 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function, enhanced inflammation, and increased cancer risk, with symptoms sometimes being exacerbated in women during pregnancy. To investigate the IBD phenotype and disease progression in human intestine, we leveraged organ-on-a-chip (Organ Chip) technology to engineer human Colon Chips lined by homotypic or heterotypic recombinants of intestinal epithelium interfaced with stromal fibroblasts isolated from Healthy or IBD patient-derived colon resections. Chips created with both epithelial and stromal cells from the same ulcerative colitis or Crohn's disease patient showed increased IBD-associated gene pathway activation, elevated pro-inflammatory cytokines, reduced mucus layer thickness, increased intestinal barrier permeability, compared to homotypic Healthy Colon Chips. When heterotypic tissue recombinants were created, the IBD stromal fibroblasts induced the IBD phenotype in healthy epithelium, and healthy colonic fibroblasts partially reduced inflammation in the IBD epithelium. Using this system, we discovered that peristalsis-like mechanical deformations directly impact colon tissue physiology by increasing mucin gene expression, mucus thickness, and barrier permeability in both Healthy and IBD Chips, and that they only stimulate a fibrotic response in IBD Chips. We also found that both inflammation and fibrosis were accentuated in IBD Chips created with cells from a female patient that were exposed to pregnancy-associated hormones. Interestingly, exposure to a carcinogen (N-ethyl-N-nitrosourea) for 3 weeks in vitro induced histological changes and gene duplication in the IBD Chips, but not in the Healthy Chips. These data suggest that the stroma plays a key role in driving inflammation and disease progression in IBD patients and that human Organ Chip technology may represent a new preclinical tool to gain insight into these mechanisms as well as to identify novel diagnostic biomarkers and therapeutics.

Overall design

Comparative gene expression profiling analysis of RNA-seq data for IBD pathology (Crohn's disease and Ulcerative Colitis) modeled in Human Colon Chips.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
66 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

2 linked publications 2 DOIs

Primary publication

  1. Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers. medRxiv : the preprint server for health sciences, 2025
  2. Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers. Research square, 2025
Available

Metadata Quality Components

Analysis Readiness

Ready after review
100% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

10/10 pts

No dataset warnings are present.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

No readiness blockers detected.

Next Steps

  • Verify the proposed sample assignments and case-versus-control comparison against the GEO metadata before using them in DESeq2 or another differential-expression tool.
  • Confirm processed count files and sample identifiers match the exported metadata.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Review the grouping table for biologically meaningful differences that the automated checks may not detect.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Standard analyst review

Proceed only after the analyst confirms grouping, exclusions, and source files.

By Siftome standards, no expert review was triggered.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Disease context Crohn's disease, fibrosis, inflammatory bowel disease, ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Ulcerative colitis 34 samples
  • Likely control group Healthy control 32 samples

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Tissue. Comparison suitability: 0%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Interpreted disease metadata: Crohn's disease, Fibrosis, Inflammatory bowel disease, Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 2 publications; 2 DOIs available: PMID 39677416, PMID 39975910.
  • Publication context: Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers.. medRxiv : the preprint server for health sciences, 2025. PMID 39677416. DOI 10.1101/2024.12.05.24318563.
  • Publication context: Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers.. Research square, 2025. PMID 39975910. DOI 10.21203/rs.3.rs-5627712/v1.

Cautions

  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

No dataset warnings

Normalized Fields

240 fields

Sample Group Preview

66 rows shown
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Study totals: Case 34 | Control 32 | Unassigned 0 | Excluded 0 | Ambiguous 0 66 rows shown
Group Role Accession Title Source / characteristics Reason
Ulcerative colitis Case GSM8535393 Colon fibroblast, IBD, ulcerative colitis, no strain, donor UC3, rep1 Colon Donor: UC3; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535394 Colon fibroblast, IBD, ulcerative colitis, no strain, donor UC3, rep2 Colon Donor: UC3; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535395 Colon fibroblast, IBD, ulcerative colitis, strain, donor UC3, rep2 Colon Donor: UC3; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535396 Colon fibroblast, IBD, ulcerative colitis, strain, donor UC3, rep3 Colon Donor: UC3; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535397 Colon fibroblast, IBD, ulcerative colitis, no strain, donor UC3, rep3 Colon Donor: UC3; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535398 Colon fibroblast, IBD, ulcerative colitis, strain, donor UC3, rep1 Colon Donor: UC3; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535399 Colon epithelium, IBD, ulcerative colitis, strain, donor UC1, rep1 Colon Donor: UC1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535400 Colon fibroblast, IBD, ulcerative colitis, strain, donor UC1, rep1 Colon Donor: UC1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535401 Colon epithelium, IBD, ulcerative colitis, strain, donor UC1, rep2 Colon Donor: UC1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535402 Colon fibroblast, IBD, ulcerative colitis, strain, donor UC1, rep2 Colon Donor: UC1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535403 Colon epithelium, IBD, ulcerative colitis, no strain, donor UC1, rep1 Colon Donor: UC1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535404 Colon fibroblast, IBD, ulcerative colitis, no strain, donor UC1, rep1 Colon Donor: UC1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535405 Colon epithelium, IBD, ulcerative colitis, no strain, donor UC1, rep2 Colon Donor: UC1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535406 Colon fibroblast, IBD, ulcerative colitis, no strain, donor UC1, rep2 Colon Donor: UC1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535407 Colon epithelium, IBD, ulcerative colitis, no strain, donor UC1, rep3 Colon Donor: UC1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535408 Colon fibroblast, IBD, ulcerative colitis, no strain, donor UC1, rep3 Colon Donor: UC1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535421 Colon epithelium, IBD, ulcerative colitis, no strain, donor UC3, rep2 Colon Donor: UC3; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535422 Colon epithelium, IBD, ulcerative colitis, no strain, donor UC3, rep1 Colon Donor: UC3; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535423 Colon epithelium, IBD, ulcerative colitis, no strain, donor UC3, rep3 Colon Donor: UC3; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: No strain Case marker detected.
Ulcerative colitis Case GSM8535424 Colon epithelium, IBD, ulcerative colitis, strain, donor UC3, rep1 Colon Donor: UC3; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535425 Colon epithelium, IBD, ulcerative colitis, strain, donor UC3, rep2 Colon Donor: UC3; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Ulcerative colitis Case GSM8535426 Colon epithelium, IBD, ulcerative colitis, strain, donor UC3, rep3 Colon Donor: UC3; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Ulcerative colitis; Stimulus: Strain Case marker detected.
Crohn's disease Case GSM8535427 Colon epithelium, IBD, crohn's, no strain, donor C1, rep1 Colon Donor: C1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: No strain Case marker detected.
Crohn's disease Case GSM8535428 Colon fibroblast, IBD, crohn's, no strain, donor C1, rep1 Colon Donor: C1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: No strain Case marker detected.
Crohn's disease Case GSM8535429 Colon epithelium, IBD, crohn's, no strain, donor C1, rep2 Colon Donor: C1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: No strain Case marker detected.
Crohn's disease Case GSM8535430 Colon fibroblast, IBD, crohn's, no strain, donor C1, rep2 Colon Donor: C1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: No strain Case marker detected.
Crohn's disease Case GSM8535431 Colon epithelium, IBD, crohn's, no strain, donor C1, rep3 Colon Donor: C1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: No strain Case marker detected.
Crohn's disease Case GSM8535432 Colon fibroblast, IBD, crohn's, no strain, donor C1, rep3 Colon Donor: C1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: No strain Case marker detected.
Crohn's disease Case GSM8535441 Colon epithelium, IBD, crohn's, strain, donor C1, rep1 Colon Donor: C1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: Strain Case marker detected.
Crohn's disease Case GSM8535442 Colon fibroblast, IBD, crohn's, strain, donor C1, rep1 Colon Donor: C1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: Strain Case marker detected.
Crohn's disease Case GSM8535443 Colon epithelium, IBD, crohn's, strain, donor C1, rep2 Colon Donor: C1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: Strain Case marker detected.
Crohn's disease Case GSM8535444 Colon fibroblast, IBD, crohn's, strain, donor C1, rep2 Colon Donor: C1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: Strain Case marker detected.
Crohn's disease Case GSM8535445 Colon epithelium, IBD, crohn's, strain, donor C1, rep3 Colon Donor: C1; Tissue: Colon; Cell type: Epithelial; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: Strain Case marker detected.
Crohn's disease Case GSM8535446 Colon fibroblast, IBD, crohn's, strain, donor C1, rep3 Colon Donor: C1; Tissue: Colon; Cell type: Fibroblast; Phenotype: IBD; Ibd subtype: Crohn's; Stimulus: Strain Case marker detected.
Healthy control Control GSM8535409 Colon epithelium, healthy, strain, donor H3, rep1 Colon Donor: H3; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535410 Colon fibroblast, healthy, strain, donor H3, rep1 Colon Donor: H3; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535411 Colon epithelium, healthy, strain, donor H3, rep2 Colon Donor: H3; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535412 Colon fibroblast, healthy, strain, donor H3, rep2 Colon Donor: H3; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535413 Colon epithelium, healthy, strain, donor H3, rep3 Colon Donor: H3; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535414 Colon fibroblast, healthy, strain, donor H3, rep3 Colon Donor: H3; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535415 Colon epithelium, healthy, no strain, donor H3, rep1 Colon Donor: H3; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535416 Colon fibroblast, healthy, no strain, donor H3, rep1 Colon Donor: H3; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535417 Colon epithelium, healthy, no strain, donor H3, rep2 Colon Donor: H3; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535418 Colon fibroblast, healthy, no strain, donor H3, rep2 Colon Donor: H3; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535419 Colon epithelium, healthy, no strain, donor H3, rep3 Colon Donor: H3; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535420 Colon fibroblast, healthy, no strain, donor H3, rep3 Colon Donor: H3; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535433 Colon epithelium, healthy, no strain, donor H1, rep1 Colon Donor: H1; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535434 Colon fibroblast, healthy, no strain, donor H1, rep1 Colon Donor: H1; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535435 Colon epithelium, healthy, no strain, donor H1, rep2 Colon Donor: H1; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535436 Colon fibroblast, healthy, no strain, donor H1, rep2 Colon Donor: H1; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535437 Colon epithelium, healthy, no strain, donor H2, rep1 Colon Donor: H2; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535438 Colon fibroblast, healthy, no strain, donor H2, rep1 Colon Donor: H2; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535439 Colon epithelium, healthy, no strain, donor H2, rep2 Colon Donor: H2; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535440 Colon fibroblast, healthy, no strain, donor H2, rep2 Colon Donor: H2; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: No strain Sample-local control marker detected.
Healthy control Control GSM8535447 Colon epithelium, healthy, strain, donor H1, rep1 Colon Donor: H1; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535448 Colon fibroblast, healthy, strain, donor H1, rep1 Colon Donor: H1; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535449 Colon epithelium, healthy, strain, donor H1, rep2 Colon Donor: H1; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535450 Colon fibroblast, healthy, strain, donor H1, rep2 Colon Donor: H1; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535451 Colon epithelium, healthy, strain, donor H1, rep3 Colon Donor: H1; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535452 Colon fibroblast, healthy, strain, donor H1, rep3 Colon Donor: H1; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535453 Colon epithelium, healthy, strain, donor H2, rep1 Colon Donor: H2; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535454 Colon fibroblast, healthy, strain, donor H2, rep1 Colon Donor: H2; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535455 Colon epithelium, healthy, strain, donor H2, rep2 Colon Donor: H2; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535456 Colon fibroblast, healthy, strain, donor H2, rep2 Colon Donor: H2; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535457 Colon epithelium, healthy, strain, donor H2, rep3 Colon Donor: H2; Tissue: Colon; Cell type: Epithelial; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.
Healthy control Control GSM8535458 Colon fibroblast, healthy, strain, donor H2, rep3 Colon Donor: H2; Tissue: Colon; Cell type: Fibroblast; Phenotype: Healthy; Ibd subtype: N/A; Stimulus: Strain Sample-local control marker detected.

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