Matching samples

GSE42296 · Distinct, non-overlapping gene panels of peripheral blood gene expression predict response to infliximab therapy in rheumatoid arthritis and Crohn's disease

Download matching samples CSV
Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

The CSV contains only the confirmed cases and controls below. Excluded and uncertain samples are shown for review and are not exported.

These are sample eligibility decisions from the current indexed metadata. Study-level search filters and minimum sample counts do not establish expression quality or analysis readiness.

Included samples (0)

No samples meet the selected requirements. The CSV contains its column headers only.

Uncertain samples (0)

These samples need more evidence before they can be counted. This includes samples without a confirmed case/control role.

No uncertain samples.

Excluded samples (78)

GSM1037296

Excluded

Before treatment (week 0) IBDB14

Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

Requirements and decision evidence
  • organism: Homo sapiens — Insufficient evidence
    • The required value is not reported.
    • assay type: bulk RNA-seq — Insufficient evidence
      • The required value is not reported.
      • specimen category: Tissue or biopsy — Does not meet requirement
        • The reported value differs from the selected requirement.
        • Before treatment (week 0) IBDB14 PBMC cell type: PBMC; subject: Patient 1; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
        • Supported by the indexed evidence.
        • specimen category excludes: Biofluid — Does not meet requirement
          • The reported value differs from the selected requirement.
          • Before treatment (week 0) IBDB14 PBMC cell type: PBMC; subject: Patient 1; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
        Source metadata
        Source name
        PBMC
        Characteristics
        cell type: PBMC; subject: Patient 1; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
        Description
        Not reported
        Indexed organism evidence
        INFERRED · PARENT_INHERITED: Not reported
        Indexed assay evidence
        INFERRED · PARENT_INHERITED: Not reported
        Source
        GEO
        Original indexed metadata
        sample_accession: GSM1037296
        sample_title: Before treatment (week 0) IBDB14
        source_name: PBMC
        characteristics: cell type: PBMC; subject: Patient 1; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

        GSM1037297

        Excluded

        Before treatment (week 0) IBDB17

        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

        Requirements and decision evidence
        • organism: Homo sapiens — Insufficient evidence
          • The required value is not reported.
          • assay type: bulk RNA-seq — Insufficient evidence
            • The required value is not reported.
            • specimen category: Tissue or biopsy — Does not meet requirement
              • The reported value differs from the selected requirement.
              • Before treatment (week 0) IBDB17 PBMC cell type: PBMC; subject: Patient 2; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
              • Supported by the indexed evidence.
              • specimen category excludes: Biofluid — Does not meet requirement
                • The reported value differs from the selected requirement.
                • Before treatment (week 0) IBDB17 PBMC cell type: PBMC; subject: Patient 2; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
              Source metadata
              Source name
              PBMC
              Characteristics
              cell type: PBMC; subject: Patient 2; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
              Description
              Not reported
              Indexed organism evidence
              INFERRED · PARENT_INHERITED: Not reported
              Indexed assay evidence
              INFERRED · PARENT_INHERITED: Not reported
              Source
              GEO
              Original indexed metadata
              sample_accession: GSM1037297
              sample_title: Before treatment (week 0) IBDB17
              source_name: PBMC
              characteristics: cell type: PBMC; subject: Patient 2; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

              GSM1037298

              Excluded

              Before treatment (week 0) IBDB18

              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

              Requirements and decision evidence
              • organism: Homo sapiens — Insufficient evidence
                • The required value is not reported.
                • assay type: bulk RNA-seq — Insufficient evidence
                  • The required value is not reported.
                  • specimen category: Tissue or biopsy — Does not meet requirement
                    • The reported value differs from the selected requirement.
                    • Before treatment (week 0) IBDB18 PBMC cell type: PBMC; subject: Patient 3; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                    • Supported by the indexed evidence.
                    • specimen category excludes: Biofluid — Does not meet requirement
                      • The reported value differs from the selected requirement.
                      • Before treatment (week 0) IBDB18 PBMC cell type: PBMC; subject: Patient 3; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                    Source metadata
                    Source name
                    PBMC
                    Characteristics
                    cell type: PBMC; subject: Patient 3; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                    Description
                    Not reported
                    Indexed organism evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Indexed assay evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Source
                    GEO
                    Original indexed metadata
                    sample_accession: GSM1037298
                    sample_title: Before treatment (week 0) IBDB18
                    source_name: PBMC
                    characteristics: cell type: PBMC; subject: Patient 3; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                    GSM1037299

                    Excluded

                    Before treatment (week 0) IBDB22

                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                    Requirements and decision evidence
                    • organism: Homo sapiens — Insufficient evidence
                      • The required value is not reported.
                      • assay type: bulk RNA-seq — Insufficient evidence
                        • The required value is not reported.
                        • specimen category: Tissue or biopsy — Does not meet requirement
                          • The reported value differs from the selected requirement.
                          • Before treatment (week 0) IBDB22 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                          • Supported by the indexed evidence.
                          • specimen category excludes: Biofluid — Does not meet requirement
                            • The reported value differs from the selected requirement.
                            • Before treatment (week 0) IBDB22 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                          Source metadata
                          Source name
                          PBMC
                          Characteristics
                          cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                          Description
                          Not reported
                          Indexed organism evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Indexed assay evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Source
                          GEO
                          Original indexed metadata
                          sample_accession: GSM1037299
                          sample_title: Before treatment (week 0) IBDB22
                          source_name: PBMC
                          characteristics: cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                          GSM1037300

                          Excluded

                          Before treatment (week 0) IBDB27

                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                          Requirements and decision evidence
                          • organism: Homo sapiens — Insufficient evidence
                            • The required value is not reported.
                            • assay type: bulk RNA-seq — Insufficient evidence
                              • The required value is not reported.
                              • specimen category: Tissue or biopsy — Does not meet requirement
                                • The reported value differs from the selected requirement.
                                • Before treatment (week 0) IBDB27 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                • Supported by the indexed evidence.
                                • specimen category excludes: Biofluid — Does not meet requirement
                                  • The reported value differs from the selected requirement.
                                  • Before treatment (week 0) IBDB27 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                Source metadata
                                Source name
                                PBMC
                                Characteristics
                                cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                Description
                                Not reported
                                Indexed organism evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Indexed assay evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Source
                                GEO
                                Original indexed metadata
                                sample_accession: GSM1037300
                                sample_title: Before treatment (week 0) IBDB27
                                source_name: PBMC
                                characteristics: cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                GSM1037301

                                Excluded

                                Before treatment (week 0) IBDB28

                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                Requirements and decision evidence
                                • organism: Homo sapiens — Insufficient evidence
                                  • The required value is not reported.
                                  • assay type: bulk RNA-seq — Insufficient evidence
                                    • The required value is not reported.
                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                      • The reported value differs from the selected requirement.
                                      • Before treatment (week 0) IBDB28 PBMC cell type: PBMC; subject: Patient 6; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                      • Supported by the indexed evidence.
                                      • specimen category excludes: Biofluid — Does not meet requirement
                                        • The reported value differs from the selected requirement.
                                        • Before treatment (week 0) IBDB28 PBMC cell type: PBMC; subject: Patient 6; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                      Source metadata
                                      Source name
                                      PBMC
                                      Characteristics
                                      cell type: PBMC; subject: Patient 6; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                      Description
                                      Not reported
                                      Indexed organism evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Indexed assay evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Source
                                      GEO
                                      Original indexed metadata
                                      sample_accession: GSM1037301
                                      sample_title: Before treatment (week 0) IBDB28
                                      source_name: PBMC
                                      characteristics: cell type: PBMC; subject: Patient 6; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                      GSM1037302

                                      Excluded

                                      Before treatment (week 0) IBDB33

                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                      Requirements and decision evidence
                                      • organism: Homo sapiens — Insufficient evidence
                                        • The required value is not reported.
                                        • assay type: bulk RNA-seq — Insufficient evidence
                                          • The required value is not reported.
                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                            • The reported value differs from the selected requirement.
                                            • Before treatment (week 0) IBDB33 PBMC cell type: PBMC; subject: Patient 7; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                            • Supported by the indexed evidence.
                                            • specimen category excludes: Biofluid — Does not meet requirement
                                              • The reported value differs from the selected requirement.
                                              • Before treatment (week 0) IBDB33 PBMC cell type: PBMC; subject: Patient 7; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                            Source metadata
                                            Source name
                                            PBMC
                                            Characteristics
                                            cell type: PBMC; subject: Patient 7; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                            Description
                                            Not reported
                                            Indexed organism evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Indexed assay evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Source
                                            GEO
                                            Original indexed metadata
                                            sample_accession: GSM1037302
                                            sample_title: Before treatment (week 0) IBDB33
                                            source_name: PBMC
                                            characteristics: cell type: PBMC; subject: Patient 7; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                            GSM1037303

                                            Excluded

                                            Before treatment (week 0) IBDB34

                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                            Requirements and decision evidence
                                            • organism: Homo sapiens — Insufficient evidence
                                              • The required value is not reported.
                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                • The required value is not reported.
                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                  • The reported value differs from the selected requirement.
                                                  • Before treatment (week 0) IBDB34 PBMC cell type: PBMC; subject: Patient 8; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                  • Supported by the indexed evidence.
                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                    • The reported value differs from the selected requirement.
                                                    • Before treatment (week 0) IBDB34 PBMC cell type: PBMC; subject: Patient 8; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                  Source metadata
                                                  Source name
                                                  PBMC
                                                  Characteristics
                                                  cell type: PBMC; subject: Patient 8; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                  Description
                                                  Not reported
                                                  Indexed organism evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Indexed assay evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Source
                                                  GEO
                                                  Original indexed metadata
                                                  sample_accession: GSM1037303
                                                  sample_title: Before treatment (week 0) IBDB34
                                                  source_name: PBMC
                                                  characteristics: cell type: PBMC; subject: Patient 8; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                  GSM1037304

                                                  Excluded

                                                  Before treatment (week 0) IBDB37

                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                  Requirements and decision evidence
                                                  • organism: Homo sapiens — Insufficient evidence
                                                    • The required value is not reported.
                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                      • The required value is not reported.
                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                        • The reported value differs from the selected requirement.
                                                        • Before treatment (week 0) IBDB37 PBMC cell type: PBMC; subject: Patient 9; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                        • Supported by the indexed evidence.
                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                          • The reported value differs from the selected requirement.
                                                          • Before treatment (week 0) IBDB37 PBMC cell type: PBMC; subject: Patient 9; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                        Source metadata
                                                        Source name
                                                        PBMC
                                                        Characteristics
                                                        cell type: PBMC; subject: Patient 9; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                        Description
                                                        Not reported
                                                        Indexed organism evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Indexed assay evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Source
                                                        GEO
                                                        Original indexed metadata
                                                        sample_accession: GSM1037304
                                                        sample_title: Before treatment (week 0) IBDB37
                                                        source_name: PBMC
                                                        characteristics: cell type: PBMC; subject: Patient 9; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                        GSM1037305

                                                        Excluded

                                                        Before treatment (week 0) IBDB40

                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                        Requirements and decision evidence
                                                        • organism: Homo sapiens — Insufficient evidence
                                                          • The required value is not reported.
                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                            • The required value is not reported.
                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                              • The reported value differs from the selected requirement.
                                                              • Before treatment (week 0) IBDB40 PBMC cell type: PBMC; subject: Patient 10; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                              • Supported by the indexed evidence.
                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                • The reported value differs from the selected requirement.
                                                                • Before treatment (week 0) IBDB40 PBMC cell type: PBMC; subject: Patient 10; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                              Source metadata
                                                              Source name
                                                              PBMC
                                                              Characteristics
                                                              cell type: PBMC; subject: Patient 10; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                              Description
                                                              Not reported
                                                              Indexed organism evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Indexed assay evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Source
                                                              GEO
                                                              Original indexed metadata
                                                              sample_accession: GSM1037305
                                                              sample_title: Before treatment (week 0) IBDB40
                                                              source_name: PBMC
                                                              characteristics: cell type: PBMC; subject: Patient 10; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                              GSM1037306

                                                              Excluded

                                                              Before treatment (week 0) IBDB39

                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                              Requirements and decision evidence
                                                              • organism: Homo sapiens — Insufficient evidence
                                                                • The required value is not reported.
                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                  • The required value is not reported.
                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                    • The reported value differs from the selected requirement.
                                                                    • Before treatment (week 0) IBDB39 PBMC cell type: PBMC; subject: Patient 11; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                    • Supported by the indexed evidence.
                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                      • The reported value differs from the selected requirement.
                                                                      • Before treatment (week 0) IBDB39 PBMC cell type: PBMC; subject: Patient 11; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                    Source metadata
                                                                    Source name
                                                                    PBMC
                                                                    Characteristics
                                                                    cell type: PBMC; subject: Patient 11; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                    Description
                                                                    Not reported
                                                                    Indexed organism evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Indexed assay evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Source
                                                                    GEO
                                                                    Original indexed metadata
                                                                    sample_accession: GSM1037306
                                                                    sample_title: Before treatment (week 0) IBDB39
                                                                    source_name: PBMC
                                                                    characteristics: cell type: PBMC; subject: Patient 11; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                    GSM1037307

                                                                    Excluded

                                                                    Before treatment (week 0) IBDB44

                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                    Requirements and decision evidence
                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                        • The required value is not reported.
                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                          • The reported value differs from the selected requirement.
                                                                          • Before treatment (week 0) IBDB44 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                          • Supported by the indexed evidence.
                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                            • The reported value differs from the selected requirement.
                                                                            • Before treatment (week 0) IBDB44 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                          Source metadata
                                                                          Source name
                                                                          PBMC
                                                                          Characteristics
                                                                          cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                          Description
                                                                          Not reported
                                                                          Indexed organism evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Indexed assay evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Source
                                                                          GEO
                                                                          Original indexed metadata
                                                                          sample_accession: GSM1037307
                                                                          sample_title: Before treatment (week 0) IBDB44
                                                                          source_name: PBMC
                                                                          characteristics: cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                          GSM1037308

                                                                          Excluded

                                                                          Before treatment (week 0) IBDB42

                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                          Requirements and decision evidence
                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                              • The required value is not reported.
                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                • The reported value differs from the selected requirement.
                                                                                • Before treatment (week 0) IBDB42 PBMC cell type: PBMC; subject: Patient 13; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                • Supported by the indexed evidence.
                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                  • The reported value differs from the selected requirement.
                                                                                  • Before treatment (week 0) IBDB42 PBMC cell type: PBMC; subject: Patient 13; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                Source metadata
                                                                                Source name
                                                                                PBMC
                                                                                Characteristics
                                                                                cell type: PBMC; subject: Patient 13; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                Description
                                                                                Not reported
                                                                                Indexed organism evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Indexed assay evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Source
                                                                                GEO
                                                                                Original indexed metadata
                                                                                sample_accession: GSM1037308
                                                                                sample_title: Before treatment (week 0) IBDB42
                                                                                source_name: PBMC
                                                                                characteristics: cell type: PBMC; subject: Patient 13; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                GSM1037309

                                                                                Excluded

                                                                                Before treatment (week 0) IBDB41

                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                Requirements and decision evidence
                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                    • The required value is not reported.
                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                      • The reported value differs from the selected requirement.
                                                                                      • Before treatment (week 0) IBDB41 PBMC cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                      • Supported by the indexed evidence.
                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                        • The reported value differs from the selected requirement.
                                                                                        • Before treatment (week 0) IBDB41 PBMC cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                      Source metadata
                                                                                      Source name
                                                                                      PBMC
                                                                                      Characteristics
                                                                                      cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                      Description
                                                                                      Not reported
                                                                                      Indexed organism evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Indexed assay evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Source
                                                                                      GEO
                                                                                      Original indexed metadata
                                                                                      sample_accession: GSM1037309
                                                                                      sample_title: Before treatment (week 0) IBDB41
                                                                                      source_name: PBMC
                                                                                      characteristics: cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                      GSM1037310

                                                                                      Excluded

                                                                                      Before treatment (week 0) IBDB26

                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                      Requirements and decision evidence
                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                          • The required value is not reported.
                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                            • The reported value differs from the selected requirement.
                                                                                            • Before treatment (week 0) IBDB26 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                            • Supported by the indexed evidence.
                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                              • The reported value differs from the selected requirement.
                                                                                              • Before treatment (week 0) IBDB26 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                            Source metadata
                                                                                            Source name
                                                                                            PBMC
                                                                                            Characteristics
                                                                                            cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                            Description
                                                                                            Not reported
                                                                                            Indexed organism evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Indexed assay evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Source
                                                                                            GEO
                                                                                            Original indexed metadata
                                                                                            sample_accession: GSM1037310
                                                                                            sample_title: Before treatment (week 0) IBDB26
                                                                                            source_name: PBMC
                                                                                            characteristics: cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                            GSM1037311

                                                                                            Excluded

                                                                                            Before treatment (week 0) IBDB23

                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                            Requirements and decision evidence
                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                • The required value is not reported.
                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                  • The reported value differs from the selected requirement.
                                                                                                  • Before treatment (week 0) IBDB23 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                  • Supported by the indexed evidence.
                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                    • The reported value differs from the selected requirement.
                                                                                                    • Before treatment (week 0) IBDB23 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                  Source metadata
                                                                                                  Source name
                                                                                                  PBMC
                                                                                                  Characteristics
                                                                                                  cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                  Description
                                                                                                  Not reported
                                                                                                  Indexed organism evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Indexed assay evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Source
                                                                                                  GEO
                                                                                                  Original indexed metadata
                                                                                                  sample_accession: GSM1037311
                                                                                                  sample_title: Before treatment (week 0) IBDB23
                                                                                                  source_name: PBMC
                                                                                                  characteristics: cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                                  GSM1037312

                                                                                                  Excluded

                                                                                                  Before treatment (week 0) IBDB13

                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                  Requirements and decision evidence
                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                      • The required value is not reported.
                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                        • The reported value differs from the selected requirement.
                                                                                                        • Before treatment (week 0) IBDB13 PBMC cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                        • Supported by the indexed evidence.
                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                          • The reported value differs from the selected requirement.
                                                                                                          • Before treatment (week 0) IBDB13 PBMC cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                        Source metadata
                                                                                                        Source name
                                                                                                        PBMC
                                                                                                        Characteristics
                                                                                                        cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                        Description
                                                                                                        Not reported
                                                                                                        Indexed organism evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Indexed assay evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Source
                                                                                                        GEO
                                                                                                        Original indexed metadata
                                                                                                        sample_accession: GSM1037312
                                                                                                        sample_title: Before treatment (week 0) IBDB13
                                                                                                        source_name: PBMC
                                                                                                        characteristics: cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                                        GSM1037313

                                                                                                        Excluded

                                                                                                        Before treatment (week 0) IBDB08

                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                        Requirements and decision evidence
                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                            • The required value is not reported.
                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                              • The reported value differs from the selected requirement.
                                                                                                              • Before treatment (week 0) IBDB08 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                              • Supported by the indexed evidence.
                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                • Before treatment (week 0) IBDB08 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                              Source metadata
                                                                                                              Source name
                                                                                                              PBMC
                                                                                                              Characteristics
                                                                                                              cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                              Description
                                                                                                              Not reported
                                                                                                              Indexed organism evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Indexed assay evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Source
                                                                                                              GEO
                                                                                                              Original indexed metadata
                                                                                                              sample_accession: GSM1037313
                                                                                                              sample_title: Before treatment (week 0) IBDB08
                                                                                                              source_name: PBMC
                                                                                                              characteristics: cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                                              GSM1037314

                                                                                                              Excluded

                                                                                                              Before treatment (week 0) IBDB03

                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                              Requirements and decision evidence
                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                  • The required value is not reported.
                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                    • Before treatment (week 0) IBDB03 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                    • Supported by the indexed evidence.
                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                      • Before treatment (week 0) IBDB03 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                                    Source metadata
                                                                                                                    Source name
                                                                                                                    PBMC
                                                                                                                    Characteristics
                                                                                                                    cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                                    Description
                                                                                                                    Not reported
                                                                                                                    Indexed organism evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Indexed assay evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Source
                                                                                                                    GEO
                                                                                                                    Original indexed metadata
                                                                                                                    sample_accession: GSM1037314
                                                                                                                    sample_title: Before treatment (week 0) IBDB03
                                                                                                                    source_name: PBMC
                                                                                                                    characteristics: cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                                                    GSM1037315

                                                                                                                    Excluded

                                                                                                                    Before treatment (week 0) IBDB01

                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                    Requirements and decision evidence
                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                        • The required value is not reported.
                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                          • Before treatment (week 0) IBDB01 PBMC cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                          • Supported by the indexed evidence.
                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                            • Before treatment (week 0) IBDB01 PBMC cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                                          Source metadata
                                                                                                                          Source name
                                                                                                                          PBMC
                                                                                                                          Characteristics
                                                                                                                          cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease
                                                                                                                          Description
                                                                                                                          Not reported
                                                                                                                          Indexed organism evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Indexed assay evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Source
                                                                                                                          GEO
                                                                                                                          Original indexed metadata
                                                                                                                          sample_accession: GSM1037315
                                                                                                                          sample_title: Before treatment (week 0) IBDB01
                                                                                                                          source_name: PBMC
                                                                                                                          characteristics: cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Crohn's disease

                                                                                                                          GSM1037316

                                                                                                                          Excluded

                                                                                                                          After treatment (week 2) IBDB16

                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                          Requirements and decision evidence
                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                              • The required value is not reported.
                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                • After treatment (week 2) IBDB16 PBMC cell type: PBMC; subject: Patient 1; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                  • After treatment (week 2) IBDB16 PBMC cell type: PBMC; subject: Patient 1; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                Source metadata
                                                                                                                                Source name
                                                                                                                                PBMC
                                                                                                                                Characteristics
                                                                                                                                cell type: PBMC; subject: Patient 1; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                Description
                                                                                                                                Not reported
                                                                                                                                Indexed organism evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Indexed assay evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Source
                                                                                                                                GEO
                                                                                                                                Original indexed metadata
                                                                                                                                sample_accession: GSM1037316
                                                                                                                                sample_title: After treatment (week 2) IBDB16
                                                                                                                                source_name: PBMC
                                                                                                                                characteristics: cell type: PBMC; subject: Patient 1; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                GSM1037317

                                                                                                                                Excluded

                                                                                                                                After treatment (week 2) IBDB19

                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                Requirements and decision evidence
                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                    • The required value is not reported.
                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                      • After treatment (week 2) IBDB19 PBMC cell type: PBMC; subject: Patient 2; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                        • After treatment (week 2) IBDB19 PBMC cell type: PBMC; subject: Patient 2; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                      Source metadata
                                                                                                                                      Source name
                                                                                                                                      PBMC
                                                                                                                                      Characteristics
                                                                                                                                      cell type: PBMC; subject: Patient 2; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                      Description
                                                                                                                                      Not reported
                                                                                                                                      Indexed organism evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Indexed assay evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Source
                                                                                                                                      GEO
                                                                                                                                      Original indexed metadata
                                                                                                                                      sample_accession: GSM1037317
                                                                                                                                      sample_title: After treatment (week 2) IBDB19
                                                                                                                                      source_name: PBMC
                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 2; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                      GSM1037318

                                                                                                                                      Excluded

                                                                                                                                      After treatment (week 2) IBDB21

                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                      Requirements and decision evidence
                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                          • The required value is not reported.
                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                            • After treatment (week 2) IBDB21 PBMC cell type: PBMC; subject: Patient 3; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                              • After treatment (week 2) IBDB21 PBMC cell type: PBMC; subject: Patient 3; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                            Source metadata
                                                                                                                                            Source name
                                                                                                                                            PBMC
                                                                                                                                            Characteristics
                                                                                                                                            cell type: PBMC; subject: Patient 3; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                            Description
                                                                                                                                            Not reported
                                                                                                                                            Indexed organism evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Indexed assay evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Source
                                                                                                                                            GEO
                                                                                                                                            Original indexed metadata
                                                                                                                                            sample_accession: GSM1037318
                                                                                                                                            sample_title: After treatment (week 2) IBDB21
                                                                                                                                            source_name: PBMC
                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 3; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                            GSM1037319

                                                                                                                                            Excluded

                                                                                                                                            After treatment (week 2) IBDB24

                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                            Requirements and decision evidence
                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                • The required value is not reported.
                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                  • After treatment (week 2) IBDB24 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                    • After treatment (week 2) IBDB24 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                  Source metadata
                                                                                                                                                  Source name
                                                                                                                                                  PBMC
                                                                                                                                                  Characteristics
                                                                                                                                                  cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                  Description
                                                                                                                                                  Not reported
                                                                                                                                                  Indexed organism evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Indexed assay evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Source
                                                                                                                                                  GEO
                                                                                                                                                  Original indexed metadata
                                                                                                                                                  sample_accession: GSM1037319
                                                                                                                                                  sample_title: After treatment (week 2) IBDB24
                                                                                                                                                  source_name: PBMC
                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                  GSM1037320

                                                                                                                                                  Excluded

                                                                                                                                                  After treatment (week 2) IBDB29

                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                      • The required value is not reported.
                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                        • After treatment (week 2) IBDB29 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                          • After treatment (week 2) IBDB29 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                        Source metadata
                                                                                                                                                        Source name
                                                                                                                                                        PBMC
                                                                                                                                                        Characteristics
                                                                                                                                                        cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                        Description
                                                                                                                                                        Not reported
                                                                                                                                                        Indexed organism evidence
                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                        Indexed assay evidence
                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                        Source
                                                                                                                                                        GEO
                                                                                                                                                        Original indexed metadata
                                                                                                                                                        sample_accession: GSM1037320
                                                                                                                                                        sample_title: After treatment (week 2) IBDB29
                                                                                                                                                        source_name: PBMC
                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                        GSM1037321

                                                                                                                                                        Excluded

                                                                                                                                                        After treatment (week 2) IBDB30

                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                          • The required value is not reported.
                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                            • The required value is not reported.
                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                              • After treatment (week 2) IBDB30 PBMC cell type: PBMC; subject: Patient 6; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                • After treatment (week 2) IBDB30 PBMC cell type: PBMC; subject: Patient 6; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                              Source metadata
                                                                                                                                                              Source name
                                                                                                                                                              PBMC
                                                                                                                                                              Characteristics
                                                                                                                                                              cell type: PBMC; subject: Patient 6; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                              Description
                                                                                                                                                              Not reported
                                                                                                                                                              Indexed organism evidence
                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                              Indexed assay evidence
                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                              Source
                                                                                                                                                              GEO
                                                                                                                                                              Original indexed metadata
                                                                                                                                                              sample_accession: GSM1037321
                                                                                                                                                              sample_title: After treatment (week 2) IBDB30
                                                                                                                                                              source_name: PBMC
                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 6; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                              GSM1037322

                                                                                                                                                              Excluded

                                                                                                                                                              After treatment (week 2) IBDB35

                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                    • After treatment (week 2) IBDB35 PBMC cell type: PBMC; subject: Patient 7; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                      • After treatment (week 2) IBDB35 PBMC cell type: PBMC; subject: Patient 7; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                    Source metadata
                                                                                                                                                                    Source name
                                                                                                                                                                    PBMC
                                                                                                                                                                    Characteristics
                                                                                                                                                                    cell type: PBMC; subject: Patient 7; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                    Description
                                                                                                                                                                    Not reported
                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                    Source
                                                                                                                                                                    GEO
                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                    sample_accession: GSM1037322
                                                                                                                                                                    sample_title: After treatment (week 2) IBDB35
                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 7; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                    GSM1037323

                                                                                                                                                                    Excluded

                                                                                                                                                                    After treatment (week 2) IBDB36

                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                          • After treatment (week 2) IBDB36 PBMC cell type: PBMC; subject: Patient 8; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                            • After treatment (week 2) IBDB36 PBMC cell type: PBMC; subject: Patient 8; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                          Source metadata
                                                                                                                                                                          Source name
                                                                                                                                                                          PBMC
                                                                                                                                                                          Characteristics
                                                                                                                                                                          cell type: PBMC; subject: Patient 8; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                          Description
                                                                                                                                                                          Not reported
                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                          Source
                                                                                                                                                                          GEO
                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                          sample_accession: GSM1037323
                                                                                                                                                                          sample_title: After treatment (week 2) IBDB36
                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 8; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                          GSM1037324

                                                                                                                                                                          Excluded

                                                                                                                                                                          After treatment (week 2) IBDB38

                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                • After treatment (week 2) IBDB38 PBMC cell type: PBMC; subject: Patient 9; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                  • After treatment (week 2) IBDB38 PBMC cell type: PBMC; subject: Patient 9; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                Source metadata
                                                                                                                                                                                Source name
                                                                                                                                                                                PBMC
                                                                                                                                                                                Characteristics
                                                                                                                                                                                cell type: PBMC; subject: Patient 9; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                Description
                                                                                                                                                                                Not reported
                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Source
                                                                                                                                                                                GEO
                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                sample_accession: GSM1037324
                                                                                                                                                                                sample_title: After treatment (week 2) IBDB38
                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 9; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                GSM1037325

                                                                                                                                                                                Excluded

                                                                                                                                                                                After treatment (week 2) IBDB43

                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                      • After treatment (week 2) IBDB43 PBMC cell type: PBMC; subject: Patient 10; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                        • After treatment (week 2) IBDB43 PBMC cell type: PBMC; subject: Patient 10; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                      Source metadata
                                                                                                                                                                                      Source name
                                                                                                                                                                                      PBMC
                                                                                                                                                                                      Characteristics
                                                                                                                                                                                      cell type: PBMC; subject: Patient 10; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                      Description
                                                                                                                                                                                      Not reported
                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                      Source
                                                                                                                                                                                      GEO
                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                      sample_accession: GSM1037325
                                                                                                                                                                                      sample_title: After treatment (week 2) IBDB43
                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 10; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                      GSM1037326

                                                                                                                                                                                      Excluded

                                                                                                                                                                                      After treatment (week 2) IBDB46

                                                                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                            • After treatment (week 2) IBDB46 PBMC cell type: PBMC; subject: Patient 11; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                              • After treatment (week 2) IBDB46 PBMC cell type: PBMC; subject: Patient 11; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                            Source metadata
                                                                                                                                                                                            Source name
                                                                                                                                                                                            PBMC
                                                                                                                                                                                            Characteristics
                                                                                                                                                                                            cell type: PBMC; subject: Patient 11; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                            Description
                                                                                                                                                                                            Not reported
                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                            Source
                                                                                                                                                                                            GEO
                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                            sample_accession: GSM1037326
                                                                                                                                                                                            sample_title: After treatment (week 2) IBDB46
                                                                                                                                                                                            source_name: PBMC
                                                                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 11; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                            GSM1037327

                                                                                                                                                                                            Excluded

                                                                                                                                                                                            After treatment (week 2) IBDB49

                                                                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                  • After treatment (week 2) IBDB49 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                    • After treatment (week 2) IBDB49 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                  Source name
                                                                                                                                                                                                  PBMC
                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                  cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                  Description
                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                  Source
                                                                                                                                                                                                  GEO
                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                  sample_accession: GSM1037327
                                                                                                                                                                                                  sample_title: After treatment (week 2) IBDB49
                                                                                                                                                                                                  source_name: PBMC
                                                                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                  GSM1037328

                                                                                                                                                                                                  Excluded

                                                                                                                                                                                                  After treatment (week 2) IBDB47

                                                                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                        • After treatment (week 2) IBDB47 PBMC cell type: PBMC; subject: Patient 13; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                          • After treatment (week 2) IBDB47 PBMC cell type: PBMC; subject: Patient 13; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                        Source name
                                                                                                                                                                                                        PBMC
                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                        cell type: PBMC; subject: Patient 13; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                        Description
                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                        Source
                                                                                                                                                                                                        GEO
                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                        sample_accession: GSM1037328
                                                                                                                                                                                                        sample_title: After treatment (week 2) IBDB47
                                                                                                                                                                                                        source_name: PBMC
                                                                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 13; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                        GSM1037329

                                                                                                                                                                                                        Excluded

                                                                                                                                                                                                        After treatment (week 2) IBDB45

                                                                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                              • After treatment (week 2) IBDB45 PBMC cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                • After treatment (week 2) IBDB45 PBMC cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                              Source name
                                                                                                                                                                                                              PBMC
                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                              cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                              Description
                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Source
                                                                                                                                                                                                              GEO
                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                              sample_accession: GSM1037329
                                                                                                                                                                                                              sample_title: After treatment (week 2) IBDB45
                                                                                                                                                                                                              source_name: PBMC
                                                                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 14; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                              GSM1037330

                                                                                                                                                                                                              Excluded

                                                                                                                                                                                                              After treatment (week 2) IBDB31

                                                                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                    • After treatment (week 2) IBDB31 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                      • After treatment (week 2) IBDB31 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                    PBMC
                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                    cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                    sample_accession: GSM1037330
                                                                                                                                                                                                                    sample_title: After treatment (week 2) IBDB31
                                                                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                                    GSM1037331

                                                                                                                                                                                                                    Excluded

                                                                                                                                                                                                                    After treatment (week 2) IBDB25

                                                                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                          • After treatment (week 2) IBDB25 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                            • After treatment (week 2) IBDB25 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                          PBMC
                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                          cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                          sample_accession: GSM1037331
                                                                                                                                                                                                                          sample_title: After treatment (week 2) IBDB25
                                                                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                                          GSM1037332

                                                                                                                                                                                                                          Excluded

                                                                                                                                                                                                                          After treatment (week 2) IBDB15

                                                                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                • After treatment (week 2) IBDB15 PBMC cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                  • After treatment (week 2) IBDB15 PBMC cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                PBMC
                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                sample_accession: GSM1037332
                                                                                                                                                                                                                                sample_title: After treatment (week 2) IBDB15
                                                                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 17; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                                                GSM1037333

                                                                                                                                                                                                                                Excluded

                                                                                                                                                                                                                                After treatment (week 2) IBDB11

                                                                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                      • After treatment (week 2) IBDB11 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                        • After treatment (week 2) IBDB11 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                      PBMC
                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                      cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                      sample_accession: GSM1037333
                                                                                                                                                                                                                                      sample_title: After treatment (week 2) IBDB11
                                                                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                                                      GSM1037334

                                                                                                                                                                                                                                      Excluded

                                                                                                                                                                                                                                      After treatment (week 2) IBDB05

                                                                                                                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                            • After treatment (week 2) IBDB05 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                              • After treatment (week 2) IBDB05 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                            PBMC
                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                            cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                            sample_accession: GSM1037334
                                                                                                                                                                                                                                            sample_title: After treatment (week 2) IBDB05
                                                                                                                                                                                                                                            source_name: PBMC
                                                                                                                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                                                            GSM1037335

                                                                                                                                                                                                                                            Excluded

                                                                                                                                                                                                                                            After treatment (week 2) IBDB02

                                                                                                                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                  • After treatment (week 2) IBDB02 PBMC cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                    • After treatment (week 2) IBDB02 PBMC cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                  PBMC
                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                  cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease
                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                  sample_accession: GSM1037335
                                                                                                                                                                                                                                                  sample_title: After treatment (week 2) IBDB02
                                                                                                                                                                                                                                                  source_name: PBMC
                                                                                                                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 20; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Crohn's disease

                                                                                                                                                                                                                                                  GSM1037336

                                                                                                                                                                                                                                                  Excluded

                                                                                                                                                                                                                                                  Before treatment (week 0) RAB07

                                                                                                                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                        • Before treatment (week 0) RAB07 PBMC cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                          • Before treatment (week 0) RAB07 PBMC cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                        PBMC
                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                        cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                        sample_accession: GSM1037336
                                                                                                                                                                                                                                                        sample_title: Before treatment (week 0) RAB07
                                                                                                                                                                                                                                                        source_name: PBMC
                                                                                                                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                        GSM1037337

                                                                                                                                                                                                                                                        Excluded

                                                                                                                                                                                                                                                        Before treatment (week 0) RAB101

                                                                                                                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                              • Before treatment (week 0) RAB101 PBMC cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                • Before treatment (week 0) RAB101 PBMC cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                              PBMC
                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                              cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                              sample_accession: GSM1037337
                                                                                                                                                                                                                                                              sample_title: Before treatment (week 0) RAB101
                                                                                                                                                                                                                                                              source_name: PBMC
                                                                                                                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                              GSM1037338

                                                                                                                                                                                                                                                              Excluded

                                                                                                                                                                                                                                                              Before treatment (week 0) RAB103

                                                                                                                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                    • Before treatment (week 0) RAB103 PBMC cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                      • Before treatment (week 0) RAB103 PBMC cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                    PBMC
                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                    cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                    sample_accession: GSM1037338
                                                                                                                                                                                                                                                                    sample_title: Before treatment (week 0) RAB103
                                                                                                                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                    GSM1037339

                                                                                                                                                                                                                                                                    Excluded

                                                                                                                                                                                                                                                                    Before treatment (week 0) RAB104

                                                                                                                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                          • Before treatment (week 0) RAB104 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                            • Before treatment (week 0) RAB104 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                          PBMC
                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                          cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                          sample_accession: GSM1037339
                                                                                                                                                                                                                                                                          sample_title: Before treatment (week 0) RAB104
                                                                                                                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                          GSM1037340

                                                                                                                                                                                                                                                                          Excluded

                                                                                                                                                                                                                                                                          Before treatment (week 0) RAB31

                                                                                                                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                • Before treatment (week 0) RAB31 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                  • Before treatment (week 0) RAB31 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                PBMC
                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                sample_accession: GSM1037340
                                                                                                                                                                                                                                                                                sample_title: Before treatment (week 0) RAB31
                                                                                                                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                GSM1037341

                                                                                                                                                                                                                                                                                Excluded

                                                                                                                                                                                                                                                                                Before treatment (week 0) RAB41

                                                                                                                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                      • Before treatment (week 0) RAB41 PBMC cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                        • Before treatment (week 0) RAB41 PBMC cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                      PBMC
                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                      cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                      sample_accession: GSM1037341
                                                                                                                                                                                                                                                                                      sample_title: Before treatment (week 0) RAB41
                                                                                                                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                      GSM1037342

                                                                                                                                                                                                                                                                                      Excluded

                                                                                                                                                                                                                                                                                      Before treatment (week 0) RAB63

                                                                                                                                                                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                            • Before treatment (week 0) RAB63 PBMC cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                              • Before treatment (week 0) RAB63 PBMC cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                            PBMC
                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                            cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                            sample_accession: GSM1037342
                                                                                                                                                                                                                                                                                            sample_title: Before treatment (week 0) RAB63
                                                                                                                                                                                                                                                                                            source_name: PBMC
                                                                                                                                                                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                            GSM1037343

                                                                                                                                                                                                                                                                                            Excluded

                                                                                                                                                                                                                                                                                            Before treatment (week 0) RAB72

                                                                                                                                                                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                  • Before treatment (week 0) RAB72 PBMC cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                    • Before treatment (week 0) RAB72 PBMC cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                  PBMC
                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                  cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                  sample_accession: GSM1037343
                                                                                                                                                                                                                                                                                                  sample_title: Before treatment (week 0) RAB72
                                                                                                                                                                                                                                                                                                  source_name: PBMC
                                                                                                                                                                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                  GSM1037344

                                                                                                                                                                                                                                                                                                  Excluded

                                                                                                                                                                                                                                                                                                  Before treatment (week 0) RAB83

                                                                                                                                                                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                        • Before treatment (week 0) RAB83 PBMC cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                          • Before treatment (week 0) RAB83 PBMC cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arth...
                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                        PBMC
                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                        cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                        sample_accession: GSM1037344
                                                                                                                                                                                                                                                                                                        sample_title: Before treatment (week 0) RAB83
                                                                                                                                                                                                                                                                                                        source_name: PBMC
                                                                                                                                                                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                        GSM1037345

                                                                                                                                                                                                                                                                                                        Excluded

                                                                                                                                                                                                                                                                                                        Before treatment (week 0) RAB90

                                                                                                                                                                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                              • Before treatment (week 0) RAB90 PBMC cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                • Before treatment (week 0) RAB90 PBMC cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                              PBMC
                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                              cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                              sample_accession: GSM1037345
                                                                                                                                                                                                                                                                                                              sample_title: Before treatment (week 0) RAB90
                                                                                                                                                                                                                                                                                                              source_name: PBMC
                                                                                                                                                                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                              GSM1037346

                                                                                                                                                                                                                                                                                                              Excluded

                                                                                                                                                                                                                                                                                                              Before treatment (week 0) RAB93

                                                                                                                                                                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                    • Before treatment (week 0) RAB93 PBMC cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                      • Before treatment (week 0) RAB93 PBMC cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                    PBMC
                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                    cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                    sample_accession: GSM1037346
                                                                                                                                                                                                                                                                                                                    sample_title: Before treatment (week 0) RAB93
                                                                                                                                                                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                    GSM1037347

                                                                                                                                                                                                                                                                                                                    Excluded

                                                                                                                                                                                                                                                                                                                    Before treatment (week 0) RAB97

                                                                                                                                                                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                          • Before treatment (week 0) RAB97 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                            • Before treatment (week 0) RAB97 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                          PBMC
                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                          cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                          sample_accession: GSM1037347
                                                                                                                                                                                                                                                                                                                          sample_title: Before treatment (week 0) RAB97
                                                                                                                                                                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                          GSM1037348

                                                                                                                                                                                                                                                                                                                          Excluded

                                                                                                                                                                                                                                                                                                                          Before treatment (week 0) RAB98

                                                                                                                                                                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                • Before treatment (week 0) RAB98 PBMC cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                  • Before treatment (week 0) RAB98 PBMC cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid art...
                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                PBMC
                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                sample_accession: GSM1037348
                                                                                                                                                                                                                                                                                                                                sample_title: Before treatment (week 0) RAB98
                                                                                                                                                                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                GSM1037349

                                                                                                                                                                                                                                                                                                                                Excluded

                                                                                                                                                                                                                                                                                                                                Before treatment (week 0) RAB28

                                                                                                                                                                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                      • Before treatment (week 0) RAB28 PBMC cell type: PBMC; subject: Patient 14; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                        • Before treatment (week 0) RAB28 PBMC cell type: PBMC; subject: Patient 14; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                      PBMC
                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                      cell type: PBMC; subject: Patient 14; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM1037349
                                                                                                                                                                                                                                                                                                                                      sample_title: Before treatment (week 0) RAB28
                                                                                                                                                                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 14; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                      GSM1037350

                                                                                                                                                                                                                                                                                                                                      Excluded

                                                                                                                                                                                                                                                                                                                                      Before treatment (week 0) RAB35

                                                                                                                                                                                                                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                            • Before treatment (week 0) RAB35 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                              • Before treatment (week 0) RAB35 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                            PBMC
                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                            cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM1037350
                                                                                                                                                                                                                                                                                                                                            sample_title: Before treatment (week 0) RAB35
                                                                                                                                                                                                                                                                                                                                            source_name: PBMC
                                                                                                                                                                                                                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 15; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                            GSM1037351

                                                                                                                                                                                                                                                                                                                                            Excluded

                                                                                                                                                                                                                                                                                                                                            Before treatment (week 0) RAB42

                                                                                                                                                                                                                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                  • Before treatment (week 0) RAB42 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                    • Before treatment (week 0) RAB42 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                  PBMC
                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                  cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM1037351
                                                                                                                                                                                                                                                                                                                                                  sample_title: Before treatment (week 0) RAB42
                                                                                                                                                                                                                                                                                                                                                  source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 16; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                  GSM1037352

                                                                                                                                                                                                                                                                                                                                                  Excluded

                                                                                                                                                                                                                                                                                                                                                  Before treatment (week 0) RAB53

                                                                                                                                                                                                                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                        • Before treatment (week 0) RAB53 PBMC cell type: PBMC; subject: Patient 17; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                          • Before treatment (week 0) RAB53 PBMC cell type: PBMC; subject: Patient 17; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                        PBMC
                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                        cell type: PBMC; subject: Patient 17; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM1037352
                                                                                                                                                                                                                                                                                                                                                        sample_title: Before treatment (week 0) RAB53
                                                                                                                                                                                                                                                                                                                                                        source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 17; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                        GSM1037353

                                                                                                                                                                                                                                                                                                                                                        Excluded

                                                                                                                                                                                                                                                                                                                                                        Before treatment (week 0) RAB56

                                                                                                                                                                                                                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                              • Before treatment (week 0) RAB56 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                • Before treatment (week 0) RAB56 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                              PBMC
                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                              cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM1037353
                                                                                                                                                                                                                                                                                                                                                              sample_title: Before treatment (week 0) RAB56
                                                                                                                                                                                                                                                                                                                                                              source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 18; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                              GSM1037354

                                                                                                                                                                                                                                                                                                                                                              Excluded

                                                                                                                                                                                                                                                                                                                                                              Before treatment (week 0) RAB60

                                                                                                                                                                                                                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                    • Before treatment (week 0) RAB60 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                      • Before treatment (week 0) RAB60 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                    PBMC
                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                    cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM1037354
                                                                                                                                                                                                                                                                                                                                                                    sample_title: Before treatment (week 0) RAB60
                                                                                                                                                                                                                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 19; response: R - responder; treatment: Before treatment; time: week 0; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                    GSM1037355

                                                                                                                                                                                                                                                                                                                                                                    Excluded

                                                                                                                                                                                                                                                                                                                                                                    After treatment (week 2) RAB17

                                                                                                                                                                                                                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                          • After treatment (week 2) RAB17 PBMC cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                            • After treatment (week 2) RAB17 PBMC cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                          PBMC
                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                          cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM1037355
                                                                                                                                                                                                                                                                                                                                                                          sample_title: After treatment (week 2) RAB17
                                                                                                                                                                                                                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 1; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                          GSM1037356

                                                                                                                                                                                                                                                                                                                                                                          Excluded

                                                                                                                                                                                                                                                                                                                                                                          After treatment (week 2) RAB105

                                                                                                                                                                                                                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                • After treatment (week 2) RAB105 PBMC cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                  • After treatment (week 2) RAB105 PBMC cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                PBMC
                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM1037356
                                                                                                                                                                                                                                                                                                                                                                                sample_title: After treatment (week 2) RAB105
                                                                                                                                                                                                                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 2; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                GSM1037357

                                                                                                                                                                                                                                                                                                                                                                                Excluded

                                                                                                                                                                                                                                                                                                                                                                                After treatment (week 2) RAB106

                                                                                                                                                                                                                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                      • After treatment (week 2) RAB106 PBMC cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                        • After treatment (week 2) RAB106 PBMC cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                      PBMC
                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                      cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM1037357
                                                                                                                                                                                                                                                                                                                                                                                      sample_title: After treatment (week 2) RAB106
                                                                                                                                                                                                                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 3; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                      GSM1037358

                                                                                                                                                                                                                                                                                                                                                                                      Excluded

                                                                                                                                                                                                                                                                                                                                                                                      After treatment (week 2) RAB107

                                                                                                                                                                                                                                                                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                            • After treatment (week 2) RAB107 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                              • After treatment (week 2) RAB107 PBMC cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                            PBMC
                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                            cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM1037358
                                                                                                                                                                                                                                                                                                                                                                                            sample_title: After treatment (week 2) RAB107
                                                                                                                                                                                                                                                                                                                                                                                            source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 4; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                            GSM1037359

                                                                                                                                                                                                                                                                                                                                                                                            Excluded

                                                                                                                                                                                                                                                                                                                                                                                            After treatment (week 2) RAB43

                                                                                                                                                                                                                                                                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                  • After treatment (week 2) RAB43 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                    • After treatment (week 2) RAB43 PBMC cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                  PBMC
                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                  cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM1037359
                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: After treatment (week 2) RAB43
                                                                                                                                                                                                                                                                                                                                                                                                  source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 5; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                  GSM1037360

                                                                                                                                                                                                                                                                                                                                                                                                  Excluded

                                                                                                                                                                                                                                                                                                                                                                                                  After treatment (week 2) RAB50

                                                                                                                                                                                                                                                                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                        • After treatment (week 2) RAB50 PBMC cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                          • After treatment (week 2) RAB50 PBMC cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                        PBMC
                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                        cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM1037360
                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: After treatment (week 2) RAB50
                                                                                                                                                                                                                                                                                                                                                                                                        source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 6; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                        GSM1037361

                                                                                                                                                                                                                                                                                                                                                                                                        Excluded

                                                                                                                                                                                                                                                                                                                                                                                                        After treatment (week 2) RAB66

                                                                                                                                                                                                                                                                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                              • After treatment (week 2) RAB66 PBMC cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                • After treatment (week 2) RAB66 PBMC cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                              PBMC
                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                              cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM1037361
                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: After treatment (week 2) RAB66
                                                                                                                                                                                                                                                                                                                                                                                                              source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 7; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                              GSM1037362

                                                                                                                                                                                                                                                                                                                                                                                                              Excluded

                                                                                                                                                                                                                                                                                                                                                                                                              After treatment (week 2) RAB75

                                                                                                                                                                                                                                                                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                    • After treatment (week 2) RAB75 PBMC cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                      • After treatment (week 2) RAB75 PBMC cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                    PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                    cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM1037362
                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: After treatment (week 2) RAB75
                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 8; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                    GSM1037363

                                                                                                                                                                                                                                                                                                                                                                                                                    Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                    After treatment (week 2) RAB87

                                                                                                                                                                                                                                                                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                          • After treatment (week 2) RAB87 PBMC cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                            • After treatment (week 2) RAB87 PBMC cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                          PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                          cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM1037363
                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: After treatment (week 2) RAB87
                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 9; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                          GSM1037364

                                                                                                                                                                                                                                                                                                                                                                                                                          Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                          After treatment (week 2) RAB94

                                                                                                                                                                                                                                                                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                • After treatment (week 2) RAB94 PBMC cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                  • After treatment (week 2) RAB94 PBMC cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM1037364
                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: After treatment (week 2) RAB94
                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 10; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                GSM1037365

                                                                                                                                                                                                                                                                                                                                                                                                                                Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                After treatment (week 2) RAB96

                                                                                                                                                                                                                                                                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                      • After treatment (week 2) RAB96 PBMC cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                        • After treatment (week 2) RAB96 PBMC cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                      PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                      cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM1037365
                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: After treatment (week 2) RAB96
                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 11; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                      GSM1037366

                                                                                                                                                                                                                                                                                                                                                                                                                                      Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                      After treatment (week 2) RAB100

                                                                                                                                                                                                                                                                                                                                                                                                                                      Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                            • After treatment (week 2) RAB100 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                              • After treatment (week 2) RAB100 PBMC cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                            PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                            cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_accession: GSM1037366
                                                                                                                                                                                                                                                                                                                                                                                                                                            sample_title: After treatment (week 2) RAB100
                                                                                                                                                                                                                                                                                                                                                                                                                                            source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                            characteristics: cell type: PBMC; subject: Patient 12; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                            GSM1037367

                                                                                                                                                                                                                                                                                                                                                                                                                                            Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                            After treatment (week 2) RAB102

                                                                                                                                                                                                                                                                                                                                                                                                                                            Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • After treatment (week 2) RAB102 PBMC cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • After treatment (week 2) RAB102 PBMC cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                  PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                  cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM1037367
                                                                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: After treatment (week 2) RAB102
                                                                                                                                                                                                                                                                                                                                                                                                                                                  source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: cell type: PBMC; subject: Patient 13; response: NR - non-responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                                  GSM1037368

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                                  After treatment (week 2) RAB38

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • After treatment (week 2) RAB38 PBMC cell type: PBMC; subject: Patient 14; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • After treatment (week 2) RAB38 PBMC cell type: PBMC; subject: Patient 14; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                        PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                        cell type: PBMC; subject: Patient 14; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM1037368
                                                                                                                                                                                                                                                                                                                                                                                                                                                        sample_title: After treatment (week 2) RAB38
                                                                                                                                                                                                                                                                                                                                                                                                                                                        source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                        characteristics: cell type: PBMC; subject: Patient 14; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                                        GSM1037369

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                                        After treatment (week 2) RAB44

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • After treatment (week 2) RAB44 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • After treatment (week 2) RAB44 PBMC cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                              PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                              cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM1037369
                                                                                                                                                                                                                                                                                                                                                                                                                                                              sample_title: After treatment (week 2) RAB44
                                                                                                                                                                                                                                                                                                                                                                                                                                                              source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                              characteristics: cell type: PBMC; subject: Patient 15; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                                              GSM1037370

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                                              After treatment (week 2) RAB52

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • After treatment (week 2) RAB52 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • After treatment (week 2) RAB52 PBMC cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM1037370
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    sample_title: After treatment (week 2) RAB52
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    characteristics: cell type: PBMC; subject: Patient 16; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSM1037371

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    After treatment (week 2) RAB59

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • After treatment (week 2) RAB59 PBMC cell type: PBMC; subject: Patient 17; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • After treatment (week 2) RAB59 PBMC cell type: PBMC; subject: Patient 17; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cell type: PBMC; subject: Patient 17; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM1037371
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sample_title: After treatment (week 2) RAB59
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          characteristics: cell type: PBMC; subject: Patient 17; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GSM1037372

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          After treatment (week 2) RAB62

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • After treatment (week 2) RAB62 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • After treatment (week 2) RAB62 PBMC cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM1037372
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                sample_title: After treatment (week 2) RAB62
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                characteristics: cell type: PBMC; subject: Patient 18; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GSM1037373

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Excluded

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                After treatment (week 2) RAB68

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Excluded: at least one selected requirement is not met. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Does not meet requirement. specimen category excludes: Biofluid — Does not meet requirement. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • After treatment (week 2) RAB68 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Does not meet requirement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • The reported value differs from the selected requirement.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • After treatment (week 2) RAB68 PBMC cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM1037373
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      sample_title: After treatment (week 2) RAB68
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      source_name: PBMC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      characteristics: cell type: PBMC; subject: Patient 19; response: R - responder; treatment: infliximab; time: week 2; disease state: Rheumatoid arthritis