GSE68306

miR-193a-3p is a key tumor-suppressor in ulcerative colitis-associated colon cancer and promotes carcinogenesis through regulation of IL17RD.

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

20 case / 16 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

Patients with ulcerative colitis (UC) are at increased risk for colorectal cancer although mechanisms remain poorly understood. We sought to evaluate the role of miRNAs in neoplasia development in this high-risk population

Overall design

RNA was extracted from formalin fixed paraffin embedded tissue from  controls (n=12), UC without neoplasia (UC, n=9), UC-associated neoplastic tissue (UCN, n=10; HGD-4, CRC-6) and adjacent tissue (n=9). miRNA array analysis was performed using the Nanostring nCounter System v1

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
45 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

1 linked publication 1 DOI

Primary publication

  1. miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD. Clinical cancer research : an official journal of the American Association for Cancer Research, 2017
Available

Metadata Quality Components

Analysis Readiness

Review before analysis
85% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

3/15 pts

Unassigned or review-needed samples remain before analysis.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • 9 samples are still unassigned.
  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Resolve unassigned or review-needed samples in the grouping table.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Needs review

0 review-needed samples and 9 unassigned samples remain.

Resolve ambiguous and unassigned samples before finalizing the contrast.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

One or more samples are unassigned and need manual grouping decisions.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Colorectal cancer, ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Ulcerative colitis 20 samples
  • Likely control group Healthy control 16 samples

Intent Interpretation

  • Downgrade or exclusion reason Downgraded assay: microarray cohorts are separated from the RNA-seq intent. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Biopsy. Comparison suitability: 0%.
  • Interpreted disease metadata: Colorectal cancer, Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 1 publication; 1 DOI available: PMID 28600480.
  • Publication context: miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. PMID 28600480. DOI 10.1158/1078-0432.CCR-17-0171.

Cautions

  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

221 fields

Sample Group Preview

45 rows shown
Show Hide
Study totals: Case 20 | Control 16 | Unassigned 9 | Excluded 0 | Ambiguous 0 45 rows shown
Group Role Accession Title Source / characteristics Reason
Ulcerative colitis Case GSM1667305 NS34 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667308 NS7 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667309 NS9 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667312 NS16 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667313 NS17 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667314 NS18 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667316 NS20 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667317 NS21 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667318 NS22 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667325 NS29 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667326 NS30 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667327 NS31 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667328 NS32 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667329 NS33 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667330 NS35 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667337 NS42 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667338 NS43 Colon Diagnosis: UC patients without neoplasia; Group: UC; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667339 NS44 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Ulcerative colitis Case GSM1667340 NS45 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Right colon Case marker detected.
Ulcerative colitis Case GSM1667341 NS46 Colon Diagnosis: Ulcerative colitis associated neoplastic tissues; Group: UCN; Tissue: Colon; Sampling: Biopsy; Location: Left colon Case marker detected.
Healthy control Control GSM1667299 NS1 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667303 NS2 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Right colon Sample-local control marker detected.
Healthy control Control GSM1667304 NS3 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667306 NS4 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667307 NS6 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Right colon Sample-local control marker detected.
Healthy control Control GSM1667310 NS13 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667311 NS14 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667321 NS25 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667322 NS26 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Right colon Sample-local control marker detected.
Healthy control Control GSM1667323 NS27 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667324 NS28 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Right colon Sample-local control marker detected.
Healthy control Control GSM1667332 NS37 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667333 NS38 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667334 NS39 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Healthy control Control GSM1667335 NS40 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Right colon Sample-local control marker detected.
Healthy control Control GSM1667336 NS41 Colon Diagnosis: Normal; Group: Normal; Tissue: Colon; Sampling: Biopsy; Location: Left colon Sample-local control marker detected.
Unassigned Unassigned GSM1667300 NS10 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Right colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667301 NS11 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Left colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667302 NS12 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Right colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667315 NS19 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Left colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667319 NS23 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Right colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667320 NS24 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Right colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667331 NS36 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Left colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667342 NS47 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Left colon No explicit case or control marker detected.
Unassigned Unassigned GSM1667343 NS48 Colon Diagnosis: Non-dysplastic UC mucosa adjacent to a neoplastic lesion; Group: nUCaN; Tissue: Colon; Sampling: Biopsy; Location: Left colon No explicit case or control marker detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.