GSE72221

Characterization of LncRNA BC012900 among long non-coding RNAs differentially expressed in ulcerative colitis

Whole-study status Not suitable

Dataset does not meet the current suitability threshold.

Whole-study downloads — these do not apply your sample requirements.

Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

View matching samples

34 case / 22 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

Summary

In this report, we provide a comprehensive assessment of the expression of ~17000 lncRNAs on 60 colonic samplesin colon tissues from patients with IBD, irritable bowel syndrome, infectious colitis and healthy controls. We also explored the possibility of using cRNAs as biomarkers distinguish active UC from normal. To investigate the mechanism offunctional role these IBD-associated lncRNAs in the development of IBD, we then focused on a ncRNA highlyexpressed in the UC-associated lncRNAactive UC, BC012900. We , to characterized its cellular localization, expression regulation and biological function. We . We found that BC012900 and its adjacent gene, dual specificity phosphatase 4 (DUSP4) are functionally distinct, with BC012900 modulating. Overexpression of BC012900 resulted in usceptibility to apoptosis. Our study provides the first evidence that lncRNAs may play potential roles in development and persistence of active UC.

Overall design

LncRNAs microarray and quantitative RT-PCR were performed on 60 sigmoid biopsies from patients with active ulcerative colitis (UC) and relevant controls.

Source Evidence

4 sources
Source Contribution Status
GEO

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Sample records
57 GSM samples
Primary source
recount3

Planned trusted source for processed count availability.

No match found
Expression Atlas

Planned source for curated expression experiment links.

No match found
PubMed

Primary GEO citations and related PubMed articles that mention this dataset.

1 linked publication 1 DOI

Primary publication

  1. Ulcerative Colitis-Associated Long Noncoding RNA, BC012900, Regulates Intestinal Epithelial Cell Apoptosis. Inflammatory bowel diseases, 2016
Available

Metadata Quality Components

Analysis Readiness

Review before analysis
90% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

8/15 pts

A small number of samples remain unassigned.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • 1 samples are still unassigned.
  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Resolve unassigned or review-needed samples in the grouping table.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Needs review

0 review-needed samples and 1 unassigned samples remain.

Resolve ambiguous and unassigned samples before finalizing the contrast.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source traceability preserved

Ready

The dataset and sample accessions can be traced back to GEO.

Keep GEO accessions with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

Analysis readiness has blockers that must be resolved before DE.

One or more samples are unassigned and need manual grouping decisions.

Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Tumor vs normal
Not suitable Dataset does not meet the current suitability threshold.

Applied Review Decisions

No active review decisions affect this ranking.

Derived Classifications

  • Assay differs from search intent Microarray Search intent expects bulk RNA-seq. Assay came from Normalization rules.
  • Disease context Crohn's disease, inflammatory bowel disease, ulcerative colitis Disease context came from Normalization rules.
  • Likely case group Ulcerative colitis 34 samples
  • Likely control group Mixed controls 22 samples

Intent Interpretation

  • Downgrade or exclusion reason Downgraded assay: microarray cohorts are separated from the RNA-seq intent. Derived from current-intent ranking reasons.

Ranking Facts

Supporting evidence

  • Comparison: Disease/model vs control. Specimen: Biopsy. Comparison suitability: 0%.
  • Interpreted disease metadata: Crohn's disease, Infectious disease or host response, Inflammatory bowel disease, Ulcerative colitis.
  • Processed data is available for downstream review.
  • External evidence: PubMed links 1 publication; 1 DOI available: PMID 26937624.
  • Publication context: Ulcerative Colitis-Associated Long Noncoding RNA, BC012900, Regulates Intestinal Epithelial Cell Apoptosis.. Inflammatory bowel diseases, 2016. PMID 26937624. DOI 10.1097/MIB.0000000000000691.

Cautions

  • Downgraded assay: microarray cohorts are separated from the RNA-seq intent.
  • Disease/control design without a tumor/normal comparison is outside tumor/normal triage.
  • Microarray expression context downgraded below primary bulk RNA-seq for the default tissue ranking.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because microarray cohorts should be compared separately from RNA-seq cohorts.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Dataset Warnings

Normalized Fields

175 fields

Sample Group Preview

57 rows shown
Show Hide
Study totals: Case 34 | Control 22 | Unassigned 1 | Excluded 0 | Ambiguous 0 57 rows shown
Group Role Accession Title Source / characteristics Reason
Ulcerative colitis Case GSM1858009 UC100ina_10698_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858010 UC105ina_10661_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858011 UC109ina_10754_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858012 UC118ina_10752_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858013 UC121ina_10802_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858014 UC127ina_10750_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858015 UC130ina_10800_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858016 UC159ina_10756_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858017 UC165ina_0649_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858018 UC167act_10756_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858019 UC183ina_10757_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858020 UC70ina_110708_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858021 UC87ina_110707_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858022 UC90ina_110727_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858023 UC93ina_10700_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Inactive; Group: iUC Case marker detected.
Ulcerative colitis Case GSM1858024 UC110act_10701_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858025 UC139act_10697_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858026 UC143act_10755_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858027 UC144act_10758_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858028 UC148act_10752_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858029 UC153act_10751_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858030 UC161act_10803_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858031 UC168act_10801_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858032 UC169act_10753_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858033 UC178act_10769_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858034 UC63act_0640_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858035 UC71act_110711_2 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858036 UC73act2_10772_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Ulcerative colitis Case GSM1858037 UC74act_110708_1 Biopsy Diagnosis: Ulcerative colitis; Activity: Active; Group: aUC Case marker detected.
Crohn's disease Case GSM1858038 CD111act_10698_2 Biopsy Diagnosis: Crohn’s disease; Activity: Active; Group: aCD Case marker detected.
Crohn's disease Case GSM1858039 CD131act_10750_2 Biopsy Diagnosis: Crohn’s disease; Activity: Active; Group: aCD Case marker detected.
Crohn's disease Case GSM1858040 CD150act_10802_2 Biopsy Diagnosis: Crohn’s disease; Activity: Active; Group: aCD Case marker detected.
Crohn's disease Case GSM1858041 CD33act_110707_1 Biopsy Diagnosis: Crohn’s disease; Activity: Active; Group: aCD Case marker detected.
Crohn's disease Case GSM1858042 CD84act2_10772_2 Biopsy Diagnosis: Crohn’s disease; Activity: Active; Group: aCD Case marker detected.
Normal tissue Control GSM1857992 INF156_10661_2 Biopsy Diagnosis: Infectious colitis; Activity: Normal; Group: INF Control marker detected.
Normal tissue Control GSM1857993 INF157_10754_2 Biopsy Diagnosis: Infectious colitis; Activity: Normal; Group: INF Control marker detected.
Normal tissue Control GSM1857994 INF246_10800_2 Biopsy Diagnosis: Infectious colitis; Activity: Normal; Group: INF Control marker detected.
Healthy control Control GSM1857995 N104_110710_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1857996 N122_0649_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1857997 N188_10701_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1857998 N190_10699_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1857999 N195_10697_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858000 N199_10755_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858001 N209_10753_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858002 N210_10751_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858003 N212_10801_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858004 N226_10803_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858005 N234_10758_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858006 N239_10757_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858007 N66_0640_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Healthy control Control GSM1858008 N94_110711_1 Biopsy Diagnosis: Normal; Activity: Normal; Group: CTR Sample-local control marker detected.
Normal tissue Control GSM1858043 IBS108_10771_2 Biopsy Diagnosis: Irritable bowel syndrome; Activity: Normal; Group: IBS Control marker detected.
Normal tissue Control GSM1858044 IBS184e_10769_2 Biopsy Diagnosis: Irritable bowel syndrome; Activity: Normal; Group: IBS Control marker detected.
Normal tissue Control GSM1858045 IBS189_10770H_2 Biopsy Diagnosis: Irritable bowel syndrome; Activity: Normal; Group: IBS Control marker detected.
Normal tissue Control GSM1858046 IBS96_110727_2 Biopsy Diagnosis: Irritable bowel syndrome; Activity: Normal; Group: IBS Control marker detected.
Normal tissue Control GSM1858047 IBS99_10771_1 Biopsy Diagnosis: Irritable bowel syndrome; Activity: Normal; Group: IBS Control marker detected.
Unassigned Unassigned GSM1858048 INF255_10749_1 Biopsy Diagnosis: Infectious colitis; Activity: Active; Group: INF No explicit case or control marker detected.

Use as Discovery Cohort

External Validation Finder

Carry Siftome's disease, organism, specimen, assay, data type, and accession into a validation project. Uncertain fields remain Unknown.