Matching samples

GSE73634 · Treatment of advanced liver fibrosis in HIV- and HCV-infected adults with simtuzumab, a monoclonal antibody against lysyl oxidase-like 2: Results of a 6-month open-label safety trial

Download matching samples CSV
Selected cohort requirements

Samples meeting selected requirements: 0 cases / 0 controls

48 case / 0 control samples elsewhere in the study have incomplete or conflicting evidence; they are not included above

Patient pairs verified in indexed sample metadata: 0

A case/control comparison meeting these requirements is not confirmed.

Counts describe samples, not independent patients. Pair verification uses explicit subject identifiers in indexed sample metadata. Zero verified pairs does not establish that the study is unpaired; reported matched-normal design alone is insufficient.

The CSV contains only the confirmed cases and controls below. Excluded and uncertain samples are shown for review and are not exported.

These are sample eligibility decisions from the current indexed metadata. Study-level search filters and minimum sample counts do not establish expression quality or analysis readiness.

Included samples (0)

No samples meet the selected requirements. The CSV contains its column headers only.

Uncertain samples (48)

These samples need more evidence before they can be counted. This includes samples without a confirmed case/control role.

GSM1899804

Uncertain

Paired blood biopsy PRE treatment pair and rep 1

Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

Requirements and decision evidence
  • organism: Homo sapiens — Insufficient evidence
    • The required value is not reported.
    • assay type: bulk RNA-seq — Insufficient evidence
      • The required value is not reported.
      • specimen category: Tissue or biopsy — Insufficient evidence
        • The required value is not reported.
        • Paired blood biopsy PRE treatment pair and rep 1 paired blood biopsy PRE treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
        • Paired blood biopsy PRE treatment pair and rep 1 paired blood biopsy PRE treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
        • Supported by the indexed evidence.
        • specimen category excludes: Biofluid — Insufficient evidence
          • The required value is not reported.
          • Paired blood biopsy PRE treatment pair and rep 1 paired blood biopsy PRE treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
          • Paired blood biopsy PRE treatment pair and rep 1 paired blood biopsy PRE treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
        Source metadata
        Source name
        paired blood biopsy PRE treatment pair and rep 1
        Characteristics
        age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 1
        Description
        Not reported
        Indexed organism evidence
        INFERRED · PARENT_INHERITED: Not reported
        Indexed assay evidence
        INFERRED · PARENT_INHERITED: Not reported
        Source
        GEO
        Original indexed metadata
        sample_accession: GSM1899804
        sample_title: Paired blood biopsy PRE treatment pair and rep 1
        source_name: paired blood biopsy PRE treatment pair and rep 1
        characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 1

        GSM1899805

        Uncertain

        Paired blood biopsy PRE treatment pair and rep 2

        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

        Requirements and decision evidence
        • organism: Homo sapiens — Insufficient evidence
          • The required value is not reported.
          • assay type: bulk RNA-seq — Insufficient evidence
            • The required value is not reported.
            • specimen category: Tissue or biopsy — Insufficient evidence
              • The required value is not reported.
              • Paired blood biopsy PRE treatment pair and rep 2 paired blood biopsy PRE treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
              • Paired blood biopsy PRE treatment pair and rep 2 paired blood biopsy PRE treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
              • Supported by the indexed evidence.
              • specimen category excludes: Biofluid — Insufficient evidence
                • The required value is not reported.
                • Paired blood biopsy PRE treatment pair and rep 2 paired blood biopsy PRE treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                • Paired blood biopsy PRE treatment pair and rep 2 paired blood biopsy PRE treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
              Source metadata
              Source name
              paired blood biopsy PRE treatment pair and rep 2
              Characteristics
              age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 2
              Description
              Not reported
              Indexed organism evidence
              INFERRED · PARENT_INHERITED: Not reported
              Indexed assay evidence
              INFERRED · PARENT_INHERITED: Not reported
              Source
              GEO
              Original indexed metadata
              sample_accession: GSM1899805
              sample_title: Paired blood biopsy PRE treatment pair and rep 2
              source_name: paired blood biopsy PRE treatment pair and rep 2
              characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 2

              GSM1899806

              Uncertain

              Paired blood biopsy PRE treatment pair and rep 3

              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

              Requirements and decision evidence
              • organism: Homo sapiens — Insufficient evidence
                • The required value is not reported.
                • assay type: bulk RNA-seq — Insufficient evidence
                  • The required value is not reported.
                  • specimen category: Tissue or biopsy — Insufficient evidence
                    • The required value is not reported.
                    • Paired blood biopsy PRE treatment pair and rep 3 paired blood biopsy PRE treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                    • Paired blood biopsy PRE treatment pair and rep 3 paired blood biopsy PRE treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                    • Supported by the indexed evidence.
                    • specimen category excludes: Biofluid — Insufficient evidence
                      • The required value is not reported.
                      • Paired blood biopsy PRE treatment pair and rep 3 paired blood biopsy PRE treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                      • Paired blood biopsy PRE treatment pair and rep 3 paired blood biopsy PRE treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                    Source metadata
                    Source name
                    paired blood biopsy PRE treatment pair and rep 3
                    Characteristics
                    age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 3
                    Description
                    Not reported
                    Indexed organism evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Indexed assay evidence
                    INFERRED · PARENT_INHERITED: Not reported
                    Source
                    GEO
                    Original indexed metadata
                    sample_accession: GSM1899806
                    sample_title: Paired blood biopsy PRE treatment pair and rep 3
                    source_name: paired blood biopsy PRE treatment pair and rep 3
                    characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 3

                    GSM1899807

                    Uncertain

                    Paired blood biopsy PRE treatment pair and rep 4

                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                    Requirements and decision evidence
                    • organism: Homo sapiens — Insufficient evidence
                      • The required value is not reported.
                      • assay type: bulk RNA-seq — Insufficient evidence
                        • The required value is not reported.
                        • specimen category: Tissue or biopsy — Insufficient evidence
                          • The required value is not reported.
                          • Paired blood biopsy PRE treatment pair and rep 4 paired blood biopsy PRE treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                          • Paired blood biopsy PRE treatment pair and rep 4 paired blood biopsy PRE treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                          • Supported by the indexed evidence.
                          • specimen category excludes: Biofluid — Insufficient evidence
                            • The required value is not reported.
                            • Paired blood biopsy PRE treatment pair and rep 4 paired blood biopsy PRE treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                            • Paired blood biopsy PRE treatment pair and rep 4 paired blood biopsy PRE treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                          Source metadata
                          Source name
                          paired blood biopsy PRE treatment pair and rep 4
                          Characteristics
                          age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 4
                          Description
                          Not reported
                          Indexed organism evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Indexed assay evidence
                          INFERRED · PARENT_INHERITED: Not reported
                          Source
                          GEO
                          Original indexed metadata
                          sample_accession: GSM1899807
                          sample_title: Paired blood biopsy PRE treatment pair and rep 4
                          source_name: paired blood biopsy PRE treatment pair and rep 4
                          characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 4

                          GSM1899808

                          Uncertain

                          Paired blood biopsy PRE treatment pair and rep 5

                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                          Requirements and decision evidence
                          • organism: Homo sapiens — Insufficient evidence
                            • The required value is not reported.
                            • assay type: bulk RNA-seq — Insufficient evidence
                              • The required value is not reported.
                              • specimen category: Tissue or biopsy — Insufficient evidence
                                • The required value is not reported.
                                • Paired blood biopsy PRE treatment pair and rep 5 paired blood biopsy PRE treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                • Paired blood biopsy PRE treatment pair and rep 5 paired blood biopsy PRE treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                • Supported by the indexed evidence.
                                • specimen category excludes: Biofluid — Insufficient evidence
                                  • The required value is not reported.
                                  • Paired blood biopsy PRE treatment pair and rep 5 paired blood biopsy PRE treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                  • Paired blood biopsy PRE treatment pair and rep 5 paired blood biopsy PRE treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                Source metadata
                                Source name
                                paired blood biopsy PRE treatment pair and rep 5
                                Characteristics
                                age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 5
                                Description
                                Not reported
                                Indexed organism evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Indexed assay evidence
                                INFERRED · PARENT_INHERITED: Not reported
                                Source
                                GEO
                                Original indexed metadata
                                sample_accession: GSM1899808
                                sample_title: Paired blood biopsy PRE treatment pair and rep 5
                                source_name: paired blood biopsy PRE treatment pair and rep 5
                                characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 5

                                GSM1899809

                                Uncertain

                                Paired blood biopsy PRE treatment pair and rep 6

                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                Requirements and decision evidence
                                • organism: Homo sapiens — Insufficient evidence
                                  • The required value is not reported.
                                  • assay type: bulk RNA-seq — Insufficient evidence
                                    • The required value is not reported.
                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                      • The required value is not reported.
                                      • Paired blood biopsy PRE treatment pair and rep 6 paired blood biopsy PRE treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                      • Paired blood biopsy PRE treatment pair and rep 6 paired blood biopsy PRE treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                      • Supported by the indexed evidence.
                                      • specimen category excludes: Biofluid — Insufficient evidence
                                        • The required value is not reported.
                                        • Paired blood biopsy PRE treatment pair and rep 6 paired blood biopsy PRE treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                        • Paired blood biopsy PRE treatment pair and rep 6 paired blood biopsy PRE treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                      Source metadata
                                      Source name
                                      paired blood biopsy PRE treatment pair and rep 6
                                      Characteristics
                                      age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 6
                                      Description
                                      Not reported
                                      Indexed organism evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Indexed assay evidence
                                      INFERRED · PARENT_INHERITED: Not reported
                                      Source
                                      GEO
                                      Original indexed metadata
                                      sample_accession: GSM1899809
                                      sample_title: Paired blood biopsy PRE treatment pair and rep 6
                                      source_name: paired blood biopsy PRE treatment pair and rep 6
                                      characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 6

                                      GSM1899810

                                      Uncertain

                                      Paired blood biopsy PRE treatment pair and rep 7

                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                      Requirements and decision evidence
                                      • organism: Homo sapiens — Insufficient evidence
                                        • The required value is not reported.
                                        • assay type: bulk RNA-seq — Insufficient evidence
                                          • The required value is not reported.
                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                            • The required value is not reported.
                                            • Paired blood biopsy PRE treatment pair and rep 7 paired blood biopsy PRE treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                            • Paired blood biopsy PRE treatment pair and rep 7 paired blood biopsy PRE treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                            • Supported by the indexed evidence.
                                            • specimen category excludes: Biofluid — Insufficient evidence
                                              • The required value is not reported.
                                              • Paired blood biopsy PRE treatment pair and rep 7 paired blood biopsy PRE treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                              • Paired blood biopsy PRE treatment pair and rep 7 paired blood biopsy PRE treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                            Source metadata
                                            Source name
                                            paired blood biopsy PRE treatment pair and rep 7
                                            Characteristics
                                            age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 7
                                            Description
                                            Not reported
                                            Indexed organism evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Indexed assay evidence
                                            INFERRED · PARENT_INHERITED: Not reported
                                            Source
                                            GEO
                                            Original indexed metadata
                                            sample_accession: GSM1899810
                                            sample_title: Paired blood biopsy PRE treatment pair and rep 7
                                            source_name: paired blood biopsy PRE treatment pair and rep 7
                                            characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 7

                                            GSM1899811

                                            Uncertain

                                            Paired blood biopsy PRE treatment pair and rep 8

                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                            Requirements and decision evidence
                                            • organism: Homo sapiens — Insufficient evidence
                                              • The required value is not reported.
                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                • The required value is not reported.
                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                  • The required value is not reported.
                                                  • Paired blood biopsy PRE treatment pair and rep 8 paired blood biopsy PRE treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                  • Paired blood biopsy PRE treatment pair and rep 8 paired blood biopsy PRE treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                  • Supported by the indexed evidence.
                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                    • The required value is not reported.
                                                    • Paired blood biopsy PRE treatment pair and rep 8 paired blood biopsy PRE treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                    • Paired blood biopsy PRE treatment pair and rep 8 paired blood biopsy PRE treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                  Source metadata
                                                  Source name
                                                  paired blood biopsy PRE treatment pair and rep 8
                                                  Characteristics
                                                  age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 8
                                                  Description
                                                  Not reported
                                                  Indexed organism evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Indexed assay evidence
                                                  INFERRED · PARENT_INHERITED: Not reported
                                                  Source
                                                  GEO
                                                  Original indexed metadata
                                                  sample_accession: GSM1899811
                                                  sample_title: Paired blood biopsy PRE treatment pair and rep 8
                                                  source_name: paired blood biopsy PRE treatment pair and rep 8
                                                  characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 8

                                                  GSM1899812

                                                  Uncertain

                                                  Paired blood biopsy PRE treatment pair and rep 9

                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                  Requirements and decision evidence
                                                  • organism: Homo sapiens — Insufficient evidence
                                                    • The required value is not reported.
                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                      • The required value is not reported.
                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                        • The required value is not reported.
                                                        • Paired blood biopsy PRE treatment pair and rep 9 paired blood biopsy PRE treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                        • Paired blood biopsy PRE treatment pair and rep 9 paired blood biopsy PRE treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                        • Supported by the indexed evidence.
                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                          • The required value is not reported.
                                                          • Paired blood biopsy PRE treatment pair and rep 9 paired blood biopsy PRE treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                          • Paired blood biopsy PRE treatment pair and rep 9 paired blood biopsy PRE treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: n...
                                                        Source metadata
                                                        Source name
                                                        paired blood biopsy PRE treatment pair and rep 9
                                                        Characteristics
                                                        age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 9
                                                        Description
                                                        Not reported
                                                        Indexed organism evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Indexed assay evidence
                                                        INFERRED · PARENT_INHERITED: Not reported
                                                        Source
                                                        GEO
                                                        Original indexed metadata
                                                        sample_accession: GSM1899812
                                                        sample_title: Paired blood biopsy PRE treatment pair and rep 9
                                                        source_name: paired blood biopsy PRE treatment pair and rep 9
                                                        characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 9

                                                        GSM1899813

                                                        Uncertain

                                                        Paired blood biopsy PRE treatment pair and rep 10

                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                        Requirements and decision evidence
                                                        • organism: Homo sapiens — Insufficient evidence
                                                          • The required value is not reported.
                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                            • The required value is not reported.
                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                              • The required value is not reported.
                                                              • Paired blood biopsy PRE treatment pair and rep 10 paired blood biopsy PRE treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                              • Paired blood biopsy PRE treatment pair and rep 10 paired blood biopsy PRE treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                              • Supported by the indexed evidence.
                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                • The required value is not reported.
                                                                • Paired blood biopsy PRE treatment pair and rep 10 paired blood biopsy PRE treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                • Paired blood biopsy PRE treatment pair and rep 10 paired blood biopsy PRE treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                              Source metadata
                                                              Source name
                                                              paired blood biopsy PRE treatment pair and rep 10
                                                              Characteristics
                                                              age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 10
                                                              Description
                                                              Not reported
                                                              Indexed organism evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Indexed assay evidence
                                                              INFERRED · PARENT_INHERITED: Not reported
                                                              Source
                                                              GEO
                                                              Original indexed metadata
                                                              sample_accession: GSM1899813
                                                              sample_title: Paired blood biopsy PRE treatment pair and rep 10
                                                              source_name: paired blood biopsy PRE treatment pair and rep 10
                                                              characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 10

                                                              GSM1899814

                                                              Uncertain

                                                              Paired blood biopsy PRE treatment pair and rep 11

                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                              Requirements and decision evidence
                                                              • organism: Homo sapiens — Insufficient evidence
                                                                • The required value is not reported.
                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                  • The required value is not reported.
                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                    • The required value is not reported.
                                                                    • Paired blood biopsy PRE treatment pair and rep 11 paired blood biopsy PRE treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                    • Paired blood biopsy PRE treatment pair and rep 11 paired blood biopsy PRE treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                    • Supported by the indexed evidence.
                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • Paired blood biopsy PRE treatment pair and rep 11 paired blood biopsy PRE treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                      • Paired blood biopsy PRE treatment pair and rep 11 paired blood biopsy PRE treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                    Source metadata
                                                                    Source name
                                                                    paired blood biopsy PRE treatment pair and rep 11
                                                                    Characteristics
                                                                    age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 11
                                                                    Description
                                                                    Not reported
                                                                    Indexed organism evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Indexed assay evidence
                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                    Source
                                                                    GEO
                                                                    Original indexed metadata
                                                                    sample_accession: GSM1899814
                                                                    sample_title: Paired blood biopsy PRE treatment pair and rep 11
                                                                    source_name: paired blood biopsy PRE treatment pair and rep 11
                                                                    characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 11

                                                                    GSM1899815

                                                                    Uncertain

                                                                    Paired blood biopsy PRE treatment pair and rep 12

                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                    Requirements and decision evidence
                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                      • The required value is not reported.
                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                        • The required value is not reported.
                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                          • The required value is not reported.
                                                                          • Paired blood biopsy PRE treatment pair and rep 12 paired blood biopsy PRE treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                          • Paired blood biopsy PRE treatment pair and rep 12 paired blood biopsy PRE treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                          • Supported by the indexed evidence.
                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • Paired blood biopsy PRE treatment pair and rep 12 paired blood biopsy PRE treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                            • Paired blood biopsy PRE treatment pair and rep 12 paired blood biopsy PRE treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                          Source metadata
                                                                          Source name
                                                                          paired blood biopsy PRE treatment pair and rep 12
                                                                          Characteristics
                                                                          age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 12
                                                                          Description
                                                                          Not reported
                                                                          Indexed organism evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Indexed assay evidence
                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                          Source
                                                                          GEO
                                                                          Original indexed metadata
                                                                          sample_accession: GSM1899815
                                                                          sample_title: Paired blood biopsy PRE treatment pair and rep 12
                                                                          source_name: paired blood biopsy PRE treatment pair and rep 12
                                                                          characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: none; time point: pre-treatment; participant: 12

                                                                          GSM1899816

                                                                          Uncertain

                                                                          Paired blood biopsy POST treatment pair and rep 1

                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                          Requirements and decision evidence
                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                            • The required value is not reported.
                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                              • The required value is not reported.
                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                • The required value is not reported.
                                                                                • Paired blood biopsy POST treatment pair and rep 1 paired blood biopsy Post treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                • Paired blood biopsy POST treatment pair and rep 1 paired blood biopsy Post treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                • Supported by the indexed evidence.
                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • Paired blood biopsy POST treatment pair and rep 1 paired blood biopsy Post treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                  • Paired blood biopsy POST treatment pair and rep 1 paired blood biopsy Post treatment pair and rep 1 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                Source metadata
                                                                                Source name
                                                                                paired blood biopsy Post treatment pair and rep 1
                                                                                Characteristics
                                                                                age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 1
                                                                                Description
                                                                                Not reported
                                                                                Indexed organism evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Indexed assay evidence
                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                Source
                                                                                GEO
                                                                                Original indexed metadata
                                                                                sample_accession: GSM1899816
                                                                                sample_title: Paired blood biopsy POST treatment pair and rep 1
                                                                                source_name: paired blood biopsy Post treatment pair and rep 1
                                                                                characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 1

                                                                                GSM1899817

                                                                                Uncertain

                                                                                Paired blood biopsy POST treatment pair and rep 2

                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                Requirements and decision evidence
                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                  • The required value is not reported.
                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                    • The required value is not reported.
                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                      • The required value is not reported.
                                                                                      • Paired blood biopsy POST treatment pair and rep 2 paired blood biopsy Post treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                      • Paired blood biopsy POST treatment pair and rep 2 paired blood biopsy Post treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                      • Supported by the indexed evidence.
                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • Paired blood biopsy POST treatment pair and rep 2 paired blood biopsy Post treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                        • Paired blood biopsy POST treatment pair and rep 2 paired blood biopsy Post treatment pair and rep 2 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                      Source metadata
                                                                                      Source name
                                                                                      paired blood biopsy Post treatment pair and rep 2
                                                                                      Characteristics
                                                                                      age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 2
                                                                                      Description
                                                                                      Not reported
                                                                                      Indexed organism evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Indexed assay evidence
                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                      Source
                                                                                      GEO
                                                                                      Original indexed metadata
                                                                                      sample_accession: GSM1899817
                                                                                      sample_title: Paired blood biopsy POST treatment pair and rep 2
                                                                                      source_name: paired blood biopsy Post treatment pair and rep 2
                                                                                      characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 2

                                                                                      GSM1899818

                                                                                      Uncertain

                                                                                      Paired blood biopsy POST treatment pair and rep 3

                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                      Requirements and decision evidence
                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                        • The required value is not reported.
                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                          • The required value is not reported.
                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                            • The required value is not reported.
                                                                                            • Paired blood biopsy POST treatment pair and rep 3 paired blood biopsy Post treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                            • Paired blood biopsy POST treatment pair and rep 3 paired blood biopsy Post treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                            • Supported by the indexed evidence.
                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • Paired blood biopsy POST treatment pair and rep 3 paired blood biopsy Post treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                              • Paired blood biopsy POST treatment pair and rep 3 paired blood biopsy Post treatment pair and rep 3 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                            Source metadata
                                                                                            Source name
                                                                                            paired blood biopsy Post treatment pair and rep 3
                                                                                            Characteristics
                                                                                            age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 3
                                                                                            Description
                                                                                            Not reported
                                                                                            Indexed organism evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Indexed assay evidence
                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                            Source
                                                                                            GEO
                                                                                            Original indexed metadata
                                                                                            sample_accession: GSM1899818
                                                                                            sample_title: Paired blood biopsy POST treatment pair and rep 3
                                                                                            source_name: paired blood biopsy Post treatment pair and rep 3
                                                                                            characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 3

                                                                                            GSM1899819

                                                                                            Uncertain

                                                                                            Paired blood biopsy POST treatment pair and rep 4

                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                            Requirements and decision evidence
                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                              • The required value is not reported.
                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                • The required value is not reported.
                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                  • The required value is not reported.
                                                                                                  • Paired blood biopsy POST treatment pair and rep 4 paired blood biopsy Post treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                  • Paired blood biopsy POST treatment pair and rep 4 paired blood biopsy Post treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                  • Supported by the indexed evidence.
                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • Paired blood biopsy POST treatment pair and rep 4 paired blood biopsy Post treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                    • Paired blood biopsy POST treatment pair and rep 4 paired blood biopsy Post treatment pair and rep 4 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                  Source metadata
                                                                                                  Source name
                                                                                                  paired blood biopsy Post treatment pair and rep 4
                                                                                                  Characteristics
                                                                                                  age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 4
                                                                                                  Description
                                                                                                  Not reported
                                                                                                  Indexed organism evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Indexed assay evidence
                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                  Source
                                                                                                  GEO
                                                                                                  Original indexed metadata
                                                                                                  sample_accession: GSM1899819
                                                                                                  sample_title: Paired blood biopsy POST treatment pair and rep 4
                                                                                                  source_name: paired blood biopsy Post treatment pair and rep 4
                                                                                                  characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 4

                                                                                                  GSM1899820

                                                                                                  Uncertain

                                                                                                  Paired blood biopsy POST treatment pair and rep 5

                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                  Requirements and decision evidence
                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                    • The required value is not reported.
                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                      • The required value is not reported.
                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                        • The required value is not reported.
                                                                                                        • Paired blood biopsy POST treatment pair and rep 5 paired blood biopsy Post treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                        • Paired blood biopsy POST treatment pair and rep 5 paired blood biopsy Post treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                        • Supported by the indexed evidence.
                                                                                                        • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • Paired blood biopsy POST treatment pair and rep 5 paired blood biopsy Post treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                          • Paired blood biopsy POST treatment pair and rep 5 paired blood biopsy Post treatment pair and rep 5 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                        Source metadata
                                                                                                        Source name
                                                                                                        paired blood biopsy Post treatment pair and rep 5
                                                                                                        Characteristics
                                                                                                        age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 5
                                                                                                        Description
                                                                                                        Not reported
                                                                                                        Indexed organism evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Indexed assay evidence
                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                        Source
                                                                                                        GEO
                                                                                                        Original indexed metadata
                                                                                                        sample_accession: GSM1899820
                                                                                                        sample_title: Paired blood biopsy POST treatment pair and rep 5
                                                                                                        source_name: paired blood biopsy Post treatment pair and rep 5
                                                                                                        characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 5

                                                                                                        GSM1899821

                                                                                                        Uncertain

                                                                                                        Paired blood biopsy POST treatment pair and rep 6

                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                        Requirements and decision evidence
                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                          • The required value is not reported.
                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                            • The required value is not reported.
                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                              • The required value is not reported.
                                                                                                              • Paired blood biopsy POST treatment pair and rep 6 paired blood biopsy Post treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                              • Paired blood biopsy POST treatment pair and rep 6 paired blood biopsy Post treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                              • Supported by the indexed evidence.
                                                                                                              • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • Paired blood biopsy POST treatment pair and rep 6 paired blood biopsy Post treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                • Paired blood biopsy POST treatment pair and rep 6 paired blood biopsy Post treatment pair and rep 6 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                              Source metadata
                                                                                                              Source name
                                                                                                              paired blood biopsy Post treatment pair and rep 6
                                                                                                              Characteristics
                                                                                                              age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 6
                                                                                                              Description
                                                                                                              Not reported
                                                                                                              Indexed organism evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Indexed assay evidence
                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                              Source
                                                                                                              GEO
                                                                                                              Original indexed metadata
                                                                                                              sample_accession: GSM1899821
                                                                                                              sample_title: Paired blood biopsy POST treatment pair and rep 6
                                                                                                              source_name: paired blood biopsy Post treatment pair and rep 6
                                                                                                              characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 6

                                                                                                              GSM1899822

                                                                                                              Uncertain

                                                                                                              Paired blood biopsy POST treatment pair and rep 7

                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                              Requirements and decision evidence
                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                • The required value is not reported.
                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                  • The required value is not reported.
                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                    • The required value is not reported.
                                                                                                                    • Paired blood biopsy POST treatment pair and rep 7 paired blood biopsy Post treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                    • Paired blood biopsy POST treatment pair and rep 7 paired blood biopsy Post treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                    • Supported by the indexed evidence.
                                                                                                                    • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • Paired blood biopsy POST treatment pair and rep 7 paired blood biopsy Post treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                      • Paired blood biopsy POST treatment pair and rep 7 paired blood biopsy Post treatment pair and rep 7 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                    Source metadata
                                                                                                                    Source name
                                                                                                                    paired blood biopsy Post treatment pair and rep 7
                                                                                                                    Characteristics
                                                                                                                    age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 7
                                                                                                                    Description
                                                                                                                    Not reported
                                                                                                                    Indexed organism evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Indexed assay evidence
                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                    Source
                                                                                                                    GEO
                                                                                                                    Original indexed metadata
                                                                                                                    sample_accession: GSM1899822
                                                                                                                    sample_title: Paired blood biopsy POST treatment pair and rep 7
                                                                                                                    source_name: paired blood biopsy Post treatment pair and rep 7
                                                                                                                    characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 7

                                                                                                                    GSM1899823

                                                                                                                    Uncertain

                                                                                                                    Paired blood biopsy POST treatment pair and rep 8

                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                    Requirements and decision evidence
                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                      • The required value is not reported.
                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                        • The required value is not reported.
                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                          • The required value is not reported.
                                                                                                                          • Paired blood biopsy POST treatment pair and rep 8 paired blood biopsy Post treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                          • Paired blood biopsy POST treatment pair and rep 8 paired blood biopsy Post treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                          • Supported by the indexed evidence.
                                                                                                                          • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • Paired blood biopsy POST treatment pair and rep 8 paired blood biopsy Post treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                            • Paired blood biopsy POST treatment pair and rep 8 paired blood biopsy Post treatment pair and rep 8 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                          Source metadata
                                                                                                                          Source name
                                                                                                                          paired blood biopsy Post treatment pair and rep 8
                                                                                                                          Characteristics
                                                                                                                          age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 8
                                                                                                                          Description
                                                                                                                          Not reported
                                                                                                                          Indexed organism evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Indexed assay evidence
                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                          Source
                                                                                                                          GEO
                                                                                                                          Original indexed metadata
                                                                                                                          sample_accession: GSM1899823
                                                                                                                          sample_title: Paired blood biopsy POST treatment pair and rep 8
                                                                                                                          source_name: paired blood biopsy Post treatment pair and rep 8
                                                                                                                          characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 8

                                                                                                                          GSM1899824

                                                                                                                          Uncertain

                                                                                                                          Paired blood biopsy POST treatment pair and rep 9

                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                          Requirements and decision evidence
                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                            • The required value is not reported.
                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                              • The required value is not reported.
                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                • The required value is not reported.
                                                                                                                                • Paired blood biopsy POST treatment pair and rep 9 paired blood biopsy Post treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                                • Paired blood biopsy POST treatment pair and rep 9 paired blood biopsy Post treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • Paired blood biopsy POST treatment pair and rep 9 paired blood biopsy Post treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                                  • Paired blood biopsy POST treatment pair and rep 9 paired blood biopsy Post treatment pair and rep 9 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment:...
                                                                                                                                Source metadata
                                                                                                                                Source name
                                                                                                                                paired blood biopsy Post treatment pair and rep 9
                                                                                                                                Characteristics
                                                                                                                                age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 9
                                                                                                                                Description
                                                                                                                                Not reported
                                                                                                                                Indexed organism evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Indexed assay evidence
                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                Source
                                                                                                                                GEO
                                                                                                                                Original indexed metadata
                                                                                                                                sample_accession: GSM1899824
                                                                                                                                sample_title: Paired blood biopsy POST treatment pair and rep 9
                                                                                                                                source_name: paired blood biopsy Post treatment pair and rep 9
                                                                                                                                characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 9

                                                                                                                                GSM1899825

                                                                                                                                Uncertain

                                                                                                                                Paired blood biopsy POST treatment pair and rep 10

                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                Requirements and decision evidence
                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                  • The required value is not reported.
                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                    • The required value is not reported.
                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                      • The required value is not reported.
                                                                                                                                      • Paired blood biopsy POST treatment pair and rep 10 paired blood biopsy Post treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                      • Paired blood biopsy POST treatment pair and rep 10 paired blood biopsy Post treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                      • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • Paired blood biopsy POST treatment pair and rep 10 paired blood biopsy Post treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                        • Paired blood biopsy POST treatment pair and rep 10 paired blood biopsy Post treatment pair and rep 10 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                      Source metadata
                                                                                                                                      Source name
                                                                                                                                      paired blood biopsy Post treatment pair and rep 10
                                                                                                                                      Characteristics
                                                                                                                                      age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 10
                                                                                                                                      Description
                                                                                                                                      Not reported
                                                                                                                                      Indexed organism evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Indexed assay evidence
                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                      Source
                                                                                                                                      GEO
                                                                                                                                      Original indexed metadata
                                                                                                                                      sample_accession: GSM1899825
                                                                                                                                      sample_title: Paired blood biopsy POST treatment pair and rep 10
                                                                                                                                      source_name: paired blood biopsy Post treatment pair and rep 10
                                                                                                                                      characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 10

                                                                                                                                      GSM1899826

                                                                                                                                      Uncertain

                                                                                                                                      Paired blood biopsy POST treatment pair and rep 11

                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                      Requirements and decision evidence
                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                        • The required value is not reported.
                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                          • The required value is not reported.
                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                            • The required value is not reported.
                                                                                                                                            • Paired blood biopsy POST treatment pair and rep 11 paired blood biopsy Post treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                            • Paired blood biopsy POST treatment pair and rep 11 paired blood biopsy Post treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                            • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • Paired blood biopsy POST treatment pair and rep 11 paired blood biopsy Post treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                              • Paired blood biopsy POST treatment pair and rep 11 paired blood biopsy Post treatment pair and rep 11 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                            Source metadata
                                                                                                                                            Source name
                                                                                                                                            paired blood biopsy Post treatment pair and rep 11
                                                                                                                                            Characteristics
                                                                                                                                            age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 11
                                                                                                                                            Description
                                                                                                                                            Not reported
                                                                                                                                            Indexed organism evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Indexed assay evidence
                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                            Source
                                                                                                                                            GEO
                                                                                                                                            Original indexed metadata
                                                                                                                                            sample_accession: GSM1899826
                                                                                                                                            sample_title: Paired blood biopsy POST treatment pair and rep 11
                                                                                                                                            source_name: paired blood biopsy Post treatment pair and rep 11
                                                                                                                                            characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 11

                                                                                                                                            GSM1899827

                                                                                                                                            Uncertain

                                                                                                                                            Paired blood biopsy POST treatment pair and rep 12

                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. specimen category excludes: Biofluid — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                            Requirements and decision evidence
                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                              • The required value is not reported.
                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                • The required value is not reported.
                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                  • The required value is not reported.
                                                                                                                                                  • Paired blood biopsy POST treatment pair and rep 12 paired blood biopsy Post treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                                  • Paired blood biopsy POST treatment pair and rep 12 paired blood biopsy Post treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                  • specimen category excludes: Biofluid — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • Paired blood biopsy POST treatment pair and rep 12 paired blood biopsy Post treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                                    • Paired blood biopsy POST treatment pair and rep 12 paired blood biopsy Post treatment pair and rep 12 age: adult; disease state: advanced liver fibrosis; tissue: blood; treatmen...
                                                                                                                                                  Source metadata
                                                                                                                                                  Source name
                                                                                                                                                  paired blood biopsy Post treatment pair and rep 12
                                                                                                                                                  Characteristics
                                                                                                                                                  age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 12
                                                                                                                                                  Description
                                                                                                                                                  Not reported
                                                                                                                                                  Indexed organism evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Indexed assay evidence
                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                  Source
                                                                                                                                                  GEO
                                                                                                                                                  Original indexed metadata
                                                                                                                                                  sample_accession: GSM1899827
                                                                                                                                                  sample_title: Paired blood biopsy POST treatment pair and rep 12
                                                                                                                                                  source_name: paired blood biopsy Post treatment pair and rep 12
                                                                                                                                                  characteristics: age: adult; disease state: advanced liver fibrosis; tissue: blood; treatment: simtuzumab; time point: post-treatment; participant: 12

                                                                                                                                                  GSM1899828

                                                                                                                                                  Uncertain

                                                                                                                                                  Paired liver PRE treatment pair and rep 1

                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                    • The required value is not reported.
                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                      • The required value is not reported.
                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                        • The required value is not reported.
                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                          • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                            Source metadata
                                                                                                                                                            Source name
                                                                                                                                                            paired liver PRE treatment pair and rep 1
                                                                                                                                                            Characteristics
                                                                                                                                                            age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 1
                                                                                                                                                            Description
                                                                                                                                                            Not reported
                                                                                                                                                            Indexed organism evidence
                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                            Indexed assay evidence
                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                            Source
                                                                                                                                                            GEO
                                                                                                                                                            Original indexed metadata
                                                                                                                                                            sample_accession: GSM1899828
                                                                                                                                                            sample_title: Paired liver PRE treatment pair and rep 1
                                                                                                                                                            source_name: paired liver PRE treatment pair and rep 1
                                                                                                                                                            characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 1

                                                                                                                                                            GSM1899829

                                                                                                                                                            Uncertain

                                                                                                                                                            Paired liver PRE treatment pair and rep 2

                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                              • The required value is not reported.
                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                    • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                      Source metadata
                                                                                                                                                                      Source name
                                                                                                                                                                      paired liver PRE treatment pair and rep 2
                                                                                                                                                                      Characteristics
                                                                                                                                                                      age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 2
                                                                                                                                                                      Description
                                                                                                                                                                      Not reported
                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                      Source
                                                                                                                                                                      GEO
                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                      sample_accession: GSM1899829
                                                                                                                                                                      sample_title: Paired liver PRE treatment pair and rep 2
                                                                                                                                                                      source_name: paired liver PRE treatment pair and rep 2
                                                                                                                                                                      characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 2

                                                                                                                                                                      GSM1899830

                                                                                                                                                                      Uncertain

                                                                                                                                                                      Paired liver PRE treatment pair and rep 3

                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                              • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                Source metadata
                                                                                                                                                                                Source name
                                                                                                                                                                                paired liver PRE treatment pair and rep 3
                                                                                                                                                                                Characteristics
                                                                                                                                                                                age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 3
                                                                                                                                                                                Description
                                                                                                                                                                                Not reported
                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                Source
                                                                                                                                                                                GEO
                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                sample_accession: GSM1899830
                                                                                                                                                                                sample_title: Paired liver PRE treatment pair and rep 3
                                                                                                                                                                                source_name: paired liver PRE treatment pair and rep 3
                                                                                                                                                                                characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 3

                                                                                                                                                                                GSM1899831

                                                                                                                                                                                Uncertain

                                                                                                                                                                                Paired liver PRE treatment pair and rep 4

                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                        • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                          Source metadata
                                                                                                                                                                                          Source name
                                                                                                                                                                                          paired liver PRE treatment pair and rep 4
                                                                                                                                                                                          Characteristics
                                                                                                                                                                                          age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 4
                                                                                                                                                                                          Description
                                                                                                                                                                                          Not reported
                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                          Source
                                                                                                                                                                                          GEO
                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                          sample_accession: GSM1899831
                                                                                                                                                                                          sample_title: Paired liver PRE treatment pair and rep 4
                                                                                                                                                                                          source_name: paired liver PRE treatment pair and rep 4
                                                                                                                                                                                          characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 4

                                                                                                                                                                                          GSM1899832

                                                                                                                                                                                          Uncertain

                                                                                                                                                                                          Paired liver PRE treatment pair and rep 5

                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                  • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                    Source name
                                                                                                                                                                                                    paired liver PRE treatment pair and rep 5
                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                    age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 5
                                                                                                                                                                                                    Description
                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                    Source
                                                                                                                                                                                                    GEO
                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                    sample_accession: GSM1899832
                                                                                                                                                                                                    sample_title: Paired liver PRE treatment pair and rep 5
                                                                                                                                                                                                    source_name: paired liver PRE treatment pair and rep 5
                                                                                                                                                                                                    characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 5

                                                                                                                                                                                                    GSM1899833

                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                    Paired liver PRE treatment pair and rep 6

                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                            • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                              Source name
                                                                                                                                                                                                              paired liver PRE treatment pair and rep 6
                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                              age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 6
                                                                                                                                                                                                              Description
                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                              Source
                                                                                                                                                                                                              GEO
                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                              sample_accession: GSM1899833
                                                                                                                                                                                                              sample_title: Paired liver PRE treatment pair and rep 6
                                                                                                                                                                                                              source_name: paired liver PRE treatment pair and rep 6
                                                                                                                                                                                                              characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 6

                                                                                                                                                                                                              GSM1899834

                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                              Paired liver PRE treatment pair and rep 7

                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                        paired liver PRE treatment pair and rep 7
                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                        age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 7
                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                        sample_accession: GSM1899834
                                                                                                                                                                                                                        sample_title: Paired liver PRE treatment pair and rep 7
                                                                                                                                                                                                                        source_name: paired liver PRE treatment pair and rep 7
                                                                                                                                                                                                                        characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 7

                                                                                                                                                                                                                        GSM1899835

                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                        Paired liver PRE treatment pair and rep 8

                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                  paired liver PRE treatment pair and rep 8
                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                  age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 8
                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                  sample_accession: GSM1899835
                                                                                                                                                                                                                                  sample_title: Paired liver PRE treatment pair and rep 8
                                                                                                                                                                                                                                  source_name: paired liver PRE treatment pair and rep 8
                                                                                                                                                                                                                                  characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 8

                                                                                                                                                                                                                                  GSM1899836

                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                  Paired liver PRE treatment pair and rep 9

                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                            paired liver PRE treatment pair and rep 9
                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                            age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 9
                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                            sample_accession: GSM1899836
                                                                                                                                                                                                                                            sample_title: Paired liver PRE treatment pair and rep 9
                                                                                                                                                                                                                                            source_name: paired liver PRE treatment pair and rep 9
                                                                                                                                                                                                                                            characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 9

                                                                                                                                                                                                                                            GSM1899837

                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                            Paired liver PRE treatment pair and rep 10

                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                      paired liver PRE treatment pair and rep 10
                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                      age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 10
                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                      sample_accession: GSM1899837
                                                                                                                                                                                                                                                      sample_title: Paired liver PRE treatment pair and rep 10
                                                                                                                                                                                                                                                      source_name: paired liver PRE treatment pair and rep 10
                                                                                                                                                                                                                                                      characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 10

                                                                                                                                                                                                                                                      GSM1899838

                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                      Paired liver PRE treatment pair and rep 11

                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                paired liver PRE treatment pair and rep 11
                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 11
                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                sample_accession: GSM1899838
                                                                                                                                                                                                                                                                sample_title: Paired liver PRE treatment pair and rep 11
                                                                                                                                                                                                                                                                source_name: paired liver PRE treatment pair and rep 11
                                                                                                                                                                                                                                                                characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 11

                                                                                                                                                                                                                                                                GSM1899839

                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                Paired liver PRE treatment pair and rep 12

                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                          paired liver PRE treatment pair and rep 12
                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                          age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 12
                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                          sample_accession: GSM1899839
                                                                                                                                                                                                                                                                          sample_title: Paired liver PRE treatment pair and rep 12
                                                                                                                                                                                                                                                                          source_name: paired liver PRE treatment pair and rep 12
                                                                                                                                                                                                                                                                          characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: none; time point: pre-treatment; participant: 12

                                                                                                                                                                                                                                                                          GSM1899840

                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                          Paired liver POST treatment pair and rep 1

                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                    paired liver Post treatment pair and rep 1
                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                    age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 1
                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                    sample_accession: GSM1899840
                                                                                                                                                                                                                                                                                    sample_title: Paired liver POST treatment pair and rep 1
                                                                                                                                                                                                                                                                                    source_name: paired liver Post treatment pair and rep 1
                                                                                                                                                                                                                                                                                    characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 1

                                                                                                                                                                                                                                                                                    GSM1899841

                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                    Paired liver POST treatment pair and rep 2

                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                              paired liver Post treatment pair and rep 2
                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                              age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 2
                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                              sample_accession: GSM1899841
                                                                                                                                                                                                                                                                                              sample_title: Paired liver POST treatment pair and rep 2
                                                                                                                                                                                                                                                                                              source_name: paired liver Post treatment pair and rep 2
                                                                                                                                                                                                                                                                                              characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 2

                                                                                                                                                                                                                                                                                              GSM1899842

                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                              Paired liver POST treatment pair and rep 3

                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                        paired liver Post treatment pair and rep 3
                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                        age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 3
                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                        sample_accession: GSM1899842
                                                                                                                                                                                                                                                                                                        sample_title: Paired liver POST treatment pair and rep 3
                                                                                                                                                                                                                                                                                                        source_name: paired liver Post treatment pair and rep 3
                                                                                                                                                                                                                                                                                                        characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 3

                                                                                                                                                                                                                                                                                                        GSM1899843

                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                        Paired liver POST treatment pair and rep 4

                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                  paired liver Post treatment pair and rep 4
                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                  age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 4
                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                  sample_accession: GSM1899843
                                                                                                                                                                                                                                                                                                                  sample_title: Paired liver POST treatment pair and rep 4
                                                                                                                                                                                                                                                                                                                  source_name: paired liver Post treatment pair and rep 4
                                                                                                                                                                                                                                                                                                                  characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 4

                                                                                                                                                                                                                                                                                                                  GSM1899844

                                                                                                                                                                                                                                                                                                                  Uncertain

                                                                                                                                                                                                                                                                                                                  Paired liver POST treatment pair and rep 5

                                                                                                                                                                                                                                                                                                                  Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                  Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                  • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                    • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                      • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                        • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                          • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                            Source metadata
                                                                                                                                                                                                                                                                                                                            Source name
                                                                                                                                                                                                                                                                                                                            paired liver Post treatment pair and rep 5
                                                                                                                                                                                                                                                                                                                            Characteristics
                                                                                                                                                                                                                                                                                                                            age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 5
                                                                                                                                                                                                                                                                                                                            Description
                                                                                                                                                                                                                                                                                                                            Not reported
                                                                                                                                                                                                                                                                                                                            Indexed organism evidence
                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                            Indexed assay evidence
                                                                                                                                                                                                                                                                                                                            INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                            Source
                                                                                                                                                                                                                                                                                                                            GEO
                                                                                                                                                                                                                                                                                                                            Original indexed metadata
                                                                                                                                                                                                                                                                                                                            sample_accession: GSM1899844
                                                                                                                                                                                                                                                                                                                            sample_title: Paired liver POST treatment pair and rep 5
                                                                                                                                                                                                                                                                                                                            source_name: paired liver Post treatment pair and rep 5
                                                                                                                                                                                                                                                                                                                            characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 5

                                                                                                                                                                                                                                                                                                                            GSM1899845

                                                                                                                                                                                                                                                                                                                            Uncertain

                                                                                                                                                                                                                                                                                                                            Paired liver POST treatment pair and rep 6

                                                                                                                                                                                                                                                                                                                            Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                            Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                            • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                              • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                  • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                    • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                      Source metadata
                                                                                                                                                                                                                                                                                                                                      Source name
                                                                                                                                                                                                                                                                                                                                      paired liver Post treatment pair and rep 6
                                                                                                                                                                                                                                                                                                                                      Characteristics
                                                                                                                                                                                                                                                                                                                                      age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 6
                                                                                                                                                                                                                                                                                                                                      Description
                                                                                                                                                                                                                                                                                                                                      Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                      INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                      Source
                                                                                                                                                                                                                                                                                                                                      GEO
                                                                                                                                                                                                                                                                                                                                      Original indexed metadata
                                                                                                                                                                                                                                                                                                                                      sample_accession: GSM1899845
                                                                                                                                                                                                                                                                                                                                      sample_title: Paired liver POST treatment pair and rep 6
                                                                                                                                                                                                                                                                                                                                      source_name: paired liver Post treatment pair and rep 6
                                                                                                                                                                                                                                                                                                                                      characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 6

                                                                                                                                                                                                                                                                                                                                      GSM1899846

                                                                                                                                                                                                                                                                                                                                      Uncertain

                                                                                                                                                                                                                                                                                                                                      Paired liver POST treatment pair and rep 7

                                                                                                                                                                                                                                                                                                                                      Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                      Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                      • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                        • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                          • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                            • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                              • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                Source metadata
                                                                                                                                                                                                                                                                                                                                                Source name
                                                                                                                                                                                                                                                                                                                                                paired liver Post treatment pair and rep 7
                                                                                                                                                                                                                                                                                                                                                Characteristics
                                                                                                                                                                                                                                                                                                                                                age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 7
                                                                                                                                                                                                                                                                                                                                                Description
                                                                                                                                                                                                                                                                                                                                                Not reported
                                                                                                                                                                                                                                                                                                                                                Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                Source
                                                                                                                                                                                                                                                                                                                                                GEO
                                                                                                                                                                                                                                                                                                                                                Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                sample_accession: GSM1899846
                                                                                                                                                                                                                                                                                                                                                sample_title: Paired liver POST treatment pair and rep 7
                                                                                                                                                                                                                                                                                                                                                source_name: paired liver Post treatment pair and rep 7
                                                                                                                                                                                                                                                                                                                                                characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 7

                                                                                                                                                                                                                                                                                                                                                GSM1899847

                                                                                                                                                                                                                                                                                                                                                Uncertain

                                                                                                                                                                                                                                                                                                                                                Paired liver POST treatment pair and rep 8

                                                                                                                                                                                                                                                                                                                                                Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                  • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                    • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                      • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                        • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                                          • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                          Source metadata
                                                                                                                                                                                                                                                                                                                                                          Source name
                                                                                                                                                                                                                                                                                                                                                          paired liver Post treatment pair and rep 8
                                                                                                                                                                                                                                                                                                                                                          Characteristics
                                                                                                                                                                                                                                                                                                                                                          age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 8
                                                                                                                                                                                                                                                                                                                                                          Description
                                                                                                                                                                                                                                                                                                                                                          Not reported
                                                                                                                                                                                                                                                                                                                                                          Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                          Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                          INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                          Source
                                                                                                                                                                                                                                                                                                                                                          GEO
                                                                                                                                                                                                                                                                                                                                                          Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                          sample_accession: GSM1899847
                                                                                                                                                                                                                                                                                                                                                          sample_title: Paired liver POST treatment pair and rep 8
                                                                                                                                                                                                                                                                                                                                                          source_name: paired liver Post treatment pair and rep 8
                                                                                                                                                                                                                                                                                                                                                          characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 8

                                                                                                                                                                                                                                                                                                                                                          GSM1899848

                                                                                                                                                                                                                                                                                                                                                          Uncertain

                                                                                                                                                                                                                                                                                                                                                          Paired liver POST treatment pair and rep 9

                                                                                                                                                                                                                                                                                                                                                          Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                          Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                          • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                            • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                              • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                  • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                    • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                    Source metadata
                                                                                                                                                                                                                                                                                                                                                                    Source name
                                                                                                                                                                                                                                                                                                                                                                    paired liver Post treatment pair and rep 9
                                                                                                                                                                                                                                                                                                                                                                    Characteristics
                                                                                                                                                                                                                                                                                                                                                                    age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 9
                                                                                                                                                                                                                                                                                                                                                                    Description
                                                                                                                                                                                                                                                                                                                                                                    Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                    INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                    Source
                                                                                                                                                                                                                                                                                                                                                                    GEO
                                                                                                                                                                                                                                                                                                                                                                    Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                    sample_accession: GSM1899848
                                                                                                                                                                                                                                                                                                                                                                    sample_title: Paired liver POST treatment pair and rep 9
                                                                                                                                                                                                                                                                                                                                                                    source_name: paired liver Post treatment pair and rep 9
                                                                                                                                                                                                                                                                                                                                                                    characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 9

                                                                                                                                                                                                                                                                                                                                                                    GSM1899849

                                                                                                                                                                                                                                                                                                                                                                    Uncertain

                                                                                                                                                                                                                                                                                                                                                                    Paired liver POST treatment pair and rep 10

                                                                                                                                                                                                                                                                                                                                                                    Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                    Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                    • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                      • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                      • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                        • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                        • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                          • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                            • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                            • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                              • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                              Source metadata
                                                                                                                                                                                                                                                                                                                                                                              Source name
                                                                                                                                                                                                                                                                                                                                                                              paired liver Post treatment pair and rep 10
                                                                                                                                                                                                                                                                                                                                                                              Characteristics
                                                                                                                                                                                                                                                                                                                                                                              age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 10
                                                                                                                                                                                                                                                                                                                                                                              Description
                                                                                                                                                                                                                                                                                                                                                                              Not reported
                                                                                                                                                                                                                                                                                                                                                                              Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                              Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                              INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                              Source
                                                                                                                                                                                                                                                                                                                                                                              GEO
                                                                                                                                                                                                                                                                                                                                                                              Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                              sample_accession: GSM1899849
                                                                                                                                                                                                                                                                                                                                                                              sample_title: Paired liver POST treatment pair and rep 10
                                                                                                                                                                                                                                                                                                                                                                              source_name: paired liver Post treatment pair and rep 10
                                                                                                                                                                                                                                                                                                                                                                              characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 10

                                                                                                                                                                                                                                                                                                                                                                              GSM1899850

                                                                                                                                                                                                                                                                                                                                                                              Uncertain

                                                                                                                                                                                                                                                                                                                                                                              Paired liver POST treatment pair and rep 11

                                                                                                                                                                                                                                                                                                                                                                              Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                              Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                              • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                  • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                  • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                    • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                    • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                      • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                      • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                        • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                        Source metadata
                                                                                                                                                                                                                                                                                                                                                                                        Source name
                                                                                                                                                                                                                                                                                                                                                                                        paired liver Post treatment pair and rep 11
                                                                                                                                                                                                                                                                                                                                                                                        Characteristics
                                                                                                                                                                                                                                                                                                                                                                                        age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 11
                                                                                                                                                                                                                                                                                                                                                                                        Description
                                                                                                                                                                                                                                                                                                                                                                                        Not reported
                                                                                                                                                                                                                                                                                                                                                                                        Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                        Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                        INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                        Source
                                                                                                                                                                                                                                                                                                                                                                                        GEO
                                                                                                                                                                                                                                                                                                                                                                                        Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                        sample_accession: GSM1899850
                                                                                                                                                                                                                                                                                                                                                                                        sample_title: Paired liver POST treatment pair and rep 11
                                                                                                                                                                                                                                                                                                                                                                                        source_name: paired liver Post treatment pair and rep 11
                                                                                                                                                                                                                                                                                                                                                                                        characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 11

                                                                                                                                                                                                                                                                                                                                                                                        GSM1899851

                                                                                                                                                                                                                                                                                                                                                                                        Uncertain

                                                                                                                                                                                                                                                                                                                                                                                        Paired liver POST treatment pair and rep 12

                                                                                                                                                                                                                                                                                                                                                                                        Not included: the study role or selected requirements have incomplete or conflicting evidence. organism: Homo sapiens — Insufficient evidence. assay type: bulk RNA-seq — Insufficient evidence. specimen category: Tissue or biopsy — Insufficient evidence. Study role: Case marker detected.

                                                                                                                                                                                                                                                                                                                                                                                        Requirements and decision evidence
                                                                                                                                                                                                                                                                                                                                                                                        • organism: Homo sapiens — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                          • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                          • assay type: bulk RNA-seq — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                            • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                            • specimen category: Tissue or biopsy — Insufficient evidence
                                                                                                                                                                                                                                                                                                                                                                                              • The required value is not reported.
                                                                                                                                                                                                                                                                                                                                                                                              • excluded sample type excludes: cell line, organoid, xenograft — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                • specimen category excludes: Biofluid — Meets requirement
                                                                                                                                                                                                                                                                                                                                                                                                  • Supported by the indexed evidence.
                                                                                                                                                                                                                                                                                                                                                                                                  Source metadata
                                                                                                                                                                                                                                                                                                                                                                                                  Source name
                                                                                                                                                                                                                                                                                                                                                                                                  paired liver Post treatment pair and rep 12
                                                                                                                                                                                                                                                                                                                                                                                                  Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                  age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 12
                                                                                                                                                                                                                                                                                                                                                                                                  Description
                                                                                                                                                                                                                                                                                                                                                                                                  Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed organism evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Indexed assay evidence
                                                                                                                                                                                                                                                                                                                                                                                                  INFERRED · PARENT_INHERITED: Not reported
                                                                                                                                                                                                                                                                                                                                                                                                  Source
                                                                                                                                                                                                                                                                                                                                                                                                  GEO
                                                                                                                                                                                                                                                                                                                                                                                                  Original indexed metadata
                                                                                                                                                                                                                                                                                                                                                                                                  sample_accession: GSM1899851
                                                                                                                                                                                                                                                                                                                                                                                                  sample_title: Paired liver POST treatment pair and rep 12
                                                                                                                                                                                                                                                                                                                                                                                                  source_name: paired liver Post treatment pair and rep 12
                                                                                                                                                                                                                                                                                                                                                                                                  characteristics: age: adult; disease state: advanced liver fibrosis; tissue: liver; treatment: simtuzumab; time point: post-treatment; participant: 12

                                                                                                                                                                                                                                                                                                                                                                                                  Excluded samples (0)

                                                                                                                                                                                                                                                                                                                                                                                                  No excluded samples.